TTC31_HUMAN
ID TTC31_HUMAN Reviewed; 519 AA.
AC Q49AM3; Q4KN40; Q53FD4; Q9H9F7;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Tetratricopeptide repeat protein 31;
DE Short=TPR repeat protein 31;
GN Name=TTC31;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP VAL-28.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-369.
RC TISSUE=Testis;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q49AM3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q49AM3-2; Sequence=VSP_023990, VSP_023991;
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DR EMBL; AK022850; BAB14272.1; -; mRNA.
DR EMBL; AC005041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036017; AAH36017.1; -; mRNA.
DR EMBL; BC096709; AAH96709.1; -; mRNA.
DR EMBL; AK223355; BAD97075.1; -; mRNA.
DR CCDS; CCDS42701.1; -. [Q49AM3-1]
DR RefSeq; NP_071937.4; NM_022492.4. [Q49AM3-1]
DR AlphaFoldDB; Q49AM3; -.
DR SMR; Q49AM3; -.
DR BioGRID; 122175; 23.
DR IntAct; Q49AM3; 5.
DR STRING; 9606.ENSP00000233623; -.
DR iPTMnet; Q49AM3; -.
DR PhosphoSitePlus; Q49AM3; -.
DR BioMuta; TTC31; -.
DR DMDM; 215274203; -.
DR EPD; Q49AM3; -.
DR jPOST; Q49AM3; -.
DR MassIVE; Q49AM3; -.
DR MaxQB; Q49AM3; -.
DR PaxDb; Q49AM3; -.
DR PeptideAtlas; Q49AM3; -.
DR PRIDE; Q49AM3; -.
DR ProteomicsDB; 62056; -. [Q49AM3-1]
DR ProteomicsDB; 62057; -. [Q49AM3-2]
DR Antibodypedia; 31535; 26 antibodies from 13 providers.
DR DNASU; 64427; -.
DR Ensembl; ENST00000233623.11; ENSP00000233623.6; ENSG00000115282.21. [Q49AM3-1]
DR Ensembl; ENST00000442235.6; ENSP00000416823.3; ENSG00000115282.21. [Q49AM3-2]
DR GeneID; 64427; -.
DR KEGG; hsa:64427; -.
DR MANE-Select; ENST00000233623.11; ENSP00000233623.6; NM_022492.6; NP_071937.4.
DR UCSC; uc002slt.3; human. [Q49AM3-1]
DR CTD; 64427; -.
DR GeneCards; TTC31; -.
DR HGNC; HGNC:25759; TTC31.
DR HPA; ENSG00000115282; Low tissue specificity.
DR neXtProt; NX_Q49AM3; -.
DR OpenTargets; ENSG00000115282; -.
DR PharmGKB; PA145147843; -.
DR VEuPathDB; HostDB:ENSG00000115282; -.
DR eggNOG; KOG0548; Eukaryota.
DR GeneTree; ENSGT00940000161036; -.
DR HOGENOM; CLU_039740_1_0_1; -.
DR InParanoid; Q49AM3; -.
DR OMA; QKSFLYP; -.
DR OrthoDB; 673908at2759; -.
DR PhylomeDB; Q49AM3; -.
DR TreeFam; TF341776; -.
DR PathwayCommons; Q49AM3; -.
DR SignaLink; Q49AM3; -.
DR BioGRID-ORCS; 64427; 8 hits in 1072 CRISPR screens.
DR ChiTaRS; TTC31; human.
DR GenomeRNAi; 64427; -.
DR Pharos; Q49AM3; Tdark.
DR PRO; PR:Q49AM3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q49AM3; protein.
DR Bgee; ENSG00000115282; Expressed in sural nerve and 179 other tissues.
DR ExpressionAtlas; Q49AM3; baseline and differential.
DR Genevisible; Q49AM3; HS.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome;
KW Repeat; TPR repeat.
FT CHAIN 1..519
FT /note="Tetratricopeptide repeat protein 31"
FT /id="PRO_0000281149"
FT REPEAT 305..338
FT /note="TPR 1"
FT REPEAT 339..372
FT /note="TPR 2"
FT REPEAT 373..406
FT /note="TPR 3"
FT REGION 175..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 147..197
FT /evidence="ECO:0000255"
FT COMPBIAS 199..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 278
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 281..285
FT /note="REERP -> ATSPC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023990"
FT VAR_SEQ 286..519
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023991"
FT VARIANT 28
FT /note="A -> V (in dbSNP:rs6707475)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_047357"
FT VARIANT 205
FT /note="T -> P (in dbSNP:rs35852562)"
FT /id="VAR_047358"
FT CONFLICT 141
FT /note="L -> P (in Ref. 1; BAB14272)"
FT /evidence="ECO:0000305"
FT CONFLICT 216
FT /note="P -> T (in Ref. 3; AAH36017)"
FT /evidence="ECO:0000305"
FT CONFLICT 413
FT /note="R -> H (in Ref. 3; AAH36017)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 519 AA; 57105 MW; B618E043E0FBD78E CRC64;
MAPIPKTVGR IKLDCSLRPS CPLEVAAAPK LCKEFGPEDY GEEDIVDFLR RLVESDPQGL
HRIHVDGSSG RLQLWHHDYL LGHLDDEGKS TGQSDRGKGA EGLGTYCGLR KSFLYPPQES
EPCPQSPSAS ATFPSVSDSL LQVAMPQKLL VTEEEANRLA EELVAEEERM KQKAEKKRLK
KKRQKERKRQ ERLEQYCGEP KASTTSDGDE SPPSSPGNPV QGQCGEEEDS LDLSSTFVSL
ALRKVGDWPL SARREKGLNQ EPQGRGLALQ KMGQEEESPP REERPQQSPK VQASPGLLAA
ALQQSQELAK LGTSFAQNGF YHEAVVLFTQ ALKLNPQDHR LFGNRSFCHE RLGQPAWALA
DAQVALTLRP GWPRGLFRLG KALMGLQRFR EAAAVFQETL RGGSQPDAAR ELRSCLLHLT
LQGQRGGICA PPLSPGALQP LPHAELAPSG LPSLRCPRST ALRSPGLSPL LHYPSCHRSH
PNQPLSQTQS RRPHPLKPQD PSKGWDILGL GLQHLSQAR
