ID   C5082_DICDI             Reviewed;         493 AA.
AC   Q556M4; Q86AL5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Probable cytochrome P450 508A2;
DE            EC=1.14.-.-;
GN   Name=cyp508A2-1; ORFNames=DDB_G0272604;
GN   and
GN   Name=cyp508A2-2; ORFNames=DDB_G0273945;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC       AX4. These strains contain a duplication of a segment of 750 kb of
CC       chromosome 2 compared to the corresponding sequence in strain AX2.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000011; EAL70406.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70939.1; -; Genomic_DNA.
DR   RefSeq; XP_644331.1; XM_639239.1.
DR   RefSeq; XP_645083.1; XM_639991.1.
DR   AlphaFoldDB; Q556M4; -.
DR   SMR; Q556M4; -.
DR   STRING; 44689.DDB0232345; -.
DR   PaxDb; Q556M4; -.
DR   EnsemblProtists; EAL70406; EAL70406; DDB_G0273945.
DR   EnsemblProtists; EAL70939; EAL70939; DDB_G0272604.
DR   GeneID; 8618757; -.
DR   GeneID; 8619219; -.
DR   KEGG; ddi:DDB_G0272604; -.
DR   KEGG; ddi:DDB_G0273945; -.
DR   dictyBase; DDB_G0272604; cyp508A2-1.
DR   dictyBase; DDB_G0273945; cyp508A2-2.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_001570_4_0_1; -.
DR   InParanoid; Q556M4; -.
DR   OMA; EPCIQQG; -.
DR   PhylomeDB; Q556M4; -.
DR   Reactome; R-DDI-211935; Fatty acids.
DR   Reactome; R-DDI-211958; Miscellaneous substrates.
DR   Reactome; R-DDI-211981; Xenobiotics.
DR   Reactome; R-DDI-211999; CYP2E1 reactions.
DR   Reactome; R-DDI-2142670; Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
DR   Reactome; R-DDI-2142816; Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
DR   Reactome; R-DDI-5423646; Aflatoxin activation and detoxification.
DR   Reactome; R-DDI-9027307; Biosynthesis of maresin-like SPMs.
DR   Reactome; R-DDI-9749641; Aspirin ADME.
DR   Reactome; R-DDI-9753281; Paracetamol ADME.
DR   PRO; PR:Q556M4; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
DR   GO; GO:0006082; P:organic acid metabolic process; IBA:GO_Central.
DR   GO; GO:0006805; P:xenobiotic metabolic process; IBA:GO_Central.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..493
FT                   /note="Probable cytochrome P450 508A2"
FT                   /id="PRO_0000318807"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         439
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   493 AA;  56819 MW;  4AF1DAEA5E89F758 CRC64;
     MIFGIIVYLF LIYILHNAYS KYKRLNENQL PGPFPIPILG NIYQLTNLPH FDLTKMSEKY
     GKIFRIYLAD LYTVIVCDPI IARELFVDKF DNFIDRPKIP SVKHGTFYHG TVASMGDNWK
     NNKEIVGKAM RKTNLKHIYQ LLDDQVDVLI ESMRTIESSG ETFDPRYYLT KFTMSAMFKY
     IFNEDISKDE DVHNGQLAQL MKPMQKVFKD FGTGSLFDVL EITRPLYFLY LEWFTSHYYQ
     VINFGKMKIY KHLETYKPDV QRDLMDLLIK EYGTETDDQI LSISATVSDF FLAGVDTSAT
     SLELIVMMLI NYPEYQEKAY NEIKSALSSN GGGGGGGLTQ RNKVLLSDRQ STPFVVSLFK
     ETLRYKPISP FGLPRSTTSD IILNNGQFIP KNAQILINYH ALSRNEEYFE NPNQFDPTRF
     LNSDSNPAFM PFSIGPRNCV GSNFAQDEIY IALSNMILNF KFKSIDGKPV DETQTYGLTL
     KPNPFKVILE KRK