ID   TTC4_BOVIN              Reviewed;         388 AA.
AC   Q5EA11; A5D7E7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Tetratricopeptide repeat protein 4;
DE            Short=TPR repeat protein 4;
GN   Name=TTC4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a co-chaperone for HSP90AB1 (By similarity).
CC       {ECO:0000250|UniProtKB:O95801}.
CC   -!- SUBUNIT: Interacts (via TPR repeats) with HSP90AB1 (By similarity).
CC       Interacts with HSPA8, CDC6, TBK1 and MSL1 (By similarity).
CC       {ECO:0000250|UniProtKB:O95801}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95801}. Nucleus,
CC       nucleoplasm {ECO:0000250|UniProtKB:O95801}. Cytoplasm
CC       {ECO:0000250|UniProtKB:O95801}. Note=Predominantly nuclear in the G1
CC       and S phases of cell cycle and is evenly distributed between the
CC       nucleus and cytoplasm in the G2 phase. MSL1 can promote its nuclear
CC       localization (By similarity). {ECO:0000250|UniProtKB:Q8R3H9}.
CC   -!- SIMILARITY: Belongs to the TTC4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX08775.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BT020758; AAX08775.1; ALT_INIT; mRNA.
DR   EMBL; BC140528; AAI40529.1; -; mRNA.
DR   RefSeq; NP_001015554.1; NM_001015554.1.
DR   AlphaFoldDB; Q5EA11; -.
DR   SMR; Q5EA11; -.
DR   STRING; 9913.ENSBTAP00000021186; -.
DR   PaxDb; Q5EA11; -.
DR   PRIDE; Q5EA11; -.
DR   GeneID; 509047; -.
DR   KEGG; bta:509047; -.
DR   CTD; 7268; -.
DR   eggNOG; KOG0551; Eukaryota.
DR   InParanoid; Q5EA11; -.
DR   OrthoDB; 866891at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0030544; F:Hsp70 protein binding; IBA:GO_Central.
DR   GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR044059; Csn1/TTC4_wheel.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF18972; Wheel; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Antiviral defense; Cytoplasm; Immunity; Innate immunity;
KW   Nucleus; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..388
FT                   /note="Tetratricopeptide repeat protein 4"
FT                   /id="PRO_0000328163"
FT   REPEAT          79..112
FT                   /note="TPR 1"
FT   REPEAT          117..150
FT                   /note="TPR 2"
FT   REPEAT          151..184
FT                   /note="TPR 3"
FT   SITE            152
FT                   /note="Essential for interaction with HSPA8"
FT                   /evidence="ECO:0000250|UniProtKB:O95801"
FT   SITE            156
FT                   /note="Essential for interaction with HSPA8"
FT                   /evidence="ECO:0000250|UniProtKB:O95801"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:O95801"
FT   MOD_RES         51
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O95801"
FT   MOD_RES         244
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O95801"
FT   CONFLICT        255
FT                   /note="Y -> H (in Ref. 2; AAI40529)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        258
FT                   /note="S -> G (in Ref. 2; AAI40529)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        286
FT                   /note="Y -> H (in Ref. 2; AAI40529)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        318
FT                   /note="E -> D (in Ref. 2; AAI40529)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   388 AA;  44373 MW;  850CC232DA4410BF CRC64;
     MEQQEPGATL DDGMDSFLEK FQSQPYRGGF HESQWEEEFE KIPLFMKNSP SEIDPLENPD
     LACLQSIIFD EERSPEDQAR TYKDEGNDYF KEKDYKKAVI SYTEGLKKKC ADPDLNAVLY
     TNRAAAQYYL GNFRSSLNDV TAARKLKPCH LKAIIRGASC HLELKNYVEA VNWCDEGLQI
     DATEKKLLDL RAKADKLKRT EQRDVRKAKL KEKKQQDQNE ALLQAIKARN IRLVAEAAGE
     DEDSASEGLS ELVLYGLSSE NPCGARLGVD DQGRLSWPVL FLYPEYAQSD LVSAFHEDSR
     FIDHLMVMFG ETPSWDLEQK YCPDNLEVYF EDEDRAELYC VPPSSTLLQV LQHPRYFVKA
     LTPTFLVCVG SSGFCRNYLR GKKVHQVK