ID   C4_VACCW                Reviewed;         316 AA.
AC   P17370; Q80HY4;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2012, sequence version 2.
DT   23-FEB-2022, entry version 57.
DE   RecName: Full=Protein C4;
GN   OrderedLocusNames=VACWR024; ORFNames=C4L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2849238; DOI=10.1016/s0042-6822(88)90115-8;
RA   Kotwal G.J., Moss B.;
RT   "Analysis of a large cluster of nonessential genes deleted from a vaccinia
RT   virus terminal transposition mutant.";
RL   Virology 167:524-537(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=22791606; DOI=10.1099/vir.0.045070-0;
RA   Ember S.W., Ren H., Ferguson B.J., Smith G.L.;
RT   "Vaccinia virus protein C4 inhibits NF-kappaB activation and promotes virus
RT   virulence.";
RL   J. Gen. Virol. 93:2098-2108(2012).
CC   -!- FUNCTION: Plays a role in the inhibition of host NF-kappa-B activation.
CC       Mechanistically, blocks the subunit p65/RELA translocation into the
CC       host nucleus. {ECO:0000269|PubMed:22791606}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:22791606}.
CC       Host nucleus {ECO:0000269|PubMed:22791606}.
CC   -!- SIMILARITY: Belongs to the poxviridae C4/C10 protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA69604.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; M22812; AAA69604.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AY243312; AAO89303.1; -; Genomic_DNA.
DR   PIR; D33348; WZVZB4.
DR   RefSeq; YP_232906.1; NC_006998.1.
DR   DNASU; 3707639; -.
DR   GeneID; 3707639; -.
DR   KEGG; vg:3707639; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IDA:UniProtKB.
DR   GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IDA:UniProtKB.
DR   InterPro; IPR005004; Poxvirus_C4/C10.
DR   Pfam; PF03336; Pox_C4_C10; 1.
DR   PIRSF; PIRSF003698; VAC_C10L; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Host nucleus; Reference proteome.
FT   CHAIN           1..316
FT                   /note="Protein C4"
FT                   /id="PRO_0000099378"
SQ   SEQUENCE   316 AA;  37215 MW;  CB814F455EC66245 CRC64;
     MDTIKIFNHG EFDTIRNELV NLLKVVKWNT INSNVTVSST DTIDISDCIR EILYKQFKNV
     RNIEVSSDIS FIKYNRFNDT TLTDDNVGYY LVIYLNRTKS VKTLIYPTPE TVITSSEDIM
     FSKSLNFRFE NVKRDYKLVM CSISLTYKPS ICRIQYDNNK YLDISDSQEC NNLCYCVITM
     DPHHLIDLET ICVLVDKSGK CLLVNEFYIR FRKNHIYNSF ADLCMDHIFE LPNTKELFTL
     RNDDGRNIAW DNDKLESGNN TWIPKTDDEY KFLSKLMNIA KFNNTKFDYY VLVGDTDPCT
     VFTFKVTKYY INLNYE