ID   TTDT_SHIFL              Reviewed;         487 AA.
AC   Q83JJ9; Q7BZV2;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=L-tartrate/succinate antiporter;
DE   AltName: Full=Tartrate carrier;
DE   AltName: Full=Tartrate transporter;
GN   Name=ttdT; OrderedLocusNames=SF3104, S3309;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Catalyzes the uptake of tartrate in exchange for
CC       intracellular succinate. Essential for anaerobic L-tartrate
CC       fermentation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC       DIT1 subfamily. {ECO:0000305}.
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DR   EMBL; AE005674; AAN44580.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18392.1; -; Genomic_DNA.
DR   RefSeq; NP_708873.1; NC_004337.2.
DR   RefSeq; WP_000804975.1; NZ_WPGW01000061.1.
DR   AlphaFoldDB; Q83JJ9; -.
DR   SMR; Q83JJ9; -.
DR   STRING; 198214.SF3104; -.
DR   PRIDE; Q83JJ9; -.
DR   EnsemblBacteria; AAN44580; AAN44580; SF3104.
DR   EnsemblBacteria; AAP18392; AAP18392; S3309.
DR   GeneID; 1026696; -.
DR   KEGG; sfl:SF3104; -.
DR   KEGG; sfx:S3309; -.
DR   PATRIC; fig|198214.7.peg.3683; -.
DR   HOGENOM; CLU_005170_7_0_6; -.
DR   OMA; YAWHFFA; -.
DR   OrthoDB; 626718at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   InterPro; IPR030676; CitT-rel.
DR   InterPro; IPR001898; SLC13A/DASS.
DR   PANTHER; PTHR42826; PTHR42826; 1.
DR   Pfam; PF00939; Na_sulph_symp; 1.
DR   PIRSF; PIRSF002457; DASS; 1.
DR   TIGRFAMs; TIGR00785; dass; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..487
FT                   /note="L-tartrate/succinate antiporter"
FT                   /id="PRO_0000262717"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   487 AA;  52953 MW;  46DF8429BEFF2B74 CRC64;
     MKPSTEWWRY LAPLAVIAII ALLPVPAGLE NHTWLYFAVF TGVIVGLILE PVPGAVVAMV
     GISIIAILSP WLLFSPEQLA QPGFKFTAKS LSWAVSGFSN SVIWLIFAAF MFGTGYEKTG
     LGRRIALILV KKMGHRTLFL GYAVMFSELI LAPVTPSNSA RGAGIIYPII RNLPPLYQSQ
     PNDSSSRSIG SYIMWMGIVA DCVTSAIFLT AMAPNLLLIG LMKSASHATL SWGDWFLGML
     PLSILLVLLV PWLAYVLYPP VLKSGDQVPR WAETELQAMG PLCSREKRML GLMVGALVLW
     IFGGDYIDAA MVGYSVVALM LLLRIISWDD IVSNKAAWNV FFWLASLITL ATGLNNTGFI
     SWFGKLLAGS LSGYSPTMVM VTLIVVFYLL RYFFASATAY TCALAPMMIA AALAMPEIPL
     PVFCLMVGAA IGLGSILTPY ATGPSPIYYG SGYLPTADYW RLGAIFGLIF LVLLVITGLL
     WMPVVLL