ID   C513D_DICDI             Reviewed;         519 AA.
AC   Q54WB9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Probable cytochrome P450 513D1;
DE            EC=1.14.-.-;
GN   Name=cyp513D1; ORFNames=DDB_G0279763;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AAFI02000032; EAL67561.1; -; Genomic_DNA.
DR   RefSeq; XP_641539.1; XM_636447.1.
DR   AlphaFoldDB; Q54WB9; -.
DR   SMR; Q54WB9; -.
DR   STRING; 44689.DDB0232341; -.
DR   PaxDb; Q54WB9; -.
DR   EnsemblProtists; EAL67561; EAL67561; DDB_G0279763.
DR   GeneID; 8622212; -.
DR   KEGG; ddi:DDB_G0279763; -.
DR   dictyBase; DDB_G0279763; cyp513D1.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_001570_22_0_1; -.
DR   InParanoid; Q54WB9; -.
DR   OMA; FNIRLGS; -.
DR   PhylomeDB; Q54WB9; -.
DR   PRO; PR:Q54WB9; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..519
FT                   /note="Probable cytochrome P450 513D1"
FT                   /id="PRO_0000318817"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         464
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   519 AA;  59285 MW;  74FF3DAFD77CEA4A CRC64;
     MGISSIIIIL FIIVLLKKLI KKEDRIHRIN KNIPGPKSKL LVGNLFDLKG QVHEKLKEWY
     EQYGSVYRIE FGSVSTVVLT EYATLKEAFV DNGEIFQSRF QRKSRTTCNK GLNLANSNGE
     YFNHLKKTLS NEITNQKMKK NEKIIKIQVG LLSEFFNEIS GGGGGGSGGS GISKEPINNI
     IKMYSLNVML SLLFNIHFPY NNNSYQDELM STITRYFKST GLPYPSDFIP ILYPFLKNKP
     KEYFEDYESV KKLITRITNE YQLKHMTEIS NKSTIEEIEN YQPTNILESL LKQYRLNKIP
     YDGVIGCLMD LILAGSDTTG NTCLFSLVAL VNNSNIQEKL FNEISNAFND DDGDELNGAN
     DISNSLLKLS YFSDRIKTPY LVAFIKEVKR YYPCAPLSVP HLLTEDCEIQ GYKIAKGTQV
     IQNIYSTHLS QSFCSNPLEF SPERFLDSTN EPKIITFGIG QRKCPGENIF EIEIYIFLVY
     LIKKFKFSHP IDDNLQLNDR GQFGLSLQCP QLNIKVESR