TTC33_HUMAN
ID TTC33_HUMAN Reviewed; 262 AA.
AC Q6PID6; B2R6G0; O95105;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Tetratricopeptide repeat protein 33;
DE Short=TPR repeat protein 33;
DE AltName: Full=Osmosis-responsive factor;
GN Name=TTC33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skeletal muscle;
RA Giot J.F.;
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197 AND THR-251, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q6PID6; P02649: APOE; NbExp=3; IntAct=EBI-2555404, EBI-1222467;
CC Q6PID6; Q96A83-2: COL26A1; NbExp=3; IntAct=EBI-2555404, EBI-21553822;
CC Q6PID6; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-2555404, EBI-12593112;
CC Q6PID6; O14645: DNALI1; NbExp=3; IntAct=EBI-2555404, EBI-395638;
CC Q6PID6; P26378-2: ELAVL4; NbExp=3; IntAct=EBI-2555404, EBI-21603100;
CC Q6PID6; O14901: KLF11; NbExp=3; IntAct=EBI-2555404, EBI-948266;
CC Q6PID6; Q8WV92: MITD1; NbExp=3; IntAct=EBI-2555404, EBI-2691489;
CC Q6PID6; Q92597: NDRG1; NbExp=3; IntAct=EBI-2555404, EBI-716486;
CC Q6PID6; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-2555404, EBI-2811583;
CC Q6PID6; P20618: PSMB1; NbExp=3; IntAct=EBI-2555404, EBI-372273;
CC Q6PID6; P56279: TCL1A; NbExp=7; IntAct=EBI-2555404, EBI-749995;
CC Q6PID6; P40222: TXLNA; NbExp=6; IntAct=EBI-2555404, EBI-359793;
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DR EMBL; AF023244; AAD09341.1; -; mRNA.
DR EMBL; AK312560; BAG35457.1; -; mRNA.
DR EMBL; CH471119; EAW55998.1; -; Genomic_DNA.
DR EMBL; BC015701; AAH15701.1; -; mRNA.
DR EMBL; BC036536; AAH36536.1; -; mRNA.
DR CCDS; CCDS3931.1; -.
DR RefSeq; NP_036514.1; NM_012382.2.
DR RefSeq; XP_011512305.1; XM_011514003.2.
DR AlphaFoldDB; Q6PID6; -.
DR SMR; Q6PID6; -.
DR BioGRID; 117092; 48.
DR IntAct; Q6PID6; 32.
DR MINT; Q6PID6; -.
DR STRING; 9606.ENSP00000338533; -.
DR GlyGen; Q6PID6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6PID6; -.
DR PhosphoSitePlus; Q6PID6; -.
DR BioMuta; TTC33; -.
DR DMDM; 147737109; -.
DR EPD; Q6PID6; -.
DR jPOST; Q6PID6; -.
DR MassIVE; Q6PID6; -.
DR MaxQB; Q6PID6; -.
DR PaxDb; Q6PID6; -.
DR PeptideAtlas; Q6PID6; -.
DR PRIDE; Q6PID6; -.
DR ProteomicsDB; 67149; -.
DR Antibodypedia; 23145; 186 antibodies from 23 providers.
DR DNASU; 23548; -.
DR Ensembl; ENST00000337702.5; ENSP00000338533.4; ENSG00000113638.14.
DR GeneID; 23548; -.
DR KEGG; hsa:23548; -.
DR MANE-Select; ENST00000337702.5; ENSP00000338533.4; NM_012382.3; NP_036514.1.
DR UCSC; uc003jma.4; human.
DR CTD; 23548; -.
DR DisGeNET; 23548; -.
DR GeneCards; TTC33; -.
DR HGNC; HGNC:29959; TTC33.
DR HPA; ENSG00000113638; Low tissue specificity.
DR neXtProt; NX_Q6PID6; -.
DR OpenTargets; ENSG00000113638; -.
DR PharmGKB; PA162407196; -.
DR VEuPathDB; HostDB:ENSG00000113638; -.
DR eggNOG; KOG0553; Eukaryota.
DR GeneTree; ENSGT00390000017462; -.
DR HOGENOM; CLU_1061581_0_0_1; -.
DR InParanoid; Q6PID6; -.
DR OMA; DDGNWLH; -.
DR OrthoDB; 1579428at2759; -.
DR PhylomeDB; Q6PID6; -.
DR TreeFam; TF332142; -.
DR PathwayCommons; Q6PID6; -.
DR SignaLink; Q6PID6; -.
DR BioGRID-ORCS; 23548; 10 hits in 1074 CRISPR screens.
DR ChiTaRS; TTC33; human.
DR GenomeRNAi; 23548; -.
DR Pharos; Q6PID6; Tdark.
DR PRO; PR:Q6PID6; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6PID6; protein.
DR Bgee; ENSG00000113638; Expressed in calcaneal tendon and 189 other tissues.
DR ExpressionAtlas; Q6PID6; baseline and differential.
DR Genevisible; Q6PID6; HS.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..262
FT /note="Tetratricopeptide repeat protein 33"
FT /id="PRO_0000287515"
FT REPEAT 59..92
FT /note="TPR 1"
FT REPEAT 93..126
FT /note="TPR 2"
FT REPEAT 127..160
FT /note="TPR 3"
FT MOD_RES 197
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 251
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 69
FT /note="L -> M (in dbSNP:rs837105)"
FT /id="VAR_032317"
FT CONFLICT 13
FT /note="K -> R (in Ref. 4; AAH36536)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 262 AA; 29411 MW; A5549AC3973FABC9 CRC64;
MASFGWKRKI GEKVSKVTSQ QFEAEAADEK DVVDNDEGNW LHAIKRRKEI LLEGCAEKSK
QLKDEGASLA ENKRYREAIQ KWDEALQLTP NDATLYEMKS QVLMSLHEMF PAVHAAEMAV
QQNPHSWESW QTLGRAQLGL GEIILAIRSF QVALHIYPMN PEIWKEDLSW ARTLQEQQKV
AQRIKKSEAP AEVTHFSPKS IPDYDFESDE IVAVCAAIAE KEKTVSANKT MVIVSASGAI
ETVTEKEDGA TPPDGSVFIK AR
