ID   TTC36_MOUSE             Reviewed;         186 AA.
AC   Q8VBW8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Tetratricopeptide repeat protein 36;
DE            Short=TPR repeat protein 36;
GN   Name=Ttc36;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Gall bladder, and Liver;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Kidney, and Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, and Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the TTC36 family. {ECO:0000305}.
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DR   EMBL; AK149384; BAE28845.1; -; mRNA.
DR   EMBL; AK165811; BAE38390.1; -; mRNA.
DR   EMBL; BC021608; AAH21608.1; -; mRNA.
DR   EMBL; BC021613; AAH21613.1; -; mRNA.
DR   EMBL; BC024432; AAH24432.1; -; mRNA.
DR   EMBL; BC026825; AAH26825.1; -; mRNA.
DR   CCDS; CCDS23121.1; -.
DR   RefSeq; NP_620401.1; NM_138951.1.
DR   AlphaFoldDB; Q8VBW8; -.
DR   SMR; Q8VBW8; -.
DR   BioGRID; 228694; 1.
DR   STRING; 10090.ENSMUSP00000042183; -.
DR   iPTMnet; Q8VBW8; -.
DR   PhosphoSitePlus; Q8VBW8; -.
DR   SwissPalm; Q8VBW8; -.
DR   jPOST; Q8VBW8; -.
DR   MaxQB; Q8VBW8; -.
DR   PaxDb; Q8VBW8; -.
DR   PeptideAtlas; Q8VBW8; -.
DR   PRIDE; Q8VBW8; -.
DR   ProteomicsDB; 298007; -.
DR   Antibodypedia; 52638; 8 antibodies from 7 providers.
DR   DNASU; 192653; -.
DR   Ensembl; ENSMUST00000044694; ENSMUSP00000042183; ENSMUSG00000039438.
DR   GeneID; 192653; -.
DR   KEGG; mmu:192653; -.
DR   UCSC; uc009peo.1; mouse.
DR   CTD; 143941; -.
DR   MGI; MGI:2384760; Ttc36.
DR   VEuPathDB; HostDB:ENSMUSG00000039438; -.
DR   eggNOG; KOG4555; Eukaryota.
DR   GeneTree; ENSGT00390000007968; -.
DR   HOGENOM; CLU_1464567_0_0_1; -.
DR   InParanoid; Q8VBW8; -.
DR   OMA; PYSALCN; -.
DR   OrthoDB; 1597848at2759; -.
DR   PhylomeDB; Q8VBW8; -.
DR   TreeFam; TF105820; -.
DR   BioGRID-ORCS; 192653; 6 hits in 74 CRISPR screens.
DR   PRO; PR:Q8VBW8; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q8VBW8; protein.
DR   Bgee; ENSMUSG00000039438; Expressed in proximal tubule and 65 other tissues.
DR   Genevisible; Q8VBW8; MM.
DR   GO; GO:0021954; P:central nervous system neuron development; IMP:MGI.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0007613; P:memory; IMP:MGI.
DR   GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IMP:MGI.
DR   GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.
DR   GO; GO:0032091; P:negative regulation of protein binding; IDA:MGI.
DR   GO; GO:1902915; P:negative regulation of protein polyubiquitination; IMP:MGI.
DR   GO; GO:0006570; P:tyrosine metabolic process; IMP:MGI.
DR   GO; GO:0008542; P:visual learning; IMP:MGI.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR038906; TTC36.
DR   PANTHER; PTHR21405; PTHR21405; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..186
FT                   /note="Tetratricopeptide repeat protein 36"
FT                   /id="PRO_0000332180"
FT   REPEAT          48..81
FT                   /note="TPR 1"
FT   REPEAT          83..115
FT                   /note="TPR 2"
FT   REPEAT          120..153
FT                   /note="TPR 3"
SQ   SEQUENCE   186 AA;  20132 MW;  59F3E986FCE2CADC CRC64;
     MGTPNDQAVL QAIFNPDTPF GDVVGLDLEE AEEGDEDGVF PQAQLEHSKA LELQGVRAAE
     AGDLHTALEK FGQAISLLPD RASAYNNRAQ ARRLQGDVAG ALEDLERAVT LSGGRGRAAR
     QSFVQSGLLA RFQGRDDDAR RDFEKAARLG SPFARRQLVL LNPYAALCNR MLADMMGQLR
     APSNGR