TTC36_HUMAN
ID TTC36_HUMAN Reviewed; 189 AA.
AC A6NLP5; B7ZW72; B9EJD8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Tetratricopeptide repeat protein 36;
DE Short=TPR repeat protein 36;
DE AltName: Full=HSP70-binding protein 21;
GN Name=TTC36; Synonyms=HBP21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Liu Q.H., Gao J.Y., Li J.M.;
RT "Cloning of HSP70 binding protein 21 in human PVR and breast cancer.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NLP5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NLP5-2; Sequence=VSP_055760;
CC -!- SIMILARITY: Belongs to the TTC36 family. {ECO:0000305}.
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DR EMBL; EU489483; ACA62794.1; -; mRNA.
DR EMBL; AP000941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW67387.1; -; Genomic_DNA.
DR EMBL; BC146916; AAI46917.1; -; mRNA.
DR EMBL; BC146921; AAI46922.1; -; mRNA.
DR EMBL; BC171906; AAI71906.1; -; mRNA.
DR EMBL; BC171913; AAI71913.1; -; mRNA.
DR CCDS; CCDS31687.1; -. [A6NLP5-1]
DR RefSeq; NP_001073910.1; NM_001080441.2. [A6NLP5-1]
DR RefSeq; NP_001333025.1; NM_001346096.1. [A6NLP5-2]
DR RefSeq; NP_001333026.1; NM_001346097.1. [A6NLP5-2]
DR RefSeq; NP_001333027.1; NM_001346098.1.
DR AlphaFoldDB; A6NLP5; -.
DR SMR; A6NLP5; -.
DR BioGRID; 126825; 2.
DR STRING; 9606.ENSP00000307640; -.
DR PhosphoSitePlus; A6NLP5; -.
DR BioMuta; TTC36; -.
DR MassIVE; A6NLP5; -.
DR PaxDb; A6NLP5; -.
DR PeptideAtlas; A6NLP5; -.
DR PRIDE; A6NLP5; -.
DR ProteomicsDB; 1487; -. [A6NLP5-1]
DR ProteomicsDB; 7272; -.
DR Antibodypedia; 52638; 8 antibodies from 7 providers.
DR DNASU; 143941; -.
DR Ensembl; ENST00000302783.10; ENSP00000307640.4; ENSG00000172425.12. [A6NLP5-1]
DR GeneID; 143941; -.
DR KEGG; hsa:143941; -.
DR MANE-Select; ENST00000302783.10; ENSP00000307640.4; NM_001080441.4; NP_001073910.1.
DR UCSC; uc001ptg.2; human. [A6NLP5-1]
DR CTD; 143941; -.
DR DisGeNET; 143941; -.
DR GeneCards; TTC36; -.
DR HGNC; HGNC:33708; TTC36.
DR HPA; ENSG00000172425; Tissue enriched (liver).
DR neXtProt; NX_A6NLP5; -.
DR OpenTargets; ENSG00000172425; -.
DR PharmGKB; PA162407225; -.
DR VEuPathDB; HostDB:ENSG00000172425; -.
DR eggNOG; KOG4555; Eukaryota.
DR GeneTree; ENSGT00390000007968; -.
DR HOGENOM; CLU_1464567_0_0_1; -.
DR InParanoid; A6NLP5; -.
DR OMA; PYSALCN; -.
DR OrthoDB; 1597848at2759; -.
DR PhylomeDB; A6NLP5; -.
DR TreeFam; TF105820; -.
DR PathwayCommons; A6NLP5; -.
DR BioGRID-ORCS; 143941; 13 hits in 1067 CRISPR screens.
DR GenomeRNAi; 143941; -.
DR Pharos; A6NLP5; Tdark.
DR PRO; PR:A6NLP5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NLP5; protein.
DR Bgee; ENSG00000172425; Expressed in right lobe of liver and 94 other tissues.
DR ExpressionAtlas; A6NLP5; baseline and differential.
DR Genevisible; A6NLP5; HS.
DR GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
DR GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
DR GO; GO:1902915; P:negative regulation of protein polyubiquitination; IEA:Ensembl.
DR GO; GO:0006570; P:tyrosine metabolic process; IEA:Ensembl.
DR GO; GO:0008542; P:visual learning; IEA:Ensembl.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR038906; TTC36.
DR PANTHER; PTHR21405; PTHR21405; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..189
FT /note="Tetratricopeptide repeat protein 36"
FT /id="PRO_0000332179"
FT REPEAT 51..84
FT /note="TPR 1"
FT REPEAT 86..118
FT /note="TPR 2"
FT REPEAT 123..156
FT /note="TPR 3"
FT VAR_SEQ 1..59
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055760"
FT VARIANT 78
FT /note="I -> M (in dbSNP:rs7111428)"
FT /id="VAR_042972"
SQ SEQUENCE 189 AA; 20896 MW; 2CB6547BADC98404 CRC64;
MGTPNDQAVL QAIFNPDTPF GDIVGLDLGE EAEKEEREED EVFPQAQLEQ SKALELQGVM
AAEAGDLSTA LERFGQAICL LPERASAYNN RAQARRLQGD VAGALEDLER AVELSGGRGR
AARQSFVQRG LLARLQGRDD DARRDFERAA RLGSPFARRQ LVLLNPYAAL CNRMLADMMG
QLRRPRDSR
