TTC41_MOUSE
ID TTC41_MOUSE Reviewed; 1318 AA.
AC Q692V3; Q3TLE1; Q692V4; Q692V5; Q8K0V5;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Tetratricopeptide repeat protein 41 {ECO:0000312|MGI:MGI:2387653};
DE Short=TPR repeat protein 41 {ECO:0000305};
DE AltName: Full=Grp94-neighboring nucleotidase {ECO:0000303|PubMed:15827139};
GN Name=Ttc41 {ECO:0000312|MGI:MGI:2387653};
GN Synonyms=GNN {ECO:0000312|MGI:MGI:2387653};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4), SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC STRAIN=NIH Swiss;
RX PubMed=15827139; DOI=10.1128/jvi.79.9.5249-5258.2005;
RA van den Akker E., Vankan-Berkhoudt Y., Valk P.J.M., Loewenberg B.,
RA Delwel R.;
RT "The common viral insertion site Evi12 is located in the 5'-noncoding
RT region of Gnn, a novel gene with enhanced expression in two subclasses of
RT human acute myeloid leukemia.";
RL J. Virol. 79:5249-5258(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1297 (ISOFORM 3).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15827139}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
CC -!- SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=Gnn3;
CC IsoId=Q692V3-1; Sequence=Displayed;
CC Name=2; Synonyms=Gnn2;
CC IsoId=Q692V3-2; Sequence=VSP_034500, VSP_034501;
CC Name=3;
CC IsoId=Q692V3-3; Sequence=VSP_034497;
CC Name=4; Synonyms=Gnn1;
CC IsoId=Q692V3-4; Sequence=VSP_034498, VSP_034499;
CC -!- TISSUE SPECIFICITY: Highly expressed in lung and myeloid leukemia cell
CC line (at protein level). Isoform 4: expressed in heart (at protein
CC level). {ECO:0000269|PubMed:15827139}.
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DR EMBL; AY651019; AAT81231.1; -; mRNA.
DR EMBL; AY651020; AAT81232.1; -; mRNA.
DR EMBL; AY651021; AAT81233.1; -; mRNA.
DR EMBL; AK166553; BAE38851.1; -; mRNA.
DR EMBL; BC030307; AAH30307.1; -; mRNA.
DR CCDS; CCDS24098.1; -. [Q692V3-1]
DR CCDS; CCDS24099.1; -. [Q692V3-4]
DR CCDS; CCDS88066.1; -. [Q692V3-2]
DR RefSeq; NP_001003910.2; NM_001003910.2.
DR RefSeq; NP_001003939.2; NM_001003939.2.
DR AlphaFoldDB; Q692V3; -.
DR SMR; Q692V3; -.
DR STRING; 10090.ENSMUSP00000075059; -.
DR iPTMnet; Q692V3; -.
DR PhosphoSitePlus; Q692V3; -.
DR MaxQB; Q692V3; -.
DR PaxDb; Q692V3; -.
DR PRIDE; Q692V3; -.
DR ProteomicsDB; 298331; -. [Q692V3-1]
DR ProteomicsDB; 298332; -. [Q692V3-2]
DR ProteomicsDB; 298333; -. [Q692V3-3]
DR ProteomicsDB; 298334; -. [Q692V3-4]
DR DNASU; 103220; -.
DR GeneID; 103220; -.
DR KEGG; mmu:103220; -.
DR UCSC; uc007gqj.1; mouse. [Q692V3-4]
DR UCSC; uc007gql.1; mouse. [Q692V3-2]
DR UCSC; uc011xkv.1; mouse. [Q692V3-3]
DR CTD; 103220; -.
DR MGI; MGI:2387653; Ttc41.
DR eggNOG; ENOG502QUVD; Eukaryota.
DR InParanoid; Q692V3; -.
DR PhylomeDB; Q692V3; -.
DR BioGRID-ORCS; 103220; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Ttc41; mouse.
DR PRO; PR:Q692V3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q692V3; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF05729; NACHT; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1318
FT /note="Tetratricopeptide repeat protein 41"
FT /id="PRO_0000342550"
FT REPEAT 401..434
FT /note="TPR 1"
FT REPEAT 653..686
FT /note="TPR 2"
FT REPEAT 819..852
FT /note="TPR 3"
FT REPEAT 860..893
FT /note="TPR 4"
FT REPEAT 993..1029
FT /note="TPR 5"
FT REPEAT 1047..1084
FT /note="TPR 6"
FT REGION 1295..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..831
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034497"
FT VAR_SEQ 401..409
FT /note="PRLEMDFLN -> NRASLMGRK (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15827139"
FT /id="VSP_034498"
FT VAR_SEQ 410..1318
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15827139"
FT /id="VSP_034499"
FT VAR_SEQ 600
FT /note="P -> V (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15827139"
FT /id="VSP_034500"
FT VAR_SEQ 601..1318
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15827139"
FT /id="VSP_034501"
FT CONFLICT 139..140
FT /note="KK -> EQ (in Ref. 3; AAH30307)"
FT /evidence="ECO:0000305"
FT CONFLICT 355
FT /note="N -> D (in Ref. 1; AAT81232)"
FT /evidence="ECO:0000305"
FT CONFLICT 917
FT /note="E -> K (in Ref. 2; BAE38851)"
FT /evidence="ECO:0000305"
FT CONFLICT 1263
FT /note="R -> L (in Ref. 2; BAE38851)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1318 AA; 150823 MW; DED7377763676059 CRC64;
MSDEASETGQ RYNGQPILKR QKPILPYICS TLDFQEERDF LAKSIFPRLN DICSSRGTYF
KAVDLRWSAV KAHKSFTSNQ FRQYSCLQSQ HLKLSLDYVN RCFPFFIGLL GQTYGDFLPD
YTPFLLSQVK DFESLSKGKK NLYIAAKNGY PWVLKTPNCS LTEFEIIQAV FRKKSQFQFF
YFRTSNSLLR TFNEEEEEEE EKLSSAYLLN EQGKMKVGKL KAKIIGKGLP VRFYRDLEEL
GDMVWKDWSA VVEKLYPFTT IMGNIDYKHS FENLYHEEFV ENCKQVFVTS KESNRTFEIL
ERFAIKDLDL DLDTDSTIAG SGLDSILRIN SLPTCKSILL LSGERGCGKS TLIANWVSNF
QSKHPGVLMI PYFVGSTCES CDIMSVIHYF VMELQHRANG PRLEMDFLNE DSNVLVFSLL
VEVFIAAISL KPCILVLDGI EELIGIYGIS GQKAKDFSWL PRSLPPHCKF ILSSVSSSLS
CKSLCARPDV KIVELNSIGD EDTKFNIFRQ HLSPADQERF GQSKPILRKK PNLSPLKLAI
IASELQECKI YRNEFQCLRE YLEVASVQEL WELILKRWVE DYSWTLKPKD TTLDTVIPGP
SGWVVDVLCL LCISHCGLAE DELLQLLDTM GYRDHHKVTA VHWAAFRQAT KTWIQEKPNG
LLYFQHQSLR SAVEHKLLGV STPVRESNPN VAQNSVNHKK AHFHQVLMRF FQRQTIFWRV
YQELPWHMKM SGYWEGLCNF ITNPSITDFI SKIQNPSLWT RLHLVHYWDV LLEAGNDVSE
AFLLSVAKIE GEQFQKLKKR TTLSVLECSL SEITAADKGR IILFIGSFLK LMGKINEAEK
LFLSAEDLLL QSPSMTEMLL RAQNAIGELY LEIGMTPKGL TYFQKAWSNL LRFTLSDLKI
SQELMKQKVK VMNNLAESAP GEFLKENHVL EYATEISKYV TGNPRDHATM KYTEGVLMLA
SGNAALAKLK FQECLTIRRW LFGNKNILVG EIMEFLADLL FFLLGENEKS QKKQAIEYYK
QVIKIKEKAD TVATCKLVRK HLSISLSDTL CKLAGQLLSG DFCHHATMEA VSYLYRSLDL
RAAHLGPTHA SIEGILHLLR EIQRSRGRRS WPQSMNHLFP NGSRNGFSLW ENVPKLNFHS
AQSSDTVNTA MCMNIRRFQR VKSTQPSLVS DKPKYVPGKG KKTLAPILCK SAEEKFQRQA
SDSQIWNSPR RQPARKKAAC PLKTVSLIDK NGLVRLSRQS VSSAELDSRK GLITSICRQP
LQRPHNVDNP WKSISELVSE KWLFHTPQYC FTPQKPGFPR RSQIESKLLK TSDDPNKE
