TTC38_HUMAN
ID TTC38_HUMAN Reviewed; 469 AA.
AC Q5R3I4; Q8WV27; Q9NWP8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Tetratricopeptide repeat protein 38;
DE Short=TPR repeat protein 38;
GN Name=TTC38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-243.
RC TISSUE=Ileal mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-243.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-243.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE
RP ANALYSIS] AT SER-5, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE
RP ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SIMILARITY: Belongs to the TTC38 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91331.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK000706; BAA91331.1; ALT_FRAME; mRNA.
DR EMBL; Z93024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471138; EAW73414.1; -; Genomic_DNA.
DR EMBL; BC018918; AAH18918.2; -; mRNA.
DR CCDS; CCDS43030.1; -.
DR RefSeq; NP_060401.2; NM_017931.2.
DR AlphaFoldDB; Q5R3I4; -.
DR SMR; Q5R3I4; -.
DR BioGRID; 120351; 16.
DR IntAct; Q5R3I4; 6.
DR MINT; Q5R3I4; -.
DR STRING; 9606.ENSP00000370419; -.
DR GlyGen; Q5R3I4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5R3I4; -.
DR PhosphoSitePlus; Q5R3I4; -.
DR BioMuta; TTC38; -.
DR DMDM; 74755898; -.
DR EPD; Q5R3I4; -.
DR jPOST; Q5R3I4; -.
DR MassIVE; Q5R3I4; -.
DR MaxQB; Q5R3I4; -.
DR PaxDb; Q5R3I4; -.
DR PeptideAtlas; Q5R3I4; -.
DR PRIDE; Q5R3I4; -.
DR ProteomicsDB; 63726; -.
DR Antibodypedia; 28031; 47 antibodies from 14 providers.
DR DNASU; 55020; -.
DR Ensembl; ENST00000381031.8; ENSP00000370419.3; ENSG00000075234.17.
DR GeneID; 55020; -.
DR KEGG; hsa:55020; -.
DR MANE-Select; ENST00000381031.8; ENSP00000370419.3; NM_017931.4; NP_060401.3.
DR UCSC; uc003bhi.3; human.
DR CTD; 55020; -.
DR DisGeNET; 55020; -.
DR GeneCards; TTC38; -.
DR HGNC; HGNC:26082; TTC38.
DR HPA; ENSG00000075234; Tissue enhanced (liver).
DR neXtProt; NX_Q5R3I4; -.
DR OpenTargets; ENSG00000075234; -.
DR PharmGKB; PA162407227; -.
DR VEuPathDB; HostDB:ENSG00000075234; -.
DR eggNOG; KOG2610; Eukaryota.
DR GeneTree; ENSGT00390000002669; -.
DR HOGENOM; CLU_029972_1_2_1; -.
DR InParanoid; Q5R3I4; -.
DR OMA; DAWGLHA; -.
DR OrthoDB; 824041at2759; -.
DR PhylomeDB; Q5R3I4; -.
DR TreeFam; TF313343; -.
DR PathwayCommons; Q5R3I4; -.
DR SignaLink; Q5R3I4; -.
DR BioGRID-ORCS; 55020; 7 hits in 1076 CRISPR screens.
DR ChiTaRS; TTC38; human.
DR GenomeRNAi; 55020; -.
DR Pharos; Q5R3I4; Tdark.
DR PRO; PR:Q5R3I4; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q5R3I4; protein.
DR Bgee; ENSG00000075234; Expressed in right lobe of liver and 125 other tissues.
DR ExpressionAtlas; Q5R3I4; baseline and differential.
DR Genevisible; Q5R3I4; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR CDD; cd05804; StaR_like; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR033891; TTC38.
DR PANTHER; PTHR16263; PTHR16263; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:20068231"
FT CHAIN 2..469
FT /note="Tetratricopeptide repeat protein 38"
FT /id="PRO_0000321530"
FT REPEAT 108..141
FT /note="TPR 1"
FT REPEAT 180..213
FT /note="TPR 2"
FT REPEAT 252..285
FT /note="TPR 3"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 5
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT VARIANT 243
FT /note="F -> L (in dbSNP:rs130642)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_039344"
SQ SEQUENCE 469 AA; 52787 MW; 2E35F3C095FB9B31 CRC64;
MAAASPLRDC QAWKDARLPL STTSNEACKL FDATLTQYVK WTNDKSLGGI EGCLSKLKAA
DPTFVMGHAM ATGLVLIGTG SSVKLDKELD LAVKTMVEIS RTQPLTRREQ LHVSAVETFA
NGNFPKACEL WEQILQDHPT DMLALKFSHD AYFYLGYQEQ MRDSVARIYP FWTPDIPLSS
YVKGIYSFGL METNFYDQAE KLAKEALSIN PTDAWSVHTV AHIHEMKAEI KDGLEFMQHS
ETFWKDSDML ACHNYWHWAL YLIEKGEYEA ALTIYDTHIL PSLQANDAML DVVDSCSMLY
RLQMEGVSVG QRWQDVLPVA RKHSRDHILL FNDAHFLMAS LGAHDPQTTQ ELLTTLRDAS
ESPGENCQHL LARDVGLPLC QALVEAEDGN PDRVLELLLP IRYRIVQLGG SNAQRDVFNQ
LLIHAALNCT SSVHKNVARS LLMERDALKP NSPLTERLIR KAATVHLMQ
