TTDT_ECO57
ID TTDT_ECO57 Reviewed; 487 AA.
AC Q8XBK4; Q7AAQ0;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=L-tartrate/succinate antiporter;
DE AltName: Full=Tartrate carrier;
DE AltName: Full=Tartrate transporter;
GN Name=ttdT; OrderedLocusNames=Z4416, ECs3946;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Catalyzes the uptake of tartrate in exchange for
CC intracellular succinate. Essential for anaerobic L-tartrate
CC fermentation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- INDUCTION: Induced by tartrate, via TtdR. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC DIT1 subfamily. {ECO:0000305}.
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DR EMBL; AE005174; AAG58197.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB37369.1; -; Genomic_DNA.
DR PIR; A85967; A85967.
DR PIR; B91122; B91122.
DR RefSeq; NP_311973.1; NC_002695.1.
DR RefSeq; WP_000804928.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q8XBK4; -.
DR SMR; Q8XBK4; -.
DR STRING; 155864.EDL933_4284; -.
DR EnsemblBacteria; AAG58197; AAG58197; Z4416.
DR EnsemblBacteria; BAB37369; BAB37369; ECs_3946.
DR GeneID; 916226; -.
DR KEGG; ece:Z4416; -.
DR KEGG; ecs:ECs_3946; -.
DR PATRIC; fig|386585.9.peg.4116; -.
DR eggNOG; COG0471; Bacteria.
DR HOGENOM; CLU_005170_7_0_6; -.
DR OMA; YAWHFFA; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR030676; CitT-rel.
DR InterPro; IPR001898; SLC13A/DASS.
DR PANTHER; PTHR42826; PTHR42826; 1.
DR Pfam; PF00939; Na_sulph_symp; 1.
DR PIRSF; PIRSF002457; DASS; 1.
DR TIGRFAMs; TIGR00785; dass; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..487
FT /note="L-tartrate/succinate antiporter"
FT /id="PRO_0000262711"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 487 AA; 52879 MW; 1D42EFAAA1BA21FE CRC64;
MKPSTEWWRY LAPLAVIAII ALIPVPAGLE SHTWLYFAVF TGVIVGLILE PVPGAVVAMV
GISIIAILSP WLLFSPEQLA QPGFKFTAKS LSWAVSGFSN SVIWLIFAAF MFGTGYEKTG
LGRRIALILV KKMGHRTLFL GYAVMFSELI LAPVTPSNSA RGAGIIYPII RNLPPLYQSQ
PNDSSSRSIG SYIMWMGIVA DCVTSAIFLT AMAPNLLLIG LMKSASHATL SWGDWFLGML
PLSILLVLLV PWLAYVLYPP VLKSGDQVPR WAETELQAMG PLCSREKRML GLMVGALVLW
IFGGDYIDAA MVGYSVVALM LLLRIISWDD IVSNKAAWNV FFWLASLITL ATGLNNTGFI
SWFGKLLAGS LSGYSPTMVM VALIVVFYLL RYFFASATAY TSALAPMMIA AALAMPEIPL
PVFCLMVGAA IGLGSILTPY ATGPSPIYYG SGYLPTADYW RLGAIFGLIF LVLLVITGLL
WMPVVLL
