ID   TTDR_ECOL5              Reviewed;         310 AA.
AC   Q0TD46;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=HTH-type transcriptional activator TtdR;
GN   Name=ttdR; OrderedLocusNames=ECP_3150;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=536 / UPEC;
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
CC   -!- FUNCTION: Positive regulator required for L-tartrate-dependent
CC       anaerobic growth on glycerol. Induces expression of the ttdA-ttdB-ygjE
CC       operon (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; CP000247; ABG71133.1; -; Genomic_DNA.
DR   RefSeq; WP_000935209.1; NC_008253.1.
DR   AlphaFoldDB; Q0TD46; -.
DR   SMR; Q0TD46; -.
DR   STRING; 362663.ECP_3150; -.
DR   EnsemblBacteria; ABG71133; ABG71133; ECP_3150.
DR   KEGG; ecp:ECP_3150; -.
DR   HOGENOM; CLU_039613_16_4_6; -.
DR   OMA; GEIAVNW; -.
DR   Proteomes; UP000009182; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..310
FT                   /note="HTH-type transcriptional activator TtdR"
FT                   /id="PRO_0000262708"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   310 AA;  35343 MW;  17C005601F041885 CRC64;
     MLNSWPLAKD LQVLVEIVHS GSFSAAAATL GQTPAFVTKR IQILENTLAT TLLNRSARGV
     ALTESGQRCY EHALEILTQY QRLVDDVTQI KTRPEGMIRI GCSFGFGRSH IAPAITELMR
     NYPELQVHFE LFDRQIDLVQ DNIDLDIRIN DEIPDYYIAH LLTKNKRILC AAPEYLQKYP
     QPQSLQELSR HDCLVTKERD MTHGIWELGN GQEKKSVKVS GHLSSNSGEI VLQWALEGKG
     IMLRSEWDVL PFLESGKLVR VLPEYAQSAN IWAVYREPLY RSMKLRVCVE FLAAWCQQRL
     GKPDEGYQVM