ID   C513C_DICDI             Reviewed;         495 AA.
AC   Q54F47;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Probable cytochrome P450 513C1;
DE            EC=1.14.-.-;
GN   Name=cyp513C1; ORFNames=DDB_G0291105;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AAFI02000175; EAL61900.1; -; Genomic_DNA.
DR   RefSeq; XP_635407.1; XM_630315.1.
DR   AlphaFoldDB; Q54F47; -.
DR   SMR; Q54F47; -.
DR   PaxDb; Q54F47; -.
DR   EnsemblProtists; EAL61900; EAL61900; DDB_G0291105.
DR   GeneID; 8627991; -.
DR   KEGG; ddi:DDB_G0291105; -.
DR   dictyBase; DDB_G0291105; cyp513C1.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_001570_22_0_1; -.
DR   InParanoid; Q54F47; -.
DR   OMA; FTDLFCA; -.
DR   PhylomeDB; Q54F47; -.
DR   PRO; PR:Q54F47; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..495
FT                   /note="Probable cytochrome P450 513C1"
FT                   /id="PRO_0000318816"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         441
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   495 AA;  56601 MW;  AB1C1ED808DAF31D CRC64;
     MNYLVLILVS LVSIYFLFIK NQDRKKKINS KIPGPKGFLF GNLIELARTK KNLHLKYLEW
     FEKYGPVFRV SIGSLETVVL TGYPILREAF IDNSDTFTSR FQRENARSIN GYKGLINSNG
     DYHKNLKSVI LSEMTATKIK KMESHINQES KRLCELLDQH AKQGTPFTMN KYLNLFSINI
     ILRFLFGVNY PYTELDDGSS SIIQVIQQFL KLVSQPSITT YFPILSPFMN DRSKEFYDIH
     KLLSNHIINL IERYKDSKQH QQQEQEPIDG ATEPTVTILD KLLIEVENNR ITQNALISIC
     IDVLIAGTDT VGQTLSFAIV ALVNNAEIQE KLSRNIIDSM EKGDNHYSYS KYRNGIPYLA
     LVVKEVFRMY PAGILGLPHM TSEDCEIQGH KIAKGTQIIQ NIYSTHRSES FWPNPNNFIP
     ERHIQNDVSK SVHFAVGTRN CMGMSLSEAE VHTAMAELFG NFKFTNPSNI PLNDQGTFSV
     ALNCPDFFVK IERRN