ID   C513B_DICDI             Reviewed;         487 AA.
AC   Q54KV0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Probable cytochrome P450 513B1;
DE            EC=1.14.-.-;
GN   Name=cyp513B1; ORFNames=DDB_G0287087;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AAFI02000096; EAL63908.1; -; Genomic_DNA.
DR   RefSeq; XP_637420.1; XM_632328.1.
DR   AlphaFoldDB; Q54KV0; -.
DR   SMR; Q54KV0; -.
DR   STRING; 44689.DDB0232339; -.
DR   PaxDb; Q54KV0; -.
DR   EnsemblProtists; EAL63908; EAL63908; DDB_G0287087.
DR   GeneID; 8625952; -.
DR   KEGG; ddi:DDB_G0287087; -.
DR   dictyBase; DDB_G0287087; cyp513B1.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_001570_2_3_1; -.
DR   InParanoid; Q54KV0; -.
DR   OMA; IPNIWVM; -.
DR   PhylomeDB; Q54KV0; -.
DR   PRO; PR:Q54KV0; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..487
FT                   /note="Probable cytochrome P450 513B1"
FT                   /id="PRO_0000318815"
FT   TRANSMEM        1..18
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         433
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   487 AA;  55512 MW;  3AFA9AA88921DC52 CRC64;
     MNLLVLSVIL AIIIYLIFKR NYKYSPSKIN SKIPGPIGLP IFGNILSLDN KNGIHTTFQK
     WFKIYGPIYS VNMGNKSAVV LTGFPIIKKA FIDNSEAFAP HYTFESRYKL NKCSDITQEN
     GKNQSALKRI FLSELTVTRI KKQESHIQNE IVKLMKVLDK HSEDGKPFLL NNYFSMFSIN
     IISRFLFGID FPYQDFEETS DLMVGIRDLL IASGEIVLSD FLPIPHSKRS KLYTSYQALV
     VQIETLVKSH KYKEDDECML SKLMIEHDKG NIPWDAVISN CNTIITAGSD STSSTALFFL
     IEMMNNPTIQ TKVYNDIVVS FEQNQQADDY MNESMVILKY SKYRSLIPYL SLALKENYRK
     HPAAPFGAPH ETTQETVIEG YTIAKGTMIF QNIYATQRSD TFYSQPDEFI PERWNGDENS
     QTLISFGTGI RDCIGKSLAY NEIFTIIASV LNRYEFINPN PSIPFDDNGI PGLTTQCKNT
     VVQIKKR