ID   TTI2_RAT                Reviewed;         511 AA.
AC   Q66H56;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=TELO2-interacting protein 2;
GN   Name=Tti2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT
CC       complex that is required to stabilize protein levels of the
CC       phosphatidylinositol 3-kinase-related protein kinase (PIKK) family
CC       proteins. The TTT complex is involved in the cellular resistance to DNA
CC       damage stresses, like ionizing radiation (IR), ultraviolet (UV) and
CC       mitomycin C (MMC). Together with the TTT complex and HSP90 may
CC       participate in the proper folding of newly synthesized PIKKs (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the TTT complex composed of TELO2, TTI1 and TTI2.
CC       Interacts with TELO2 and TTI1. Interacts with WAC; WAC positively
CC       regulates MTOR activity by promoting the assembly of the TTT complex
CC       and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL
CC       complex which leads to the dimerization of the mTORC1 complex and its
CC       subsequent activation. {ECO:0000250|UniProtKB:Q6NXR4}.
CC   -!- SIMILARITY: Belongs to the TTI2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC082008; AAH82008.1; -; mRNA.
DR   RefSeq; NP_001013905.1; NM_001013883.1.
DR   AlphaFoldDB; Q66H56; -.
DR   SMR; Q66H56; -.
DR   STRING; 10116.ENSRNOP00000028965; -.
DR   PhosphoSitePlus; Q66H56; -.
DR   jPOST; Q66H56; -.
DR   PaxDb; Q66H56; -.
DR   Ensembl; ENSRNOT00000032467; ENSRNOP00000028965; ENSRNOG00000023494.
DR   GeneID; 290811; -.
DR   KEGG; rno:290811; -.
DR   UCSC; RGD:1310414; rat.
DR   CTD; 80185; -.
DR   RGD; 1310414; Tti2.
DR   eggNOG; ENOG502QVMM; Eukaryota.
DR   GeneTree; ENSGT00390000003878; -.
DR   HOGENOM; CLU_047507_0_0_1; -.
DR   InParanoid; Q66H56; -.
DR   OMA; WDVHTDQ; -.
DR   OrthoDB; 1298755at2759; -.
DR   PhylomeDB; Q66H56; -.
DR   TreeFam; TF328871; -.
DR   PRO; PR:Q66H56; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000023494; Expressed in thymus and 20 other tissues.
DR   ExpressionAtlas; Q66H56; baseline and differential.
DR   Genevisible; Q66H56; RN.
DR   GO; GO:0070209; C:ASTRA complex; IBA:GO_Central.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0110078; C:TTT complex; ISO:RGD.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR018870; Tti2.
DR   PANTHER; PTHR32226; PTHR32226; 1.
DR   Pfam; PF10521; Tti2; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..511
FT                   /note="TELO2-interacting protein 2"
FT                   /id="PRO_0000279416"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  56436 MW;  81DDD9EA5ACD1B72 CRC64;
     MKLGSTEEKS GGGCSLPTEV SPPALQQAFS KILHGLSRQE SSGQGNAGNA ALRDLGALIE
     ATECDKLFEG TGGGGSPREM PEILGQVAKA LEKFAAPKEK ADGSEEHPEV PEKATEVGLL
     FLKLLGKVET AKSSPVCPAW KTGLRHLSGP TYIFAITHRL KQPWTSPKSQ HVAGEVLSLL
     FRVTECSSVA EFLCGENKDD RGRFAVVLGL LKPHLNKETW KKNPAVKHVF SWTLQQVTQP
     WLSQHLEKIL PPSLLISDDY QTDNKVLGVQ CLHHIVINVP AADLLQYNRA QVLYHALFNH
     LYMPEHRLIQ AVLLCLLDLF PVLEKALHWQ GEAARASTHC HEVLQLVLTH MESEHRLLLR
     RTYARNLPAF VKKLGILTAR HLKRLEQVIL GYLEVYDEPE DESRLKILET LKLVMQYTWP
     RIPCRVVVLL KALLKLICDI ARDTIPTTEA AKSAVLQEAT DCLILLDHCS QGQVKGLLAN
     IALSCDDSTV VSCIRKVQGS AEAPGEDPGD D