TTC7B_MOUSE
ID TTC7B_MOUSE Reviewed; 843 AA.
AC E9Q6P5;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Tetratricopeptide repeat protein 7B;
DE Short=TPR repeat protein 7B;
GN Name=Ttc7b {ECO:0000312|MGI:MGI:2144724};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-677 AND SER-678, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160; SER-202; SER-625;
RP SER-629; SER-630; SER-673; SER-677; SER-678 AND SER-681, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of a complex required to localize
CC phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The
CC complex acts as a regulator of phosphatidylinositol 4-phosphate
CC (PtdIns(4)P) synthesis. In the complex, plays a central role in
CC bridging PI4KA to EFR3B and FAM126A, via direct interactions.
CC {ECO:0000250|UniProtKB:Q86TV6}.
CC -!- SUBUNIT: Component of a phosphatidylinositol 4-kinase (PI4K) complex,
CC composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and
CC FAM126 (FAM126A or FAM126B). Interacts with PI4KA, interaction is
CC direct. Interacts with EFR3 (EFR3A or EFR3B), interaction is direct.
CC Interacts with FAM126 (FAM126A or FAM126B), interaction is direct.
CC Association with the PI4K complex is strongly reduced by TMEM150A.
CC {ECO:0000250|UniProtKB:Q86TV6}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q86TV6}. Cell membrane
CC {ECO:0000250|UniProtKB:Q86TV6}. Note=Localizes to the cytosol and is
CC recruited to the plasma membrane following interaction with EFR3 (EFR3A
CC or EFR3B). {ECO:0000250|UniProtKB:Q86TV6}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC123705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC159633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC160340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS49141.1; -.
DR RefSeq; NP_001028385.1; NM_001033213.1.
DR AlphaFoldDB; E9Q6P5; -.
DR SMR; E9Q6P5; -.
DR IntAct; E9Q6P5; 1.
DR MINT; E9Q6P5; -.
DR STRING; 10090.ENSMUSP00000052107; -.
DR iPTMnet; E9Q6P5; -.
DR PhosphoSitePlus; E9Q6P5; -.
DR SwissPalm; E9Q6P5; -.
DR EPD; E9Q6P5; -.
DR jPOST; E9Q6P5; -.
DR MaxQB; E9Q6P5; -.
DR PaxDb; E9Q6P5; -.
DR PeptideAtlas; E9Q6P5; -.
DR PRIDE; E9Q6P5; -.
DR ProteomicsDB; 300157; -.
DR Antibodypedia; 26548; 24 antibodies from 13 providers.
DR Ensembl; ENSMUST00000062957; ENSMUSP00000052107; ENSMUSG00000033530.
DR GeneID; 104718; -.
DR KEGG; mmu:104718; -.
DR UCSC; uc007oss.2; mouse.
DR CTD; 145567; -.
DR MGI; MGI:2144724; Ttc7b.
DR VEuPathDB; HostDB:ENSMUSG00000033530; -.
DR eggNOG; KOG4162; Eukaryota.
DR GeneTree; ENSGT00940000158474; -.
DR HOGENOM; CLU_010512_1_0_1; -.
DR InParanoid; E9Q6P5; -.
DR OMA; PRNEYEE; -.
DR OrthoDB; 167932at2759; -.
DR PhylomeDB; E9Q6P5; -.
DR TreeFam; TF313783; -.
DR BioGRID-ORCS; 104718; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Ttc7b; mouse.
DR PRO; PR:E9Q6P5; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; E9Q6P5; protein.
DR Bgee; ENSMUSG00000033530; Expressed in subiculum and 235 other tissues.
DR ExpressionAtlas; E9Q6P5; baseline and differential.
DR Genevisible; E9Q6P5; MM.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; ISS:UniProtKB.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR045819; TTC7_N.
DR Pfam; PF07719; TPR_2; 1.
DR Pfam; PF13181; TPR_8; 2.
DR Pfam; PF19440; TTC7_N; 1.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; TPR repeat.
FT CHAIN 1..843
FT /note="Tetratricopeptide repeat protein 7B"
FT /id="PRO_0000435631"
FT REPEAT 97..131
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 219..252
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 363..396
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT REPEAT 397..430
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT REPEAT 479..514
FT /note="TPR 5"
FT /evidence="ECO:0000255"
FT REPEAT 516..548
FT /note="TPR 6"
FT /evidence="ECO:0000255"
FT REPEAT 549..582
FT /note="TPR 7"
FT /evidence="ECO:0000255"
FT REPEAT 696..729
FT /note="TPR 8"
FT /evidence="ECO:0000255"
FT REPEAT 730..763
FT /note="TPR 9"
FT /evidence="ECO:0000255"
FT REPEAT 765..797
FT /note="TPR 10"
FT /evidence="ECO:0000255"
FT REPEAT 798..831
FT /note="TPR 11"
FT /evidence="ECO:0000255"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 202
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 625
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 629
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 630
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 673
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 677
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 678
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 681
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 843 AA; 94203 MW; D03FC98FF4FA7156 CRC64;
MATRKAGSRL ETEIERCRSE CQWERIPELV KQLSAKLIAN DDMAELLLGE SKLEQHLKEK
PLRQGASPRG PRPQLTEVRK HLTAALDRGN LKSEFLQESN LVMAKLTYVE GDYKEALNIY
ARVGLDDLPL TAVPPYRLRM IAEAYATKGL CLEKLPVSSS TSNLHVDREQ DVITCYEKAG
DIALLYLQEI ERVMLTNIQN RSPKPGPAPH DQELGFFLET GLQRAHVLYF KNGNLTRGVG
RFRELLRAVE TRTTQNLRMT IARQLAEILL RGMCEQSYWS PLEEPPYQSP LDDPLRKGAN
TKAYTLPRRA RVYSGENIFC PQENTEEALL LLLISESMAN RDAVLSRIPE HKSDRLISLQ
SASVVYDLLT IALGRRGQYE MLSECLERAM KFAFEEFHLW YQFALSLMAA GKSARAVKVL
KECIRLKPDD ATIPLLAAKL CVGSLHWLEE AEKFAKTVVD VGEKTSEFKA KGYLALGLTY
SLQATDASLR GMQEGLQRKA LLAFQRAHSL SPTDHQAAFY LALQLAISRQ IPEALGYVRQ
ALQLQGDDAN SLHLLALLLS AQKHYHDALN IIDMALSEYP ENFILLFSKV KLESLCRGPD
EALLTCKHML QIWKSCYNLT NPSDSGRGSS LLDRTIADRR QLNTITLPDF SDPETGSVHA
TSVAASRVEQ ALSEVASSLQ SSAPKQGPLH PWMTLAQIWL HAAEVYIGIG KPAEATACTQ
EAANLFPMSH NVLYMRGQVA ELRGHFDEAR RWYEEALSIS PTHVKSMQRL ALVLHQLGRY
SLAEKILRDA VQVNSTAHEV WNGLGEVLQA QGNDAAATEC FLTALELEAS SPAVPFTVIP
RVL
