ID   TTHY_SHEEP              Reviewed;         147 AA.
AC   P12303;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Transthyretin;
DE   AltName: Full=Prealbumin;
DE   Flags: Precursor;
GN   Name=TTR;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Choroid plexus;
RX   PubMed=2771647; DOI=10.1093/nar/17.15.6384;
RA   Tu G., Cole T., Duan W., Schreiber G.;
RT   "The nucleotide sequence of transthyretin cDNA isolated from a sheep
RT   choroid plexus cDNA library.";
RL   Nucleic Acids Res. 17:6384-6384(1989).
CC   -!- FUNCTION: Thyroid hormone-binding protein. Probably transports
CC       thyroxine from the bloodstream to the brain (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homotetramer. Dimer of dimers. In the homotetramer, subunits
CC       assemble around a central channel that can accommodate two ligand
CC       molecules. Interacts with RBP4 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the choroid plexus.
CC   -!- SIMILARITY: Belongs to the transthyretin family. {ECO:0000305}.
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DR   EMBL; X15576; CAA33600.1; -; mRNA.
DR   PIR; S05320; S05320.
DR   RefSeq; NP_001009800.1; NM_001009800.1.
DR   AlphaFoldDB; P12303; -.
DR   SMR; P12303; -.
DR   STRING; 9940.ENSOARP00000006793; -.
DR   PRIDE; P12303; -.
DR   Ensembl; ENSOART00000006897; ENSOARP00000006793; ENSOARG00000006342.
DR   Ensembl; ENSOART00020038943; ENSOARP00020032265; ENSOARG00020024865.
DR   GeneID; 443389; -.
DR   KEGG; oas:443389; -.
DR   CTD; 7276; -.
DR   eggNOG; KOG3006; Eukaryota.
DR   HOGENOM; CLU_115536_2_0_1; -.
DR   OMA; TWEPFAT; -.
DR   OrthoDB; 1453185at2759; -.
DR   Proteomes; UP000002356; Chromosome 23.
DR   Bgee; ENSOARG00000006342; Expressed in embryo and 30 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0070324; F:thyroid hormone binding; IEA:InterPro.
DR   GO; GO:0042572; P:retinol metabolic process; IEA:InterPro.
DR   GO; GO:0070327; P:thyroid hormone transport; IEA:InterPro.
DR   Gene3D; 2.60.40.180; -; 1.
DR   InterPro; IPR023418; Thyroxine_BS.
DR   InterPro; IPR030178; Transthyretin.
DR   InterPro; IPR000895; Transthyretin/HIU_hydrolase.
DR   InterPro; IPR023416; Transthyretin/HIU_hydrolase_d.
DR   InterPro; IPR036817; Transthyretin/HIU_hydrolase_sf.
DR   InterPro; IPR023419; Transthyretin_CS.
DR   PANTHER; PTHR10395; PTHR10395; 1.
DR   PANTHER; PTHR10395:SF12; PTHR10395:SF12; 1.
DR   Pfam; PF00576; Transthyretin; 1.
DR   PRINTS; PR00189; TRNSTHYRETIN.
DR   SMART; SM00095; TR_THY; 1.
DR   SUPFAM; SSF49472; SSF49472; 1.
DR   PROSITE; PS00768; TRANSTHYRETIN_1; 1.
DR   PROSITE; PS00769; TRANSTHYRETIN_2; 1.
PE   2: Evidence at transcript level;
KW   Gamma-carboxyglutamic acid; Glycoprotein; Hormone; Phosphoprotein;
KW   Reference proteome; Secreted; Signal; Thyroid hormone; Transport.
FT   SIGNAL          1..20
FT   CHAIN           21..147
FT                   /note="Transthyretin"
FT                   /id="PRO_0000035765"
FT   BINDING         35
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   BINDING         74
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   BINDING         135..139
FT                   /ligand="L-thyroxine"
FT                   /ligand_id="ChEBI:CHEBI:58448"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         62
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P02766"
FT   MOD_RES         72
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02767"
FT   CARBOHYD        118
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   147 AA;  15771 MW;  867D69DD610E23ED CRC64;
     MASFRLLLLC LAGLVFVSEA SPAGAGESKC PLMVKVLDAV RGSPAANVGV KVFKKAADET
     WEPFASGKTS DSGELHGLTT EDKFVEGLYK VELDTKSYWK SLGISPFHEY AEVVFTANDS
     GLRHYTIAAL LSPYSYSTTA LVSSPKE