TTC9A_MOUSE
ID TTC9A_MOUSE Reviewed; 219 AA.
AC Q3V038; B2RTC7; Q3TTA0; Q6A0A0; Q8K336;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Tetratricopeptide repeat protein 9A;
DE Short=TPR repeat protein 9A;
GN Name=Ttc9; Synonyms=Kiaa0227, Ttc9a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the TTC9 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH28891.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAD32196.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK172918; BAD32196.1; ALT_INIT; mRNA.
DR EMBL; AK133456; BAE21667.1; -; mRNA.
DR EMBL; AK161499; BAE36425.1; -; mRNA.
DR EMBL; BC028891; AAH28891.1; ALT_INIT; mRNA.
DR EMBL; BC139242; AAI39243.1; -; mRNA.
DR EMBL; BC139244; AAI39245.1; -; mRNA.
DR CCDS; CCDS26024.1; -.
DR RefSeq; NP_001028321.1; NM_001033149.3.
DR AlphaFoldDB; Q3V038; -.
DR SMR; Q3V038; -.
DR STRING; 10090.ENSMUSP00000048590; -.
DR iPTMnet; Q3V038; -.
DR PhosphoSitePlus; Q3V038; -.
DR MaxQB; Q3V038; -.
DR PaxDb; Q3V038; -.
DR PeptideAtlas; Q3V038; -.
DR PRIDE; Q3V038; -.
DR ProteomicsDB; 297676; -.
DR Antibodypedia; 55304; 1 antibodies from 1 providers.
DR Ensembl; ENSMUST00000036116; ENSMUSP00000048590; ENSMUSG00000042734.
DR Ensembl; ENSMUST00000218362; ENSMUSP00000152038; ENSMUSG00000042734.
DR GeneID; 69480; -.
DR KEGG; mmu:69480; -.
DR UCSC; uc007ocm.1; mouse.
DR CTD; 23508; -.
DR MGI; MGI:1916730; Ttc9.
DR VEuPathDB; HostDB:ENSMUSG00000042734; -.
DR eggNOG; ENOG502QZUJ; Eukaryota.
DR GeneTree; ENSGT00940000161472; -.
DR HOGENOM; CLU_100621_0_0_1; -.
DR InParanoid; Q3V038; -.
DR OMA; CHGRHEA; -.
DR OrthoDB; 1535136at2759; -.
DR PhylomeDB; Q3V038; -.
DR TreeFam; TF331917; -.
DR BioGRID-ORCS; 69480; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Ttc9; mouse.
DR PRO; PR:Q3V038; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q3V038; protein.
DR Bgee; ENSMUSG00000042734; Expressed in substantia nigra and 158 other tissues.
DR Genevisible; Q3V038; MM.
DR GO; GO:0060348; P:bone development; IDA:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF00515; TPR_1; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..219
FT /note="Tetratricopeptide repeat protein 9A"
FT /id="PRO_0000294470"
FT REPEAT 56..89
FT /note="TPR 1"
FT REPEAT 125..160
FT /note="TPR 2"
FT REPEAT 161..194
FT /note="TPR 3"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..34
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 102
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92623"
SQ SEQUENCE 219 AA; 24351 MW; 95949287036C10FD CRC64;
MERKGLAARS SGNPSPPALG EGPRPVPPPC VPSGGGAPER GQAGTAAEPA ELIRRAHEFK
SQGAQCYKDK KFREAIGKYH RALLELKGLL PSQEERDARP ASSAGVPKSS RLSEEQSKTV
EAIEIDCYNS LAACLLQAEL VNYERVKEYC LKVLKKEGEN FKALYRSGVA FYHLGDYDKA
LYYLKEARTR QPTDTNVIRY IQLTEMKLSR CSQREKEAM
