ID   TTDR_ECOLI              Reviewed;         310 AA.
AC   P45463; Q2M9E5;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=HTH-type transcriptional activator TtdR;
GN   Name=ttdR; Synonyms=ygiP; OrderedLocusNames=b3060, JW3032;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-41.
RX   PubMed=3297921; DOI=10.1016/0378-1119(87)90303-9;
RA   Nesin M., Lupski J.R., Svec P., Godson G.N.;
RT   "Possible new genes as revealed by molecular analysis of a 5-kb Escherichia
RT   coli chromosomal region 5' to the rpsU-dnaG-rpoD macromolecular-synthesis
RT   operon.";
RL   Gene 51:149-161(1987).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23.
RC   STRAIN=K12;
RX   PubMed=8371115; DOI=10.1099/00221287-139-7-1523;
RA   Reaney S.K., Begg C., Bungard S.I., Guest J.R.;
RT   "Identification of the L-tartrate dehydratase genes (ttdA and ttdB) of
RT   Escherichia coli and evolutionary relationship with the class I fumarase
RT   genes.";
RL   J. Gen. Microbiol. 139:1523-1530(1993).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=7567469; DOI=10.1093/nar/23.17.3554;
RA   Borodovsky M., McIninch J., Koonin E.V., Rudd K.E., Medigue C., Danchin A.;
RT   "Detection of new genes in a bacterial genome using Markov models for three
RT   gene classes.";
RL   Nucleic Acids Res. 23:3554-3562(1995).
RN   [6]
RP   FUNCTION.
RX   PubMed=16804186; DOI=10.1099/mic.0.28753-0;
RA   Oshima T., Biville F.;
RT   "Functional identification of ygiP as a positive regulator of the ttdA-
RT   ttdB-ygjE operon.";
RL   Microbiology 152:2129-2135(2006).
CC   -!- FUNCTION: Positive regulator required for L-tartrate-dependent
CC       anaerobic growth on glycerol. Induces expression of the ttdA-ttdB-ygjE
CC       operon. {ECO:0000269|PubMed:16804186}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U28379; AAA89140.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76096.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77111.1; -; Genomic_DNA.
DR   EMBL; L14781; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   PIR; B65094; B65094.
DR   RefSeq; NP_417532.1; NC_000913.3.
DR   RefSeq; WP_000935206.1; NZ_STEB01000001.1.
DR   AlphaFoldDB; P45463; -.
DR   SMR; P45463; -.
DR   BioGRID; 4263515; 3.
DR   DIP; DIP-12223N; -.
DR   IntAct; P45463; 6.
DR   STRING; 511145.b3060; -.
DR   jPOST; P45463; -.
DR   PaxDb; P45463; -.
DR   PRIDE; P45463; -.
DR   EnsemblBacteria; AAC76096; AAC76096; b3060.
DR   EnsemblBacteria; BAE77111; BAE77111; BAE77111.
DR   GeneID; 66673041; -.
DR   GeneID; 947562; -.
DR   KEGG; ecj:JW3032; -.
DR   KEGG; eco:b3060; -.
DR   PATRIC; fig|1411691.4.peg.3671; -.
DR   EchoBASE; EB2557; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_16_4_6; -.
DR   InParanoid; P45463; -.
DR   OMA; GEIAVNW; -.
DR   PhylomeDB; P45463; -.
DR   BioCyc; EcoCyc:EG12694-MON; -.
DR   PRO; PR:P45463; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IMP:EcoliWiki.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:EcoCyc.
DR   GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..310
FT                   /note="HTH-type transcriptional activator TtdR"
FT                   /id="PRO_0000105795"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   310 AA;  35315 MW;  17C0072B72B08885 CRC64;
     MLNSWPLAKD LQVLVEIVHS GSFSAAAATL GQTPAFVTKR IQILENTLAT TLLNRSARGV
     ALTESGQRCY EHALEILTQY QRLVDDVTQI KTRPEGMIRI GCSFGFGRSH IAPAITELMR
     NYPELQVHFE LFDRQIDLVQ DNIDLDIRIN DEIPDYYIAH LLTKNKRILC AAPEYLQKYP
     QPQSLQELSR HDCLVTKERD MTHGIWELGN GQEKKSVKVS GHLSSNSGEI VLQWALEGKG
     IMLRSEWDVL PFLESGKLVQ VLPEYAQSAN IWAVYREPLY RSMKLRVCVE FLAAWCQQRL
     GKPDEGYQVM