ID   C513F_DICDI             Reviewed;         504 AA.
AC   Q1ZXI7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Probable cytochrome P450 513F1;
DE            EC=1.14.-.-;
GN   Name=cyp513F1; ORFNames=DDB_G0278679;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AAFI02000023; EAS66900.1; -; Genomic_DNA.
DR   RefSeq; XP_001134584.1; XM_001134584.1.
DR   AlphaFoldDB; Q1ZXI7; -.
DR   SMR; Q1ZXI7; -.
DR   STRING; 44689.DDB0232343; -.
DR   PaxDb; Q1ZXI7; -.
DR   EnsemblProtists; EAS66900; EAS66900; DDB_G0278679.
DR   GeneID; 8621539; -.
DR   KEGG; ddi:DDB_G0278679; -.
DR   dictyBase; DDB_G0278679; cyp513F1.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_001570_22_0_1; -.
DR   InParanoid; Q1ZXI7; -.
DR   OMA; CAMIGFA; -.
DR   PhylomeDB; Q1ZXI7; -.
DR   PRO; PR:Q1ZXI7; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..504
FT                   /note="Probable cytochrome P450 513F1"
FT                   /id="PRO_0000318819"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         449
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   504 AA;  58197 MW;  DEA42AF031EE3AC8 CRC64;
     MILSLLFLFV ITLYFLIPSR ISKINKNIPG PIGYPIVGNL FQINKNVVKS IDGFYKEFGP
     VYRLRMGNIE TVVLTGIDTL EESFLFNKHS FVDRFVKKSR KINNGLDIIH SNGEYWKILK
     TIFQTQMTPR KIKSYQFEIQ SQVDLMAEQL YKSKNNDNIV TNINENMKFM LFNIMSILIF
     GKQSIYCNNT NNINNKDDDD VDKEKKHIIF SIGRFFKTSG SLFYSDFIPI LLPFDLINLS
     RNNFFKDFQV LTNFVSKNVN QQLSKLNDNN NNNKEKEGEE RKSIVEAYLE NYLNGEIKFE
     SVLSSCTNLL LAGTDSSANT LSFLLVSLIN NPEIQEKVYN EIITNLKNDE ISINDRFKCP
     YTCAVIKETH RLYSIAPLSE PHYCSNDVEI KGFKIAKGTQ IIQNIYSSSR SEQYWDKPLS
     FIPERFIDNA NIKEKNKNIV SFGLGLRGCI GKSFAEYMIF LTVVRLIKNY KFSNPSPNQP
     LKEIGEYGLV MNCANYNAKI EKRK