ID   TTGR_PSEPK              Reviewed;         210 AA.
AC   Q88N29;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Probable HTH-type transcriptional regulator TtgR;
DE   AltName: Full=Efflux pump ttgABC operon regulator;
GN   Name=ttgR; OrderedLocusNames=PP_1387;
OS   Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950
OS   / KT2440).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=160488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440;
RX   PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA   Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA   Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA   Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA   Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M., Hance I.,
RA   Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A.,
RA   Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H.,
RA   Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C.,
RA   Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M.;
RT   "Complete genome sequence and comparative analysis of the metabolically
RT   versatile Pseudomonas putida KT2440.";
RL   Environ. Microbiol. 4:799-808(2002).
CC   -!- FUNCTION: Probable regulatory protein for the ttgABC efflux pump
CC       operon. May function as a repressor (By similarity). {ECO:0000250}.
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DR   EMBL; AE015451; AAN67010.1; -; Genomic_DNA.
DR   RefSeq; NP_743546.1; NC_002947.4.
DR   RefSeq; WP_010952495.1; NC_002947.4.
DR   AlphaFoldDB; Q88N29; -.
DR   SMR; Q88N29; -.
DR   STRING; 160488.PP_1387; -.
DR   DrugCentral; Q88N29; -.
DR   EnsemblBacteria; AAN67010; AAN67010; PP_1387.
DR   KEGG; ppu:PP_1387; -.
DR   PATRIC; fig|160488.4.peg.1471; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_12_3_6; -.
DR   OMA; MMEIIFH; -.
DR   PhylomeDB; Q88N29; -.
DR   BioCyc; PPUT160488:G1G01-1477-MON; -.
DR   Proteomes; UP000000556; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR013572; Tscrpt_reg_MAATS_C.
DR   Pfam; PF08361; TetR_C_2; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..210
FT                   /note="Probable HTH-type transcriptional regulator TtgR"
FT                   /id="PRO_0000070622"
FT   DOMAIN          10..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   210 AA;  23797 MW;  A167F57269CC2F91 CRC64;
     MVRRTKEEAQ ETRAQIIEAA ERAFYKRGVA RTTLADIAEL AGVTRGAIYW HFNNKAELVQ
     ALLDSLHETH DHLARASESE DELDPLGCMR KLLLQVFNEL VLDARTRRIN EILHHKCEFT
     DDMCEIRQQR QSAVLDCHKG ITLALANAVR RGQLPGELDV ERAAVAMFAY VDGLIGRWLL
     LPDSVDLLGD VEKWVDTGLD MLRLSPALRK