TTC33_MOUSE
ID TTC33_MOUSE Reviewed; 262 AA.
AC Q9D6K7; Q8VIG5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Tetratricopeptide repeat protein 33;
DE Short=TPR repeat protein 33;
GN Name=Ttc33;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, and Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D6K7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D6K7-2; Sequence=VSP_025532, VSP_025533;
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DR EMBL; AK013464; BAB28868.1; -; mRNA.
DR EMBL; AK050426; BAC34250.1; -; mRNA.
DR EMBL; AK075643; BAC35877.1; -; mRNA.
DR EMBL; BC017533; AAH17533.1; -; mRNA.
DR EMBL; BC061018; AAH61018.1; -; mRNA.
DR CCDS; CCDS27364.1; -. [Q9D6K7-1]
DR RefSeq; NP_080489.1; NM_026213.3. [Q9D6K7-1]
DR RefSeq; XP_006520055.1; XM_006519992.3.
DR RefSeq; XP_006520056.1; XM_006519993.2.
DR AlphaFoldDB; Q9D6K7; -.
DR SMR; Q9D6K7; -.
DR BioGRID; 212242; 1.
DR STRING; 10090.ENSMUSP00000022751; -.
DR iPTMnet; Q9D6K7; -.
DR PhosphoSitePlus; Q9D6K7; -.
DR EPD; Q9D6K7; -.
DR MaxQB; Q9D6K7; -.
DR PaxDb; Q9D6K7; -.
DR PeptideAtlas; Q9D6K7; -.
DR PRIDE; Q9D6K7; -.
DR ProteomicsDB; 298329; -. [Q9D6K7-1]
DR ProteomicsDB; 298330; -. [Q9D6K7-2]
DR Antibodypedia; 23145; 186 antibodies from 23 providers.
DR Ensembl; ENSMUST00000022751; ENSMUSP00000022751; ENSMUSG00000022151. [Q9D6K7-1]
DR Ensembl; ENSMUST00000081640; ENSMUSP00000080345; ENSMUSG00000022151. [Q9D6K7-2]
DR Ensembl; ENSMUST00000118193; ENSMUSP00000114033; ENSMUSG00000022151. [Q9D6K7-1]
DR GeneID; 67515; -.
DR KEGG; mmu:67515; -.
DR UCSC; uc007vcv.1; mouse. [Q9D6K7-1]
DR CTD; 23548; -.
DR MGI; MGI:1914765; Ttc33.
DR VEuPathDB; HostDB:ENSMUSG00000022151; -.
DR eggNOG; KOG0553; Eukaryota.
DR GeneTree; ENSGT00390000017462; -.
DR HOGENOM; CLU_1061581_0_0_1; -.
DR InParanoid; Q9D6K7; -.
DR OMA; DDGNWLH; -.
DR OrthoDB; 1579428at2759; -.
DR PhylomeDB; Q9D6K7; -.
DR TreeFam; TF332142; -.
DR BioGRID-ORCS; 67515; 6 hits in 74 CRISPR screens.
DR PRO; PR:Q9D6K7; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9D6K7; protein.
DR Bgee; ENSMUSG00000022151; Expressed in saccule of membranous labyrinth and 255 other tissues.
DR ExpressionAtlas; Q9D6K7; baseline and differential.
DR Genevisible; Q9D6K7; MM.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..262
FT /note="Tetratricopeptide repeat protein 33"
FT /id="PRO_0000287516"
FT REPEAT 59..92
FT /note="TPR 1"
FT REPEAT 93..126
FT /note="TPR 2"
FT REPEAT 127..160
FT /note="TPR 3"
FT REGION 17..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 197
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6PID6"
FT VAR_SEQ 75..105
FT /note="YKEAIQKWDEALQLTPGDATLYEMKSQVLLS -> SCCLFMKCFQQSMQQRW
FT LSSVTHTRGRRGKL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025532"
FT VAR_SEQ 106..262
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025533"
SQ SEQUENCE 262 AA; 29371 MW; C76BA8CF9B177423 CRC64;
MASFGWKRRI GEKVSKATSQ QFEAEAADEK DAAENEDGNW LQASKRRKET LQEGCKQRSQ
QLKDEGAQLA ENKRYKEAIQ KWDEALQLTP GDATLYEMKS QVLLSLHEMF PAVHAAEMAV
KRNPHSWEAW QTLGRAQLGL GEIVLAIRSF QIALHIYPMN PELWKEDLSW ARKLQEQQKV
AQRIENKEMP PEGPDLSPGS IPDYDFESDE IVAVCAAVAE KQKSVSANKT MVIVSASGTV
EIVNEKEEGS STPDGSVFIK AR
