ID   TTHY_PANTR              Reviewed;         147 AA.
AC   Q5U7I5; A5A6H7; Q5IS36;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Transthyretin;
DE   AltName: Full=Prealbumin;
DE   Flags: Precursor;
GN   Name=TTR;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=11813558; DOI=10.1023/a:1013323815624;
RA   Nadezhdin E.V., Vinogradova T.V., Sverdlov E.D.;
RT   "Interspecies subtractive hybridization of cDNA from human and chimpanzee
RT   brains.";
RL   Dokl. Biochem. Biophys. 381:415-418(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cerebellum;
RX   PubMed=17574350; DOI=10.1016/j.gene.2007.04.013;
RA   Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I.,
RA   Kusuda J., Gojobori T., Hashimoto K., Hirai M.;
RT   "Mapping of chimpanzee full-length cDNAs onto the human genome unveils
RT   large potential divergence of the transcriptome.";
RL   Gene 399:1-10(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 28-147.
RX   PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA   Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA   Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT   "Accelerated evolution of nervous system genes in the origin of Homo
RT   sapiens.";
RL   Cell 119:1027-1040(2004).
CC   -!- FUNCTION: Thyroid hormone-binding protein. Probably transports
CC       thyroxine from the bloodstream to the brain (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homotetramer. Dimer of dimers. In the homotetramer, subunits
CC       assemble around a central channel that can accommodate two ligand
CC       molecules. Interacts with RBP4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Detected in brain.
CC   -!- SIMILARITY: Belongs to the transthyretin family. {ECO:0000305}.
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DR   EMBL; AY785261; AAV41026.1; -; mRNA.
DR   EMBL; AB222105; BAF62350.1; -; mRNA.
DR   EMBL; AY665292; AAV74330.1; -; mRNA.
DR   RefSeq; NP_001009137.1; NM_001009137.1.
DR   AlphaFoldDB; Q5U7I5; -.
DR   BMRB; Q5U7I5; -.
DR   SMR; Q5U7I5; -.
DR   STRING; 9598.ENSPTRP00000016916; -.
DR   PaxDb; Q5U7I5; -.
DR   Ensembl; ENSPTRT00000018264; ENSPTRP00000016916; ENSPTRG00000009949.
DR   GeneID; 493188; -.
DR   KEGG; ptr:493188; -.
DR   CTD; 7276; -.
DR   VGNC; VGNC:5217; TTR.
DR   eggNOG; KOG3006; Eukaryota.
DR   GeneTree; ENSGT00940000153229; -.
DR   InParanoid; Q5U7I5; -.
DR   OMA; TWEPFAT; -.
DR   OrthoDB; 1453185at2759; -.
DR   Proteomes; UP000002277; Chromosome 18.
DR   Bgee; ENSPTRG00000009949; Expressed in liver and 15 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0070324; F:thyroid hormone binding; IBA:GO_Central.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IBA:GO_Central.
DR   GO; GO:0042572; P:retinol metabolic process; IEA:InterPro.
DR   GO; GO:0070327; P:thyroid hormone transport; IEA:InterPro.
DR   Gene3D; 2.60.40.180; -; 1.
DR   InterPro; IPR023418; Thyroxine_BS.
DR   InterPro; IPR030178; Transthyretin.
DR   InterPro; IPR000895; Transthyretin/HIU_hydrolase.
DR   InterPro; IPR023416; Transthyretin/HIU_hydrolase_d.
DR   InterPro; IPR036817; Transthyretin/HIU_hydrolase_sf.
DR   InterPro; IPR023419; Transthyretin_CS.
DR   PANTHER; PTHR10395; PTHR10395; 1.
DR   PANTHER; PTHR10395:SF12; PTHR10395:SF12; 1.
DR   Pfam; PF00576; Transthyretin; 1.
DR   PRINTS; PR00189; TRNSTHYRETIN.
DR   SMART; SM00095; TR_THY; 1.
DR   SUPFAM; SSF49472; SSF49472; 1.
DR   PROSITE; PS00768; TRANSTHYRETIN_1; 1.
DR   PROSITE; PS00769; TRANSTHYRETIN_2; 1.
PE   2: Evidence at transcript level;
KW   Gamma-carboxyglutamic acid; Glycoprotein; Hormone; Phosphoprotein;
KW   Reference proteome; Secreted; Signal; Thyroid hormone; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..147
FT                   /note="Transthyretin"
FT                   /id="PRO_0000035761"
FT   BINDING         35
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   BINDING         74
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   BINDING         135..139
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         62
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P02766"
FT   MOD_RES         72
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02767"
FT   CARBOHYD        118
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   147 AA;  15872 MW;  F91FCC8B8B4F245C CRC64;
     MASHRLLLLC LAGLVFVSEA GPTGTGESKC PLMVKVLDAV RGSPAINVAV HVFKKAADET
     WEPFASGKTS ESGELHGLTT EEEFVEGIYK VEIDTKSYWK ALGISPFHEH AEVVFTANDS
     GPRRYTIAAL LSPYSYSTTA VVTIPKE