TTL2_ARATH
ID TTL2_ARATH Reviewed; 730 AA.
AC F4IXE4; Q9LKB0;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 2.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=TPR repeat-containing thioredoxin TTL2;
DE AltName: Full=Tetratricopeptide repeat thioredoxin-like 2;
GN Name=TTL2; OrderedLocusNames=At3g14950; ORFNames=K15M2.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=16998088; DOI=10.1104/pp.106.085191;
RA Rosado A., Schapire A.L., Bressan R.A., Harfouche A.L., Hasegawa P.M.,
RA Valpuesta V., Botella M.A.;
RT "The Arabidopsis tetratricopeptide repeat-containing protein TTL1 is
RT required for osmotic stress responses and abscisic acid sensitivity.";
RL Plant Physiol. 142:1113-1126(2006).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22232384; DOI=10.1104/pp.111.188920;
RA Lakhssassi N., Doblas V.G., Rosado A., Esteban Del Valle A., Pose D.,
RA Jimenez A.J., Castillo A.G., Valpuesta V., Borsani O., Botella M.A.;
RT "The Arabidopsis thaliana TETRATRICO PEPTIDE THIOREDOXIN-LIKE gene family
RT is required for osmotic stress tolerance and male sporogenesis.";
RL Plant Physiol. 158:1252-1266(2012).
CC -!- FUNCTION: Plays a role in the transmission of male gametophyte.
CC {ECO:0000269|PubMed:22232384}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in pollen grains.
CC {ECO:0000269|PubMed:22232384}.
CC -!- INDUCTION: Not induced by salt treatment.
CC {ECO:0000269|PubMed:22232384}.
CC -!- DISRUPTION PHENOTYPE: Decreased efficiency of the male gametophyte
CC transmission and reduced fertility. {ECO:0000269|PubMed:22232384}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA97058.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP000370; BAA97058.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE75593.2; -; Genomic_DNA.
DR RefSeq; NP_001319556.1; NM_001338142.1.
DR AlphaFoldDB; F4IXE4; -.
DR SMR; F4IXE4; -.
DR STRING; 3702.AT3G14950.1; -.
DR PaxDb; F4IXE4; -.
DR PRIDE; F4IXE4; -.
DR ProteomicsDB; 234604; -.
DR EnsemblPlants; AT3G14950.1; AT3G14950.1; AT3G14950.
DR GeneID; 820724; -.
DR Gramene; AT3G14950.1; AT3G14950.1; AT3G14950.
DR KEGG; ath:AT3G14950; -.
DR Araport; AT3G14950; -.
DR eggNOG; KOG0907; Eukaryota.
DR eggNOG; KOG1124; Eukaryota.
DR HOGENOM; CLU_015299_0_0_1; -.
DR InParanoid; F4IXE4; -.
DR OMA; DKHLNKC; -.
DR OrthoDB; 506649at2759; -.
DR PRO; PR:F4IXE4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4IXE4; baseline and differential.
DR Genevisible; F4IXE4; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR044534; TTL1-4.
DR PANTHER; PTHR46050; PTHR46050; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..730
FT /note="TPR repeat-containing thioredoxin TTL2"
FT /id="PRO_0000415943"
FT REPEAT 258..291
FT /note="TPR 1"
FT REPEAT 293..325
FT /note="TPR 2"
FT REPEAT 327..359
FT /note="TPR 3"
FT REPEAT 448..483
FT /note="TPR 4"
FT REPEAT 496..529
FT /note="TPR 5"
FT REPEAT 531..563
FT /note="TPR 6"
FT REPEAT 565..600
FT /note="TPR 7"
FT DOMAIN 636..722
FT /note="Thioredoxin"
FT REGION 23..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 79754 MW; 74CCB098EEC2E14F CRC64;
MSKLKKPILE SNCVADKLCD SLNMEDNNND KPDTINVDLG SPITPLQTQP SGLSSSTSSF
SSSSSGSVTG HAGHTPPVTR KPDSVQPVPS ASKSKSSNLS SAAKSSKSST TPSSAAQFGG
SYSPARAQSR ASSQVGAKTG NIIRPSSNSA SVTTKPSGNK SSVSSKQSLK ILPAGNLVPS
GKVQITGMTQ EKPRSMVLGP GAKSYGYGSI IRGNNLSPVK PTMMSDSSSV LPLTLSNNST
GGPDAYTSWK IAIYGSNPEE VKRFGNEMFR KGCFAEALKL YDRAIELSPS NATYHSNRAA
ALSSLGQIGE AVNECEIAIK LDPNFARAHH RLASLLLRLG YVDNAGIHLY SVEEPLDPTV
VKMLQQVDKH LNKCTYARRR GEWSIVLTEV SAAIASGADS SPQLAMCKAE ALLKLLRLDD
AQRVLECVPK VEPFPASFSH TRFFDMIAEA YTSFVKSQME LALGRFENAV VTAEKASKID
PQNNEVEILY KNVRLITRAR DRGNDLYELE RYTEARSAYA EGLKYDPSNA TLLCYRADCF
FKVGMWESSI EDCNHALLIL PSYTKPRLQR AALYTKLERW AEAVSDYEIL RKELPYDKEI
AESLFHAQVA LKKSRGEVVL NMEFGGEVEE ISSLEELKAA LTRPGVSVVH FFRASDPQCK
EISTFVDALC VRYPSLHFLK VEIVKCPEVG NAERVRVVPT FKIYKLGIRM KEIVCPSKEA
LEKTVRHYGL
