ID   TTI1_SCHPO              Reviewed;        1098 AA.
AC   O94600;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=TEL2-interacting protein 1;
GN   Name=tti1; ORFNames=SPCC622.13c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   IDENTIFICATION IN THE TORC1 AND TORC2 COMPLEXES, INTERACTION WITH TEL2, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18076573; DOI=10.1111/j.1365-2443.2007.01141.x;
RA   Hayashi T., Hatanaka M., Nagao K., Nakaseko Y., Kanoh J., Kokubu A.,
RA   Ebe M., Yanagida M.;
RT   "Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and
RT   organization of two highly phosphorylated TOR complexes by specific and
RT   common subunits.";
RL   Genes Cells 12:1357-1370(2007).
CC   -!- FUNCTION: Component of the TORC1 and TORC2 complexes required for the
CC       regulation of the cellular respons to changes in available nutrients.
CC   -!- SUBUNIT: Component of the TORC1 complex composed of at least mip1,
CC       orb5, tel2, toc1, toc89, tor2, tti1 and wat1. Component of the TORC2
CC       complex composed of at least bit61, orb5, sin1, ste20, tel2, tor1, tti1
CC       and wat1. Interacts with tel2. {ECO:0000269|PubMed:18076573}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tti1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329672; CAA21869.1; -; Genomic_DNA.
DR   PIR; T41493; T41493.
DR   RefSeq; NP_588185.1; NM_001023175.2.
DR   AlphaFoldDB; O94600; -.
DR   BioGRID; 276043; 6.
DR   IntAct; O94600; 4.
DR   MINT; O94600; -.
DR   STRING; 4896.SPCC622.13c.1; -.
DR   iPTMnet; O94600; -.
DR   MaxQB; O94600; -.
DR   PaxDb; O94600; -.
DR   PRIDE; O94600; -.
DR   EnsemblFungi; SPCC622.13c.1; SPCC622.13c.1:pep; SPCC622.13c.
DR   GeneID; 2539480; -.
DR   KEGG; spo:SPCC622.13c; -.
DR   PomBase; SPCC622.13c; tti1.
DR   VEuPathDB; FungiDB:SPCC622.13c; -.
DR   eggNOG; KOG4524; Eukaryota.
DR   HOGENOM; CLU_005544_0_0_1; -.
DR   InParanoid; O94600; -.
DR   OMA; GAHTCQV; -.
DR   PhylomeDB; O94600; -.
DR   PRO; PR:O94600; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0070209; C:ASTRA complex; IDA:PomBase.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0110078; C:TTT complex; IDA:PomBase.
DR   GO; GO:0006338; P:chromatin remodeling; IPI:PomBase.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR016441; Tti1.
DR   PIRSF; PIRSF005250; UCP005250; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..1098
FT                   /note="TEL2-interacting protein 1"
FT                   /id="PRO_0000353822"
FT   REGION          768..795
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1098 AA;  124765 MW;  7F77BB2666EC0F94 CRC64;
     MSHIQSIFAQ IRDPFRKLSF YSLPLSSETS SVDSNGLKNS LKDAYFGLEK ALTNTDADLP
     LNLCDYIFFP IVPVLKSWYR VPSTGVEYAI QCVNLLYKHG WREAHNEMLT MQLLLMLLNI
     ADGWKSPSET VEQDFRVREI TFETLENVIT DFKPNFHDKR QYLLFARALS SALDIIPNKN
     SSRRLQFASL CCVQKLICPK QYRLPTEFLT TFLPGIVSGL TKGLAPNGTC QYFKNVCISL
     NILGDTVVKA ISDDNTKDLP DEKDASSNSH FFGPTKRTKS WKRATCQQLS NAVKAILHLR
     SSQNLHVQDA LFDFCFILFR DCLDSLKDCR IHLLESMLKL INKKENPKLR DYGMNKLVSL
     IESFNNITME SVLTECLNDW STTWSSVSTF ASEDNKLEEL NRLKSLLSIS SHLPKTLQLM
     EPLLDGILSQ LVPKSSGIDS NSQKLLTSST SNEYIHGEFF GGNEMERTTQ EIVTSFAKAP
     NVKYVMQSLL SKATSATNEN SVRAFWAFMV LLKSDVETVD SLEMYIDSLE QYSFEVLQQL
     SQLNVFTKAS LEDKQKKEKY NLLCVRSCIA IDSISWISSL QGVKFRSKLM AYFYPLLEHL
     AFASPYVSSF AEACIQAIAT NCNYSTPAEL LRENIDYVVN SVALKLNTLD VSPQLPIVMA
     YVIKNDDGGC IRYIGDVVDA IFGILDAYHG YARLTEGLLG ILYAIIKQES INGEEKKLIV
     GVEEDAMNED KNKPCKKIRE FVQLLLENPN YPLPKDDHEL EDMIHDEQQE TKSGHEQFRE
     HAMKEKEKKG KENENMGETT VDHENINSNV MDEQGEKQKD DVVDMVRKIT EKAQLFLSHE
     QITIRVEMLK LLSYGSNVLA KEPNTFYPAI NTFWPLVVIQ LDTDNELLVE CALETIYQVC
     ALADDFMTSR IRQDLLPRLE TLCQRWHLFN VARTYSSEHR LQRAMLKVTS ACVANKLSIV
     VYLKLMGITA PIIRAITHMS QKYAGDESLV EETWNAFSKQ NPDAVYYERE VRGSQMIDTF
     STELLIPGKQ RVQRTYRRTH EVLEPVGAKT SETVFNDLLG QQGSGKTETQ EEPLPSLDNL
     LHLNQPKKGA KKPLISII