TTC38_MOUSE
ID TTC38_MOUSE Reviewed; 465 AA.
AC A3KMP2; Q05C02; Q05CK3; Q3UZU5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Tetratricopeptide repeat protein 38;
DE Short=TPR repeat protein 38;
GN Name=Ttc38;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Brain, Colon, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A3KMP2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A3KMP2-2; Sequence=VSP_031791;
CC -!- SIMILARITY: Belongs to the TTC38 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH24550.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH30849.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK133636; BAE21760.1; -; mRNA.
DR EMBL; BC024550; AAH24550.1; ALT_INIT; mRNA.
DR EMBL; BC030849; AAH30849.1; ALT_INIT; mRNA.
DR EMBL; BC132621; AAI32622.2; -; mRNA.
DR EMBL; BC132623; AAI32624.2; -; mRNA.
DR CCDS; CCDS27724.2; -. [A3KMP2-1]
DR RefSeq; NP_001028509.2; NM_001033337.4. [A3KMP2-1]
DR RefSeq; XP_006521015.1; XM_006520952.2. [A3KMP2-2]
DR RefSeq; XP_006521016.1; XM_006520953.3. [A3KMP2-2]
DR AlphaFoldDB; A3KMP2; -.
DR SMR; A3KMP2; -.
DR STRING; 10090.ENSMUSP00000114504; -.
DR iPTMnet; A3KMP2; -.
DR PhosphoSitePlus; A3KMP2; -.
DR SwissPalm; A3KMP2; -.
DR REPRODUCTION-2DPAGE; A3KMP2; -.
DR EPD; A3KMP2; -.
DR jPOST; A3KMP2; -.
DR MaxQB; A3KMP2; -.
DR PaxDb; A3KMP2; -.
DR PeptideAtlas; A3KMP2; -.
DR PRIDE; A3KMP2; -.
DR ProteomicsDB; 298008; -. [A3KMP2-1]
DR ProteomicsDB; 298009; -. [A3KMP2-2]
DR Antibodypedia; 28031; 47 antibodies from 14 providers.
DR Ensembl; ENSMUST00000146088; ENSMUSP00000114504; ENSMUSG00000035944. [A3KMP2-1]
DR GeneID; 239570; -.
DR KEGG; mmu:239570; -.
DR UCSC; uc007xdn.2; mouse. [A3KMP2-1]
DR CTD; 55020; -.
DR MGI; MGI:2146198; Ttc38.
DR VEuPathDB; HostDB:ENSMUSG00000035944; -.
DR eggNOG; KOG2610; Eukaryota.
DR GeneTree; ENSGT00390000002669; -.
DR HOGENOM; CLU_029972_1_1_1; -.
DR InParanoid; A3KMP2; -.
DR OMA; DAWGLHA; -.
DR OrthoDB; 824041at2759; -.
DR PhylomeDB; A3KMP2; -.
DR TreeFam; TF313343; -.
DR BioGRID-ORCS; 239570; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Ttc38; mouse.
DR PRO; PR:A3KMP2; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; A3KMP2; protein.
DR Bgee; ENSMUSG00000035944; Expressed in right kidney and 80 other tissues.
DR ExpressionAtlas; A3KMP2; baseline and differential.
DR Genevisible; A3KMP2; MM.
DR CDD; cd05804; StaR_like; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR033891; TTC38.
DR PANTHER; PTHR16263; PTHR16263; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..465
FT /note="Tetratricopeptide repeat protein 38"
FT /id="PRO_0000321531"
FT REPEAT 104..137
FT /note="TPR 1"
FT REPEAT 176..209
FT /note="TPR 2"
FT REPEAT 248..281
FT /note="TPR 3"
FT VAR_SEQ 1..186
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031791"
SQ SEQUENCE 465 AA; 52224 MW; 62E91019CBF010F3 CRC64;
MSLRDCQAWK NAGLPLSTTS NEACKLFDAT LTQYVKWTND KSLGGIEGCL SKLRAADPTF
AMGLAISNGL VLVGTGTSVA LDKDLALAVK TMVELSQTQT LTPREQLHVS AVEMFAKGNF
PRACDLWEQI LRDHPTDMLA LKFSHDAYFY LGYQEQMRDS VARVYPFWTP DIPLNSYVKG
IYSFGLMETN FYDQAQKLAK EALSIEPTDA WSVHTVAHVH EMRAEIKDGL EFMQQSEGHW
KDSDMLACHN YWHWALYLIE KGDYEAALTI YDSHILPSLQ ASGTMLDVVD SCSMLYRLQM
EGVPLGQRWQ TVLPVTQKHT RDHILLFNDA HFLMASLGAR DLQTTRELLT TLQEASKSPG
ENCQHQLAKD VGLPLCQALL EAENGNPDRV LELLLPIRYR IVQIGGSNAQ RDVFNQLLIH
AAMTCTSSVH KNVARSLLME RDALKPNSPL TERLIRRAAA VHLMQ
