C4BPA_BOVIN
ID C4BPA_BOVIN Reviewed; 610 AA.
AC Q28065; Q2KJ87;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=C4b-binding protein alpha chain;
DE Short=C4bp;
DE Flags: Precursor;
GN Name=C4BPA;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=7930621;
RA Hillarp A., Thern A., Dahlbaech B.;
RT "Bovine C4b binding protein. Molecular cloning of the alpha- and beta-
RT chains provides structural background for lack of complex formation with
RT protein S.";
RL J. Immunol. 153:4190-4199(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Controls the classical pathway of complement activation. It
CC binds as a cofactor to C3b/C4b inactivator (C3bINA), which then
CC hydrolyzes the complement fragment C4b. It also accelerates the
CC degradation of the C4bC2a complex (C3 convertase) by dissociating the
CC complement fragment C2a. Alpha chain binds C4b. It interacts also with
CC serum amyloid P component.
CC -!- SUBUNIT: Disulfide-linked complex of alpha and beta chains.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
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DR EMBL; Z31693; CAA83498.1; -; mRNA.
DR EMBL; BC105469; AAI05470.1; -; mRNA.
DR PIR; I46001; I46001.
DR RefSeq; NP_776677.1; NM_174252.3.
DR RefSeq; XP_005216703.1; XM_005216646.3.
DR RefSeq; XP_005216704.1; XM_005216647.3.
DR RefSeq; XP_010811307.1; XM_010813005.2.
DR RefSeq; XP_010811308.1; XM_010813006.2.
DR RefSeq; XP_010811309.1; XM_010813007.2.
DR RefSeq; XP_010811310.1; XM_010813008.2.
DR RefSeq; XP_010811311.1; XM_010813009.2.
DR RefSeq; XP_010811312.1; XM_010813010.2.
DR RefSeq; XP_010811313.1; XM_010813011.2.
DR RefSeq; XP_010811314.1; XM_010813012.2.
DR AlphaFoldDB; Q28065; -.
DR SMR; Q28065; -.
DR STRING; 9913.ENSBTAP00000047025; -.
DR PaxDb; Q28065; -.
DR PRIDE; Q28065; -.
DR Ensembl; ENSBTAT00000013024; ENSBTAP00000013024; ENSBTAG00000009876.
DR Ensembl; ENSBTAT00000050299; ENSBTAP00000047025; ENSBTAG00000009876.
DR Ensembl; ENSBTAT00000070833; ENSBTAP00000073110; ENSBTAG00000009876.
DR GeneID; 281651; -.
DR KEGG; bta:281651; -.
DR CTD; 722; -.
DR VEuPathDB; HostDB:ENSBTAG00000009876; -.
DR VGNC; VGNC:103055; C4BPA.
DR eggNOG; ENOG502SHRK; Eukaryota.
DR GeneTree; ENSGT00940000154640; -.
DR HOGENOM; CLU_020107_5_2_1; -.
DR InParanoid; Q28065; -.
DR OMA; AAFWIFK; -.
DR OrthoDB; 1058295at2759; -.
DR TreeFam; TF334137; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000009876; Expressed in liver and 68 other tissues.
DR ExpressionAtlas; Q28065; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0045959; P:negative regulation of complement activation, classical pathway; IBA:GO_Central.
DR CDD; cd00033; CCP; 7.
DR InterPro; IPR040514; C4bp_oligo.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF18453; C4bp_oligo; 1.
DR Pfam; PF00084; Sushi; 8.
DR SMART; SM00032; CCP; 8.
DR SUPFAM; SSF57535; SSF57535; 8.
DR PROSITE; PS50923; SUSHI; 8.
PE 2: Evidence at transcript level;
KW Complement pathway; Disulfide bond; Glycoprotein; Immunity;
KW Innate immunity; Reference proteome; Repeat; Secreted; Signal; Sushi.
FT SIGNAL 1..48
FT /evidence="ECO:0000250"
FT CHAIN 49..610
FT /note="C4b-binding protein alpha chain"
FT /id="PRO_0000005887"
FT DOMAIN 49..109
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 110..171
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 172..236
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 237..296
FT /note="Sushi 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 297..364
FT /note="Sushi 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 365..427
FT /note="Sushi 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 428..485
FT /note="Sushi 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 486..543
FT /note="Sushi 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 221
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 525
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 602
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 50..95
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 80..107
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 112..153
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 139..169
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 174..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 203..234
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 239..281
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 267..294
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 299..350
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 334..362
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 367..412
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 402..425
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 429..471
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 457..483
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 487..528
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 514..541
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 549
FT /note="Interchain (with beta chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 561
FT /note="Interchain (with beta chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 610 AA; 68886 MW; D806B270E8A06B58 CRC64;
MKHQRVPVMI LHSKGTMASW PFSRLWSISD PILFQVTLVA TLLATVLGSC GIPPYLDFAF
PINELNETRF ETGTTLRYTC RPGYRISSRK NFLICDGTDN WKYKEFCVKK RCENPGELLN
GQVIVKTDYS FGSEIEFSCS EGYVLIGSAN SYCQLQDKGV VWSDPLPQCI IAKCEPPPTI
SNGRHNGGDE DFYTYGSSVT YSCDRDFSML GKASISCRVE NKTIGVWSPS PPSCKKVICV
QPVVKDGKIT SGFGPIYTYQ QSIVYACNKG FRLEGDSLIH CEADNSWNPP PPTCELNGCL
GLPHIPHALW ERYDHQTQTE QQVYDIGFVL SYKCHFGYKP ETDGPTTVTC QSNLEWSPYI
ECKEVCCPEP NLNNYGSITL HRRPSTSTHC TYISGDKISY ECHSKYMFDA LCTKHGTWSP
RTPECRPDCK SPPVIAHGQH KVVSKFFTFD HQAVYECDKG YILVGAKELS CTSSGWSPAV
PQCKALCLKP EIEYGRLSVE KVRYVEPEII TIQCESGYSV VGSENITCSE DRTWYPEVPK
CEWEYPEGCE QVVTGRKLLQ CLSRPEEVKL ALEVYKLSLE IEILQTNKLK KEAFLLRERE
KNVTCDFNPE
