ID   TTC4_DICDI              Reviewed;         397 AA.
AC   Q54M20;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Tetratricopeptide repeat protein 4 homolog;
DE            Short=TPR repeat protein 4 homolog;
GN   Name=ttc4; ORFNames=DDB_G0286253;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the TTC4 family. {ECO:0000305}.
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DR   EMBL; AAFI02000085; EAL64302.1; -; Genomic_DNA.
DR   RefSeq; XP_637811.1; XM_632719.1.
DR   AlphaFoldDB; Q54M20; -.
DR   SMR; Q54M20; -.
DR   STRING; 44689.DDB0305005; -.
DR   PaxDb; Q54M20; -.
DR   PRIDE; Q54M20; -.
DR   EnsemblProtists; EAL64302; EAL64302; DDB_G0286253.
DR   GeneID; 8625525; -.
DR   KEGG; ddi:DDB_G0286253; -.
DR   dictyBase; DDB_G0286253; ttc4.
DR   eggNOG; KOG0551; Eukaryota.
DR   HOGENOM; CLU_040446_1_0_1; -.
DR   InParanoid; Q54M20; -.
DR   OMA; HPMFEGL; -.
DR   PhylomeDB; Q54M20; -.
DR   PRO; PR:Q54M20; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030544; F:Hsp70 protein binding; IBA:GO_Central.
DR   GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR044059; Csn1/TTC4_wheel.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF18972; Wheel; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..397
FT                   /note="Tetratricopeptide repeat protein 4 homolog"
FT                   /id="PRO_0000328162"
FT   REPEAT          90..125
FT                   /note="TPR 1"
FT   REPEAT          130..163
FT                   /note="TPR 2"
FT   REPEAT          164..197
FT                   /note="TPR 3"
SQ   SEQUENCE   397 AA;  46871 MW;  495D6418929234CA CRC64;
     MSTADATGGL TEEEENILWE RSVIAWKQQK EERKKSNQEL IDRGEKPIDY DNDWKDLPIF
     MQELPEEPSS NQYLAAFQSL SNDCTPEERA ETFKNLGNDY FREGKSRFND ALYYYNKALS
     VKCNDMTKNS IYLSNRAAIN MELGNYGLVI KDCTVSVEFN PLNMKAYSRM ARAQLQLSKY
     QDSIKTCDLG LSHEPTNKDL STIRENANKK LQDIKKREQD KIDKENQLKQ QQQLLATKLY
     EKNKYKLGHQ IFDMSQYTYQ SDRKVTIDQN NDVHFPVVFL YPEFGKSDFI MDFQEDHTFG
     DHLQMMFPPE NPEFAPWDTK KEYTMDRIEV YFETNWTKPI LSDIKIKEIE KKWIRVKHTT
     DIAKVISHPT YIIPEIPIFY IVSRGNLFYK KFLENKL