ID   TTHY_BOVIN              Reviewed;         147 AA.
AC   O46375; Q3SZ91;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Transthyretin;
DE   AltName: Full=Prealbumin;
DE   Flags: Precursor;
GN   Name=TTR;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Irikura D., Kanaoka Y., Urade Y.;
RT   "Cloning of bovine homolog of transthyretin.";
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Kidney;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH RBP4.
RX   PubMed=2598638; DOI=10.1016/0305-0491(89)90014-x;
RA   Berni R., Lamberti V.;
RT   "Dissociation of the bovine serum retinol-binding protein-transthyretin
RT   complex and purification of the two interacting proteins.";
RL   Comp. Biochem. Physiol. 94B:79-83(1989).
CC   -!- FUNCTION: Thyroid hormone-binding protein. Probably transports
CC       thyroxine from the bloodstream to the brain (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homotetramer. Dimer of dimers. In the homotetramer, subunits
CC       assemble around a central channel that can accommodate two ligand
CC       molecules. Interacts with RBP4. {ECO:0000269|PubMed:2598638}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2598638}.
CC   -!- TISSUE SPECIFICITY: Detected in serum (at protein level).
CC       {ECO:0000269|PubMed:2598638}.
CC   -!- SIMILARITY: Belongs to the transthyretin family. {ECO:0000305}.
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DR   EMBL; AB009591; BAA23983.1; -; mRNA.
DR   EMBL; BC103035; AAI03036.1; -; mRNA.
DR   RefSeq; NP_776392.1; NM_173967.3.
DR   AlphaFoldDB; O46375; -.
DR   SMR; O46375; -.
DR   STRING; 9913.ENSBTAP00000014585; -.
DR   PaxDb; O46375; -.
DR   PeptideAtlas; O46375; -.
DR   PRIDE; O46375; -.
DR   Ensembl; ENSBTAT00000014585; ENSBTAP00000014585; ENSBTAG00000010991.
DR   GeneID; 280948; -.
DR   KEGG; bta:280948; -.
DR   CTD; 7276; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010991; -.
DR   VGNC; VGNC:36499; TTR.
DR   eggNOG; KOG3006; Eukaryota.
DR   GeneTree; ENSGT00940000153229; -.
DR   HOGENOM; CLU_115536_2_0_1; -.
DR   InParanoid; O46375; -.
DR   OMA; TWEPFAT; -.
DR   OrthoDB; 1453185at2759; -.
DR   TreeFam; TF300210; -.
DR   Proteomes; UP000009136; Chromosome 24.
DR   Bgee; ENSBTAG00000010991; Expressed in liver and 94 other tissues.
DR   ExpressionAtlas; O46375; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0070324; F:thyroid hormone binding; IBA:GO_Central.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IBA:GO_Central.
DR   GO; GO:0042572; P:retinol metabolic process; IEA:InterPro.
DR   GO; GO:0070327; P:thyroid hormone transport; IEA:InterPro.
DR   Gene3D; 2.60.40.180; -; 1.
DR   InterPro; IPR023418; Thyroxine_BS.
DR   InterPro; IPR030178; Transthyretin.
DR   InterPro; IPR000895; Transthyretin/HIU_hydrolase.
DR   InterPro; IPR023416; Transthyretin/HIU_hydrolase_d.
DR   InterPro; IPR036817; Transthyretin/HIU_hydrolase_sf.
DR   InterPro; IPR023419; Transthyretin_CS.
DR   PANTHER; PTHR10395; PTHR10395; 1.
DR   PANTHER; PTHR10395:SF12; PTHR10395:SF12; 1.
DR   Pfam; PF00576; Transthyretin; 1.
DR   PRINTS; PR00189; TRNSTHYRETIN.
DR   SMART; SM00095; TR_THY; 1.
DR   SUPFAM; SSF49472; SSF49472; 1.
DR   PROSITE; PS00768; TRANSTHYRETIN_1; 1.
DR   PROSITE; PS00769; TRANSTHYRETIN_2; 1.
PE   1: Evidence at protein level;
KW   Gamma-carboxyglutamic acid; Glycoprotein; Hormone; Phosphoprotein;
KW   Reference proteome; Secreted; Signal; Thyroid hormone; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..147
FT                   /note="Transthyretin"
FT                   /id="PRO_0000035753"
FT   BINDING         35
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   BINDING         74
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   BINDING         135..139
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         62
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P02766"
FT   MOD_RES         72
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02767"
FT   CARBOHYD        118
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   147 AA;  15727 MW;  54C8CA7EC04478B7 CRC64;
     MASFRLFLLC LAGLVFVSEA GSVGAGEPKC PLMVKVLDAV RGSPAANVGV KVFKKAADET
     WEPFASGKTS ESGELHGLTT EDKFVEGLYK VELDTKSYWK SLGISPFHEF AEVVFTANDS
     GPRHYTIAAL LSPYSYSTTA LVSSPKA