ID   C5133_DICDI             Reviewed;         492 AA.
AC   Q55BU9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Probable cytochrome P450 513A3;
DE            EC=1.14.-.-;
GN   Name=cyp513A3; ORFNames=DDB_G0270354;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72527.1; -; Genomic_DNA.
DR   RefSeq; XP_646732.1; XM_641640.1.
DR   AlphaFoldDB; Q55BU9; -.
DR   SMR; Q55BU9; -.
DR   STRING; 44689.DDB0232338; -.
DR   PaxDb; Q55BU9; -.
DR   PRIDE; Q55BU9; -.
DR   EnsemblProtists; EAL72527; EAL72527; DDB_G0270354.
DR   GeneID; 8617704; -.
DR   KEGG; ddi:DDB_G0270354; -.
DR   dictyBase; DDB_G0270354; cyp513A3.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_001570_22_0_1; -.
DR   InParanoid; Q55BU9; -.
DR   OMA; YEMFSRL; -.
DR   PhylomeDB; Q55BU9; -.
DR   PRO; PR:Q55BU9; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..492
FT                   /note="Probable cytochrome P450 513A3"
FT                   /id="PRO_0000318814"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         437
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   492 AA;  56077 MW;  7B7270EFF7813AD7 CRC64;
     MTSLTLYLII FSIILYLFVN RNKRKNLKIP GPNGIPIFGN LLSLSGEMHL TLQEWYKTYG
     SVFSIRMGNI DTVVLTEYPT IRKAFVDNSL AFASRYQLKS RVVLTGAKDL AIQNGEIHSL
     LKKVVLSEMT TTKIKRMEIH IIKETEKILK ILDKHAERGE PFIINNYLNM FSMNVILRFL
     LGIDYPYENV DETVGYVKSI KSFFAVAGLP ILSDFIPIPL KKSGVFFDSY KELEIETDKL
     IEKFKKSRNE KIENGTYNEE EDESILSKLL KEYEHGNITW ECVSHTCIDI ISAGTDTSAN
     TLVMALIELI NNQEIQSKAF SSIRSSCLND SNDDDDDDEI VITHSKYRSL LPYISMIIKE
     TFRKHPIALL GLPHVTTEDV EIDGYKIEAG TYIIQNIFSS HRSDKIFQSP NEFIPERFFE
     SSQNQGLIHF GLGVRDCVGK SLAECEIFTL IATLLNRYQF INPNNSKKLN DIGTFGLAQV
     CPDTNIILKK RI