TTC34_HUMAN
ID TTC34_HUMAN Reviewed; 566 AA.
AC A8MYJ7; A8MXL8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Tetratricopeptide repeat protein 34;
DE Short=TPR repeat protein 34;
GN Name=TTC34;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-190.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL592464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL831784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DN831537; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; DN831538; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; DY655627; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001229601.1; NM_001242672.1.
DR RefSeq; XP_016855479.1; XM_016999990.1.
DR AlphaFoldDB; A8MYJ7; -.
DR SMR; A8MYJ7; -.
DR BioGRID; 939557; 1.
DR IntAct; A8MYJ7; 1.
DR STRING; 9606.ENSP00000383873; -.
DR PhosphoSitePlus; A8MYJ7; -.
DR BioMuta; TTC34; -.
DR MassIVE; A8MYJ7; -.
DR PaxDb; A8MYJ7; -.
DR PeptideAtlas; A8MYJ7; -.
DR PRIDE; A8MYJ7; -.
DR ProteomicsDB; 2407; -.
DR Antibodypedia; 67410; 65 antibodies from 13 providers.
DR DNASU; 100287898; -.
DR Ensembl; ENST00000611612.2; ENSP00000483029.1; ENSG00000275571.2.
DR Ensembl; ENST00000637179.1; ENSP00000490537.1; ENSG00000215912.12.
DR GeneID; 100287898; -.
DR KEGG; hsa:100287898; -.
DR UCSC; uc021oey.2; human.
DR CTD; 100287898; -.
DR DisGeNET; 100287898; -.
DR GeneCards; TTC34; -.
DR HGNC; HGNC:34297; TTC34.
DR HPA; ENSG00000215912; Tissue enhanced (testis).
DR neXtProt; NX_A8MYJ7; -.
DR OpenTargets; ENSG00000215912; -.
DR PharmGKB; PA162407211; -.
DR VEuPathDB; HostDB:ENSG00000215912; -.
DR eggNOG; ENOG502QRDY; Eukaryota.
DR GeneTree; ENSGT00390000003047; -.
DR HOGENOM; CLU_030342_0_0_1; -.
DR InParanoid; A8MYJ7; -.
DR OMA; EAWCRGD; -.
DR OrthoDB; 1024217at2759; -.
DR PhylomeDB; A8MYJ7; -.
DR TreeFam; TF332803; -.
DR PathwayCommons; A8MYJ7; -.
DR SignaLink; A8MYJ7; -.
DR BioGRID-ORCS; 100287898; 7 hits in 1062 CRISPR screens.
DR ChiTaRS; TTC34; human.
DR GenomeRNAi; 100287898; -.
DR Pharos; A8MYJ7; Tdark.
DR PRO; PR:A8MYJ7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A8MYJ7; protein.
DR Bgee; ENSG00000215912; Expressed in right uterine tube and 82 other tissues.
DR ExpressionAtlas; A8MYJ7; baseline and differential.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR042161; TTC34.
DR PANTHER; PTHR44874; PTHR44874; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 4.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..566
FT /note="Tetratricopeptide repeat protein 34"
FT /id="PRO_0000341278"
FT REPEAT 50..83
FT /note="TPR 1"
FT REPEAT 178..211
FT /note="TPR 2"
FT REPEAT 212..245
FT /note="TPR 3"
FT REPEAT 306..339
FT /note="TPR 4"
FT REPEAT 341..373
FT /note="TPR 5"
FT REPEAT 424..457
FT /note="TPR 6"
FT REPEAT 464..497
FT /note="TPR 7"
FT REPEAT 512..545
FT /note="TPR 8"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 60903 MW; 6668E05E87DC3E73 CRC64;
MLQRSPRAGP SRAQGRREAA ETGGPTTQEG VACGVHQLAT LLMELDSEDE ASRLLAADAL
YRLGRLEETH KALLVALSRR PQAAPVLARL ALLQLRRGFF YDANQLVKKL VQSGDTACLQ
PTLDVFCHED RQLLQGHCHA RALAILRARP GGADGRVHTK EAIAYLSLAI FAAGSQASES
LLARARCYGF LGQKKTAMFD FNTVLRAEPG NVQALCGRAL VHLALDQLQE AVDDIVSALK
LGPGTVVPEL RSLKPEAQAL ITQGLYSHCR ALLSQLPDTG APLEDKDTQG LLAVGEALIK
IDSGQPHWHL LLADILMAQG SYEEAGTHLE KALHRAPTSE AARARLGLLQ LKKGDVPGAA
RDLQSLAEVD APDLSCLLHL LEASERQSLA QAAAQEAGTL LDAGQPRQAL GYCSLSVLAS
GSSACHLRLR ATCLAELQEF GRALRDLDHV LQEALGDGDL PRRAEDFCRQ GRLLLSLGDE
AAAAGAFAQA LKLAPSLAQN SLCRQPGRAP TARMFLLRGQ CCLEEQRHAE AWTAVESGLL
VDPDHRGLKR LKARIRREAS SGCWLQ
