ID   TTF17_HADVE             Reviewed;          68 AA.
AC   P81803;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=U1-hexatoxin-Hv1a;
DE            Short=U1-HXTX-Hv1a;
DE   AltName: Full=Atracotoxin-Hvf17;
DE            Short=AcTx-Hvf17;
OS   Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Hexathelidae; Hadronyche.
OX   NCBI_TaxID=6904;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=10669030; DOI=10.1016/s0041-0101(99)00174-9;
RA   Szeto T.H., Wang X.-H., Smith R., Connor M., Christie M.J., Nicholson G.M.,
RA   King G.F.;
RT   "Isolation of a funnel-web spider polypeptide with homology to mamba
RT   intestinal toxin 1 and the embryonic head inducer Dickkopf-1.";
RL   Toxicon 38:429-442(2000).
RN   [2]
RP   FUNCTION.
RX   PubMed=15979762; DOI=10.1016/j.peptides.2005.05.012;
RA   Wen S., Wilson D.T., Kuruppu S., Korsinczky M.L., Hedrick J., Pang L.,
RA   Szeto T., Hodgson W.C., Alewood P.F., Nicholson G.M.;
RT   "Discovery of an MIT-like atracotoxin family: spider venom peptides that
RT   share sequence homology but not pharmacological properties with AVIT family
RT   proteins.";
RL   Peptides 26:2412-2426(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: Is not toxic to insects or mammals. Has no effect on
CC       smooth muscle contractility. Also lacks both agonist and antagonist
CC       activity at human prokineticin receptor 1 and 2 (PROKR1 and PROKR2).
CC       May not be involved in prey digestion. {ECO:0000269|PubMed:15979762}.
CC   -!- SIMILARITY: Belongs to the MIT-like AcTx family. {ECO:0000305}.
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DR   AlphaFoldDB; P81803; -.
DR   SMR; P81803; -.
DR   ArachnoServer; AS000209; U1-hexatoxin-Hv1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR020202; Atracotoxin.
DR   Pfam; PF17556; MIT_LIKE_ACTX; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..68
FT                   /note="U1-hexatoxin-Hv1a"
FT                   /evidence="ECO:0000269|PubMed:10669030"
FT                   /id="PRO_0000087670"
FT   DISULFID        3..14
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        8..22
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        13..48
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        32..56
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        50..63
FT                   /evidence="ECO:0000305|PubMed:15979762"
SQ   SEQUENCE   68 AA;  7564 MW;  E9B6C345A6E5B8CF CRC64;
     EQCGDDVCGA GHCCSEYPPM HCKRVGQLYD LCMASKATKN SGNHLFFCPC DEGMYCDMNS
     WSCQKRTA