ID   TTDB_ECOUT              Reviewed;         201 AA.
AC   Q1R6R9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=L(+)-tartrate dehydratase subunit beta;
DE            Short=L-TTD beta;
DE            EC=4.2.1.32;
GN   Name=ttdB; OrderedLocusNames=UTI89_C3498;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R,3R)-tartrate = H2O + oxaloacetate; Xref=Rhea:RHEA:15413,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:16452, ChEBI:CHEBI:30924; EC=4.2.1.32;
CC   -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Induced by tartrate, via TtdR. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-I fumarase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000243; ABE08945.1; -; Genomic_DNA.
DR   RefSeq; WP_000722957.1; NC_007946.1.
DR   AlphaFoldDB; Q1R6R9; -.
DR   SMR; Q1R6R9; -.
DR   EnsemblBacteria; ABE08945; ABE08945; UTI89_C3498.
DR   GeneID; 67414991; -.
DR   KEGG; eci:UTI89_C3498; -.
DR   HOGENOM; CLU_098588_0_0_6; -.
DR   OMA; IYHCGPL; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0008730; F:L(+)-tartrate dehydratase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.20.130.10; -; 1.
DR   InterPro; IPR004647; Fe-S_hydro-lyase_TtdB-typ_cat.
DR   InterPro; IPR036660; Fe-S_hydroAse_TtdB_cat_sf.
DR   Pfam; PF05683; Fumerase_C; 1.
DR   SUPFAM; SSF117457; SSF117457; 1.
DR   TIGRFAMs; TIGR00723; ttdB_fumA_fumB; 1.
PE   3: Inferred from homology;
KW   Lyase.
FT   CHAIN           1..201
FT                   /note="L(+)-tartrate dehydratase subunit beta"
FT                   /id="PRO_0000262704"
FT   ACT_SITE        37
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   201 AA;  22679 MW;  E81321CD19A8BE5C CRC64;
     MKKILTTPIK AEDLQDIRVG DVIYLTGTLV TCRDVCHRRL IELKRPIPYD LNGKAIFHAG
     PIVRKNGDKW EMVSVGPTTS MRMESFEREF IEQTGVKLVV GKGGMGPLTE EGCQKFKALH
     VIFPAGCAVL AATQVEEIEE VHWTELGMPE SLWVCRVKEF GPLIVSIDTH GNNLIAENKK
     LFAERRDPIV EEICEHVHYI K