ID   C5131_DICDI             Reviewed;         509 AA.
AC   Q1ZXG6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Probable cytochrome P450 513A1;
DE            EC=1.14.-.-;
GN   Name=cyp513A1; ORFNames=DDB_G0282183;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AAFI02000045; EAS66871.1; -; Genomic_DNA.
DR   RefSeq; XP_001134554.1; XM_001134554.1.
DR   AlphaFoldDB; Q1ZXG6; -.
DR   SMR; Q1ZXG6; -.
DR   PaxDb; Q1ZXG6; -.
DR   EnsemblProtists; EAS66871; EAS66871; DDB_G0282183.
DR   GeneID; 8623430; -.
DR   KEGG; ddi:DDB_G0282183; -.
DR   dictyBase; DDB_G0282183; cyp513A1.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_001570_22_0_1; -.
DR   InParanoid; Q1ZXG6; -.
DR   OMA; AWDLFAR; -.
DR   PhylomeDB; Q1ZXG6; -.
DR   PRO; PR:Q1ZXG6; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..509
FT                   /note="Probable cytochrome P450 513A1"
FT                   /id="PRO_0000318813"
FT   TRANSMEM        2..19
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         454
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   509 AA;  58499 MW;  D0F08DC318467317 CRC64;
     MNYLVGLVLI FTIFYFFLQK NDKNMNSKIP GPKGIPILGN LLSMKGDLHL KLQEWYKQYG
     VIYRIKMGNV ETVVLTEYPI IREAFIGNSN SFVNRFQRKS RLKLNNGENL VIVNGDIHNK
     LKTLVLSEMT NQRIKKYETS FIDNEIKKLF KVLDEHADTG KPIILNNHIK MFSMNIVLCF
     TFGLNYSYPY DEFEKASEFI KLMVEFFNIA GQPIISDFIP SLEPFIDTSN YLNTYKRIFN
     YTSDLITKFK NENEIHNNIN DNNKSLADKP ILSKLLQSFE NGEISWDSVV STCIDLQTAG
     ADTSANTILY CLLELINNPN IQSKVYDDIK QAIIQSKENE NQNDNENQEQ TEEIITLSFN
     KYRTLAPYLS MVVKETFRKY PSGTIGLPHV TSEDVELNGY KICAGTQIIQ NIWATHRNEK
     QFSEPDSFIP ERFISQQQSA NSNLIHFGCG VRDCIGKSLA DSEIFTMLAS LINRYEFTNP
     NPSTPLNEIG KFGITYSCPE NKIIIKKRF