TTC34_MOUSE
ID TTC34_MOUSE Reviewed; 554 AA.
AC Q8C0Q3; B1AS13; Q6NV67;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Tetratricopeptide repeat protein 34;
DE Short=TPR repeat protein 34;
GN Name=Ttc34;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CD-1; TISSUE=Neural stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK030055; BAC26761.1; -; mRNA.
DR EMBL; AL607032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC068299; AAH68299.1; -; mRNA.
DR RefSeq; NP_766466.3; NM_172878.3.
DR AlphaFoldDB; Q8C0Q3; -.
DR SMR; Q8C0Q3; -.
DR STRING; 10090.ENSMUSP00000051782; -.
DR iPTMnet; Q8C0Q3; -.
DR PhosphoSitePlus; Q8C0Q3; -.
DR PaxDb; Q8C0Q3; -.
DR PRIDE; Q8C0Q3; -.
DR ProteomicsDB; 297675; -.
DR Antibodypedia; 67410; 65 antibodies from 13 providers.
DR Ensembl; ENSMUST00000050220; ENSMUSP00000051782; ENSMUSG00000046637.
DR GeneID; 242800; -.
DR KEGG; mmu:242800; -.
DR UCSC; uc012dql.1; mouse.
DR CTD; 100287898; -.
DR MGI; MGI:2445205; Ttc34.
DR VEuPathDB; HostDB:ENSMUSG00000046637; -.
DR eggNOG; ENOG502QRDY; Eukaryota.
DR GeneTree; ENSGT00390000003047; -.
DR HOGENOM; CLU_030342_0_0_1; -.
DR InParanoid; Q8C0Q3; -.
DR OMA; AQHHIFY; -.
DR PhylomeDB; Q8C0Q3; -.
DR TreeFam; TF332803; -.
DR BioGRID-ORCS; 242800; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q8C0Q3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8C0Q3; protein.
DR Bgee; ENSMUSG00000046637; Expressed in animal zygote and 39 other tissues.
DR ExpressionAtlas; Q8C0Q3; baseline and differential.
DR Genevisible; Q8C0Q3; MM.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR042161; TTC34.
DR PANTHER; PTHR44874; PTHR44874; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..554
FT /note="Tetratricopeptide repeat protein 34"
FT /id="PRO_0000341279"
FT REPEAT 38..71
FT /note="TPR 1"
FT REPEAT 166..199
FT /note="TPR 2"
FT REPEAT 200..233
FT /note="TPR 3"
FT REPEAT 294..327
FT /note="TPR 4"
FT REPEAT 328..361
FT /note="TPR 5"
FT REPEAT 411..445
FT /note="TPR 6"
FT REPEAT 452..485
FT /note="TPR 7"
FT REPEAT 500..533
FT /note="TPR 8"
FT CONFLICT 235
FT /note="I -> T (in Ref. 3; AAH68299)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="M -> T (in Ref. 3; AAH68299)"
FT /evidence="ECO:0000305"
FT CONFLICT 348
FT /note="V -> A (in Ref. 3; AAH68299)"
FT /evidence="ECO:0000305"
FT CONFLICT 355
FT /note="A -> V (in Ref. 1; BAC26761)"
FT /evidence="ECO:0000305"
FT CONFLICT 367
FT /note="C -> R (in Ref. 3; AAH68299)"
FT /evidence="ECO:0000305"
FT CONFLICT 426
FT /note="Q -> R (in Ref. 3; AAH68299)"
FT /evidence="ECO:0000305"
FT CONFLICT 451
FT /note="Q -> R (in Ref. 3; AAH68299)"
FT /evidence="ECO:0000305"
FT CONFLICT 514
FT /note="E -> Q (in Ref. 3; AAH68299)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 554 AA; 60220 MW; 1896E3D8A60C6309 CRC64;
MLLRSPSYAG KAAQAQEGDA YGVYQLATLL IGMDAEDETS CLLAADALYR LGRLDDAHKS
LLVALSQRPQ AAPVLVRLAL LQLRRGFCYD ANQLVKKVAQ SGDTACLQHM LDIFHHEDLQ
LLQDHCHTRA LSILRARPGG SDSEAHTREA IAYLSLAIFA AGSGGSESLL VRARCYGLLG
QKKTAMFDFN AILREEPGNV KALCGRALVH LALDQLQEAV DDMVSALKLD PGTVIPEILS
LKTEVQLPLT QGLYTRCRVL LNQCLHTGVP LREEDTQGLL AMGKALIRIN ATQPSWRLLL
TDILTGLGKY QEAGTHLQEA LHLTPSSEAA QARQGLLQLK KGDVSAAVHG LQCLAERDTQ
DLGFLLCLLD SPERQSLVQT AAKEASNILD LGNPGQALSY CSLAILAGGN NPYHLRLRVA
CLTQLQEYDR ALRDLDRVLQ HPAEDSDLPR QSEDFCTRGR LLLSLGDKDG AAGAFTQALA
LAPAQAQNSL LEQPGQAMTA SVFLIHGQRC LEEEHFEEAW TAVQNGLLVD PSHSGLKKLK
LRTRKVATSG CRLH
