ID   TTDT_ECOUT              Reviewed;         487 AA.
AC   Q1R6R8;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=L-tartrate/succinate antiporter;
DE   AltName: Full=Tartrate carrier;
DE   AltName: Full=Tartrate transporter;
GN   Name=ttdT; OrderedLocusNames=UTI89_C3499;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Catalyzes the uptake of tartrate in exchange for
CC       intracellular succinate. Essential for anaerobic L-tartrate
CC       fermentation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- INDUCTION: Induced by tartrate, via TtdR. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC       DIT1 subfamily. {ECO:0000305}.
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DR   EMBL; CP000243; ABE08946.1; -; Genomic_DNA.
DR   RefSeq; WP_000804955.1; NC_007946.1.
DR   AlphaFoldDB; Q1R6R8; -.
DR   SMR; Q1R6R8; -.
DR   EnsemblBacteria; ABE08946; ABE08946; UTI89_C3499.
DR   KEGG; eci:UTI89_C3499; -.
DR   HOGENOM; CLU_005170_7_0_6; -.
DR   OMA; YAWHFFA; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   InterPro; IPR030676; CitT-rel.
DR   InterPro; IPR001898; SLC13A/DASS.
DR   PANTHER; PTHR42826; PTHR42826; 1.
DR   Pfam; PF00939; Na_sulph_symp; 1.
DR   PIRSF; PIRSF002457; DASS; 1.
DR   TIGRFAMs; TIGR00785; dass; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..487
FT                   /note="L-tartrate/succinate antiporter"
FT                   /id="PRO_0000262714"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   487 AA;  52943 MW;  82CB49D925AEB2FE CRC64;
     MKPSTEWWRY LAPLAVIAII ALLPLPAGLE SHTWLYFAVF TGVIVGLILE PVPGAVVAMV
     GISIIAILSP WLLFSPEQLA QPGFKFTAKS LSWAVSGFSN SVIWLIFAAF MFGTGYEKTG
     LGRRIALILV KKMGHRTLFL GYAVMFSELI LAPVTPSNSA RGAGIIYPII RNLPPLYQSQ
     PNDSSSRSIG SYIMWMGIVA DCVTSAIFLT AMAPNLLLIG LMKSASNATL SWGDWFLGML
     PLSILLVLLV PWLAYVLYPP ILKSGDQVPR WAETELQAMG PLCSREKRML GLMVGALVLW
     IFGGDYIDAA MVGYSVVALM LLLRIICWDD IVSNKAAWNV FFWLASLITL ATGLNNTGFI
     SWFGKLLAGS LSGYSPTIVM VALIVVFYLL RYFFASATAY TSALAPMMIA AALAMPEIPL
     PVFCLMVGAA IGLGSILTPY ATGPSPIYYG SGYLPTVDYW RLGAIFGLIF LVLLVITGLL
     WMPMVLL