TTC9C_HUMAN
ID TTC9C_HUMAN Reviewed; 171 AA.
AC Q8N5M4; Q8WYY7;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Tetratricopeptide repeat protein 9C;
DE Short=TPR repeat protein 9C;
GN Name=TTC9C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Zhou X.M., Zhang P.P., Jiang H.Q., Huang Y., Qin W.X., Zhao X.T., Wan D.F.,
RA Gu J.R.;
RT "Novel human cDNA clones with function of inhibiting cancer cell growth.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RA Zan Q., Guo J.H., Yu L.;
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=B-cell, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q8N5M4; Q9Y232-2: CDYL; NbExp=3; IntAct=EBI-2851213, EBI-10986891;
CC Q8N5M4; Q08379: GOLGA2; NbExp=3; IntAct=EBI-2851213, EBI-618309;
CC Q8N5M4; O75031: HSF2BP; NbExp=3; IntAct=EBI-2851213, EBI-7116203;
CC Q8N5M4; Q15323: KRT31; NbExp=3; IntAct=EBI-2851213, EBI-948001;
CC Q8N5M4; O76011: KRT34; NbExp=3; IntAct=EBI-2851213, EBI-1047093;
CC Q8N5M4; Q6A162: KRT40; NbExp=3; IntAct=EBI-2851213, EBI-10171697;
CC Q8N5M4; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-2851213, EBI-1216080;
CC Q8N5M4; P50222: MEOX2; NbExp=3; IntAct=EBI-2851213, EBI-748397;
CC Q8N5M4; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-2851213, EBI-16439278;
CC Q8N5M4; Q9BSH3: NICN1; NbExp=3; IntAct=EBI-2851213, EBI-13324229;
CC Q8N5M4; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-2851213, EBI-742388;
CC Q8N5M4; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-2851213, EBI-302345;
CC Q8N5M4; P63208: SKP1; NbExp=10; IntAct=EBI-2851213, EBI-307486;
CC Q8N5M4; O75478: TADA2A; NbExp=3; IntAct=EBI-2851213, EBI-742268;
CC Q8N5M4; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-2851213, EBI-74615;
CC Q8N5M4; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-2851213, EBI-2130429;
CC Q8N5M4; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-2851213, EBI-739895;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N5M4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N5M4-2; Sequence=VSP_056610, VSP_056611;
CC -!- SIMILARITY: Belongs to the TTC9 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF289605; AAL55789.1; -; mRNA.
DR EMBL; AF451992; AAP97691.1; -; mRNA.
DR EMBL; AF451993; AAP97692.1; -; mRNA.
DR EMBL; AP001160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032123; AAH32123.1; -; mRNA.
DR EMBL; BC053665; AAH53665.1; -; mRNA.
DR CCDS; CCDS8033.1; -. [Q8N5M4-1]
DR RefSeq; NP_001305741.1; NM_001318812.1. [Q8N5M4-1]
DR RefSeq; NP_001305742.1; NM_001318813.1. [Q8N5M4-1]
DR RefSeq; NP_001305743.1; NM_001318814.1.
DR RefSeq; NP_001305744.1; NM_001318815.1.
DR RefSeq; NP_001305745.1; NM_001318816.1.
DR RefSeq; NP_776171.1; NM_173810.3. [Q8N5M4-1]
DR AlphaFoldDB; Q8N5M4; -.
DR SMR; Q8N5M4; -.
DR BioGRID; 129507; 138.
DR IntAct; Q8N5M4; 45.
DR STRING; 9606.ENSP00000325266; -.
DR GlyGen; Q8N5M4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N5M4; -.
DR PhosphoSitePlus; Q8N5M4; -.
DR BioMuta; TTC9C; -.
DR DMDM; 74759911; -.
DR EPD; Q8N5M4; -.
DR jPOST; Q8N5M4; -.
DR MassIVE; Q8N5M4; -.
DR MaxQB; Q8N5M4; -.
DR PaxDb; Q8N5M4; -.
DR PeptideAtlas; Q8N5M4; -.
DR PRIDE; Q8N5M4; -.
DR ProteomicsDB; 72075; -. [Q8N5M4-1]
DR ProteomicsDB; 75201; -.
DR Antibodypedia; 43795; 105 antibodies from 17 providers.
DR DNASU; 283237; -.
DR Ensembl; ENST00000316461.9; ENSP00000325266.3; ENSG00000162222.14. [Q8N5M4-1]
DR Ensembl; ENST00000532583.1; ENSP00000434340.1; ENSG00000162222.14. [Q8N5M4-1]
DR GeneID; 283237; -.
DR KEGG; hsa:283237; -.
DR MANE-Select; ENST00000316461.9; ENSP00000325266.3; NM_173810.4; NP_776171.1.
DR UCSC; uc001nuy.4; human. [Q8N5M4-1]
DR CTD; 283237; -.
DR DisGeNET; 283237; -.
DR GeneCards; TTC9C; -.
DR HGNC; HGNC:28432; TTC9C.
DR HPA; ENSG00000162222; Low tissue specificity.
DR neXtProt; NX_Q8N5M4; -.
DR OpenTargets; ENSG00000162222; -.
DR PharmGKB; PA142670685; -.
DR VEuPathDB; HostDB:ENSG00000162222; -.
DR eggNOG; ENOG502RXZG; Eukaryota.
DR GeneTree; ENSGT00940000161805; -.
DR InParanoid; Q8N5M4; -.
DR OMA; YHQKEKQ; -.
DR OrthoDB; 1535136at2759; -.
DR PhylomeDB; Q8N5M4; -.
DR TreeFam; TF331917; -.
DR PathwayCommons; Q8N5M4; -.
DR SignaLink; Q8N5M4; -.
DR BioGRID-ORCS; 283237; 19 hits in 1085 CRISPR screens.
DR ChiTaRS; TTC9C; human.
DR GenomeRNAi; 283237; -.
DR Pharos; Q8N5M4; Tdark.
DR PRO; PR:Q8N5M4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N5M4; protein.
DR Bgee; ENSG00000162222; Expressed in stromal cell of endometrium and 163 other tissues.
DR ExpressionAtlas; Q8N5M4; baseline and differential.
DR Genevisible; Q8N5M4; HS.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..171
FT /note="Tetratricopeptide repeat protein 9C"
FT /id="PRO_0000294465"
FT REPEAT 8..41
FT /note="TPR 1"
FT REPEAT 72..107
FT /note="TPR 2"
FT REPEAT 108..141
FT /note="TPR 3"
FT VAR_SEQ 1
FT /note="M -> MLNKEEELELLEALWSFSTSPAHSLLLPGRGGAGPIERRKPVSQAFS
FT RPQQFLSRALLEFFGKSHPPPHRLFRKSLNVGLHYSHIPFLTTCLHFLRKRLQKGEVGL
FT SVETSKPQVPVGGLSRKKVPQEPWATVM (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_056610"
FT VAR_SEQ 80..171
FT /note="ACLLQMEPVNYERVREYSQKVLERQPDNAKALYRAGVAFFHLQDYDQARHYL
FT LAAVNRQPKDANVRRYLQLTQSELSSYHRKEKQLYLGMFG -> VVK (in isoform
FT 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_056611"
SQ SEQUENCE 171 AA; 20013 MW; A583DFC56CD3346E CRC64;
MEKRLQEAQL YKEEGNQRYR EGKYRDAVSR YHRALLQLRG LDPSLPSPLP NLGPQGPALT
PEQENILHTT QTDCYNNLAA CLLQMEPVNY ERVREYSQKV LERQPDNAKA LYRAGVAFFH
LQDYDQARHY LLAAVNRQPK DANVRRYLQL TQSELSSYHR KEKQLYLGMF G
