ID   TTHY_MONDO              Reviewed;         149 AA.
AC   P49141;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Transthyretin;
DE   AltName: Full=Prealbumin;
DE   Flags: Precursor;
GN   Name=TTR;
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PROTEIN SEQUENCE OF 21-39, TISSUE
RP   SPECIFICITY, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Choroid plexus;
RX   PubMed=7851414; DOI=10.1111/j.1432-1033.1995.tb20402.x;
RA   Duan W., Richardson S.J., Babon J.J., Heyes R.J., Southwell B.R.,
RA   Harms P.J., Wettenhall R.E.H., Dziegielewska K.M., Selwood L.,
RA   Bradley A.J., Brack C.M., Schreiber G.;
RT   "Evolution of transthyretin in marsupials.";
RL   Eur. J. Biochem. 227:396-406(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 11-32.
RC   TISSUE=Liver;
RA   Aldred A.R.;
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Thyroid hormone-binding protein. Probably transports
CC       thyroxine from the bloodstream to the brain.
CC       {ECO:0000269|PubMed:7851414}.
CC   -!- SUBUNIT: Homotetramer. Dimer of dimers. In the homotetramer, subunits
CC       assemble around a central channel that can accommodate two ligand
CC       molecules. Interacts with RBP4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7851414}.
CC   -!- TISSUE SPECIFICITY: Detected in plasma and cerebrospinal fluid (at
CC       protein level). Highly expressed in the choroid plexus. Detected in
CC       liver. {ECO:0000269|PubMed:7851414}.
CC   -!- SIMILARITY: Belongs to the transthyretin family. {ECO:0000305}.
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DR   EMBL; U12519; AAA86053.1; -; mRNA.
DR   EMBL; X80193; CAA56476.1; -; mRNA.
DR   EMBL; Y09120; CAA70337.1; -; Genomic_DNA.
DR   EMBL; Y09121; CAA70338.1; -; Genomic_DNA.
DR   PIR; S67473; S67473.
DR   RefSeq; NP_001028140.1; NM_001032968.1.
DR   AlphaFoldDB; P49141; -.
DR   SMR; P49141; -.
DR   STRING; 13616.ENSMODP00000013682; -.
DR   Ensembl; ENSMODT00000013932; ENSMODP00000013682; ENSMODG00000010932.
DR   GeneID; 497043; -.
DR   KEGG; mdo:497043; -.
DR   CTD; 7276; -.
DR   eggNOG; KOG3006; Eukaryota.
DR   GeneTree; ENSGT00940000153229; -.
DR   HOGENOM; CLU_115536_2_0_1; -.
DR   InParanoid; P49141; -.
DR   OMA; TWEPFAT; -.
DR   OrthoDB; 1453185at2759; -.
DR   TreeFam; TF300210; -.
DR   Proteomes; UP000002280; Chromosome 3.
DR   Bgee; ENSMODG00000010932; Expressed in liver and 15 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0070324; F:thyroid hormone binding; IBA:GO_Central.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IBA:GO_Central.
DR   GO; GO:0042572; P:retinol metabolic process; IEA:InterPro.
DR   GO; GO:0070327; P:thyroid hormone transport; IEA:InterPro.
DR   Gene3D; 2.60.40.180; -; 1.
DR   InterPro; IPR023418; Thyroxine_BS.
DR   InterPro; IPR030178; Transthyretin.
DR   InterPro; IPR000895; Transthyretin/HIU_hydrolase.
DR   InterPro; IPR023416; Transthyretin/HIU_hydrolase_d.
DR   InterPro; IPR036817; Transthyretin/HIU_hydrolase_sf.
DR   InterPro; IPR023419; Transthyretin_CS.
DR   PANTHER; PTHR10395; PTHR10395; 1.
DR   PANTHER; PTHR10395:SF12; PTHR10395:SF12; 1.
DR   Pfam; PF00576; Transthyretin; 1.
DR   PRINTS; PR00189; TRNSTHYRETIN.
DR   SMART; SM00095; TR_THY; 1.
DR   SUPFAM; SSF49472; SSF49472; 1.
DR   PROSITE; PS00768; TRANSTHYRETIN_1; 1.
DR   PROSITE; PS00769; TRANSTHYRETIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Gamma-carboxyglutamic acid; Hormone;
KW   Reference proteome; Secreted; Signal; Thyroid hormone; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000269|PubMed:7851414"
FT   CHAIN           21..149
FT                   /note="Transthyretin"
FT                   /id="PRO_0000035759"
FT   BINDING         37
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   BINDING         76
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   BINDING         137..141
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         64
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P02766"
SQ   SEQUENCE   149 AA;  16418 MW;  FAC10F8001FEE485 CRC64;
     MAFHSLLLLG LASLLFVSDA APVIHGAEDS KCPLMVKVLD AVRGSPAVNV NVKVFKKSEE
     QTWEPFATGK TNDYGEIHEL TNDEKFGEGL YKVEFDTFSY WNALGVSPFH EYADVVFKAN
     DAGHRHYTIA ALLSPYSYST TAVVSNPKD