ID   TTDB_ECO57              Reviewed;         201 AA.
AC   Q8XBK5;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=L(+)-tartrate dehydratase subunit beta;
DE            Short=L-TTD beta;
DE            EC=4.2.1.32;
GN   Name=ttdB; OrderedLocusNames=Z4415, ECs3945;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R,3R)-tartrate = H2O + oxaloacetate; Xref=Rhea:RHEA:15413,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:16452, ChEBI:CHEBI:30924; EC=4.2.1.32;
CC   -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Induced by tartrate, via TtdR. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-I fumarase family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG58196.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37368.1; -; Genomic_DNA.
DR   PIR; A91122; A91122.
DR   PIR; H85966; H85966.
DR   RefSeq; NP_311972.1; NC_002695.1.
DR   RefSeq; WP_000722948.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8XBK5; -.
DR   SMR; Q8XBK5; -.
DR   STRING; 155864.EDL933_4283; -.
DR   EnsemblBacteria; AAG58196; AAG58196; Z4415.
DR   EnsemblBacteria; BAB37368; BAB37368; ECs_3945.
DR   GeneID; 916229; -.
DR   KEGG; ece:Z4415; -.
DR   KEGG; ecs:ECs_3945; -.
DR   PATRIC; fig|386585.9.peg.4115; -.
DR   eggNOG; COG1838; Bacteria.
DR   HOGENOM; CLU_098588_0_0_6; -.
DR   OMA; IYHCGPL; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0008730; F:L(+)-tartrate dehydratase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.20.130.10; -; 1.
DR   InterPro; IPR004647; Fe-S_hydro-lyase_TtdB-typ_cat.
DR   InterPro; IPR036660; Fe-S_hydroAse_TtdB_cat_sf.
DR   Pfam; PF05683; Fumerase_C; 1.
DR   SUPFAM; SSF117457; SSF117457; 1.
DR   TIGRFAMs; TIGR00723; ttdB_fumA_fumB; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..201
FT                   /note="L(+)-tartrate dehydratase subunit beta"
FT                   /id="PRO_0000195665"
FT   ACT_SITE        37
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   201 AA;  22660 MW;  451BA605C388F157 CRC64;
     MKKILTTPIK AEDLQDIHVG DVIYLTGTLV TCRDVCHRRL IELKRPLPYD LNGKAIFHAG
     PIVRKNGDKW EMVSVGPTTS MRMESFEREF IEQTGVKLVV GKGGMGPLTE EGCQKFKALH
     VIFPAGCAVL AATQVEEIEE VHWTELGMPE SLWVCRVKEF GPLIVSIDTH GNNLIAENKK
     LFAERRDPIV EEICEHVHYI K