ID   TTC30_DROPS             Reviewed;         654 AA.
AC   Q29L58;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Tetratricopeptide repeat protein 30 homolog;
DE            Short=TPR repeat protein 30 homolog;
GN   ORFNames=GA18687;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin in sensory
CC       cilia. Plays a role in anterograde intraflagellar transport (IFT), the
CC       process by which cilia precursors are transported from the base of the
CC       cilium to the site of their incorporation at the tip. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
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DR   EMBL; CH379061; EAL32966.1; -; Genomic_DNA.
DR   RefSeq; XP_001355907.1; XM_001355871.2.
DR   RefSeq; XP_015036544.1; XM_015181058.1.
DR   AlphaFoldDB; Q29L58; -.
DR   SMR; Q29L58; -.
DR   STRING; 7237.FBpp0287699; -.
DR   EnsemblMetazoa; FBtr0289261; FBpp0287699; FBgn0078687.
DR   EnsemblMetazoa; FBtr0377042; FBpp0338148; FBgn0078687.
DR   KEGG; dpo:Dpse_GA18687; -.
DR   eggNOG; KOG4340; Eukaryota.
DR   HOGENOM; CLU_023760_0_0_1; -.
DR   InParanoid; Q29L58; -.
DR   OMA; MRNHPEL; -.
DR   PhylomeDB; Q29L58; -.
DR   Proteomes; UP000001819; Genome assembly.
DR   Bgee; FBgn0078687; Expressed in female reproductive system and 1 other tissue.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR013105; TPR_2.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931; PTHR20931; 1.
DR   Pfam; PF07719; TPR_2; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Reference proteome;
KW   Repeat; TPR repeat.
FT   CHAIN           1..654
FT                   /note="Tetratricopeptide repeat protein 30 homolog"
FT                   /id="PRO_0000333214"
FT   REPEAT          10..43
FT                   /note="TPR 1"
FT   REPEAT          44..76
FT                   /note="TPR 2"
FT   REPEAT          143..176
FT                   /note="TPR 3"
FT   REPEAT          178..210
FT                   /note="TPR 4"
FT   REPEAT          384..417
FT                   /note="TPR 5"
FT   REPEAT          449..483
FT                   /note="TPR 6"
FT   REPEAT          533..566
FT                   /note="TPR 7"
SQ   SEQUENCE   654 AA;  72874 MW;  D5A4B27B7D87A147 CRC64;
     MLHQGIILRE GHVTRTIYNL IKDKRYEDVI ECITNIGEAA NTRAGLSTLG HCYYHAQKYE
     EAATCYEQLC QLAPKEAKYR FYYAQSLYQA GIFAEALRVL KQISDQEEEL REHCLQLQSA
     ILYSSEDYAG AQSLLNQRAG GTADTLNDEG CLLYQADQHE SAVQRFQAAL QVGGFNPLVA
     YNVALAHFQR KQRAQALDYT SEIVERGVRN HPELGIGAQV DTDGSARSVG NPITMAMSGI
     TQALNLKAAL EYQDGNEEGA REALLDLPPR AESELDPVTL HNMALTDVQG PVAGLRKLAF
     LLQLGAPSCP KETFANILLI CCRHELYETA ADILAEHTDL TYKYLSQYLY ELLDALITAQ
     TSVELAEKKL GTLASSLAGK LRSLAAKVQE VRATNEQHAL RDALKDYEQA LELYLPVVMA
     RAWISWRDDD FVGAEREFHS SAEFCSENAV WRLNAGHVLF MQGDKYNEAA AFYEPIVRQH
     SDDIMSVSAA VLANLCVSYI MTFQNEEAEE LMRKVEKAEE LKGNLGKQYH HLCIVNLVVG
     TLYCAKSNYE FGLTRIAHAL EGGAGGRLYA DTWLHVKRCI LGLLTGMAKQ NIILPYTAVQ
     EVLGFLRSCE AYGLFTPANI FTATEQVPEE PLTIGLEARK LRLLLLKLSE YENC