TTL4_ARATH
ID TTL4_ARATH Reviewed; 682 AA.
AC Q84JR9; Q9M2F5;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=TPR repeat-containing thioredoxin TTL4;
DE AltName: Full=Tetratricopeptide repeat thioredoxin-like 4;
GN Name=TTL4; OrderedLocusNames=At3g58620; ORFNames=F14P22.210;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=16998088; DOI=10.1104/pp.106.085191;
RA Rosado A., Schapire A.L., Bressan R.A., Harfouche A.L., Hasegawa P.M.,
RA Valpuesta V., Botella M.A.;
RT "The Arabidopsis tetratricopeptide repeat-containing protein TTL1 is
RT required for osmotic stress responses and abscisic acid sensitivity.";
RL Plant Physiol. 142:1113-1126(2006).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22232384; DOI=10.1104/pp.111.188920;
RA Lakhssassi N., Doblas V.G., Rosado A., Esteban Del Valle A., Pose D.,
RA Jimenez A.J., Castillo A.G., Valpuesta V., Borsani O., Botella M.A.;
RT "The Arabidopsis thaliana TETRATRICO PEPTIDE THIOREDOXIN-LIKE gene family
RT is required for osmotic stress tolerance and male sporogenesis.";
RL Plant Physiol. 158:1252-1266(2012).
CC -!- FUNCTION: Involved in osmotic and salt stress tolerance. May play a
CC role in the control of meristematic cell size during osmotic stress.
CC {ECO:0000269|PubMed:22232384}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:22232384}.
CC -!- INDUCTION: By salt treatment in cotyledons.
CC {ECO:0000269|PubMed:22232384}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant seedlings display increased tolerance to salt
CC stress at moderate NaCl concentrations (120 mM).
CC {ECO:0000269|PubMed:22232384}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB68200.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL137082; CAB68200.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE79807.1; -; Genomic_DNA.
DR EMBL; BT003919; AAO41966.1; -; mRNA.
DR EMBL; BT005006; AAO50539.1; -; mRNA.
DR PIR; T45682; T45682.
DR RefSeq; NP_191421.2; NM_115724.4.
DR AlphaFoldDB; Q84JR9; -.
DR SMR; Q84JR9; -.
DR STRING; 3702.AT3G58620.1; -.
DR iPTMnet; Q84JR9; -.
DR PaxDb; Q84JR9; -.
DR PRIDE; Q84JR9; -.
DR ProteomicsDB; 232368; -.
DR EnsemblPlants; AT3G58620.1; AT3G58620.1; AT3G58620.
DR GeneID; 825031; -.
DR Gramene; AT3G58620.1; AT3G58620.1; AT3G58620.
DR KEGG; ath:AT3G58620; -.
DR Araport; AT3G58620; -.
DR TAIR; locus:2076386; AT3G58620.
DR eggNOG; KOG0907; Eukaryota.
DR eggNOG; KOG1124; Eukaryota.
DR HOGENOM; CLU_015299_0_0_1; -.
DR InParanoid; Q84JR9; -.
DR OrthoDB; 506649at2759; -.
DR PhylomeDB; Q84JR9; -.
DR PRO; PR:Q84JR9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q84JR9; baseline and differential.
DR Genevisible; Q84JR9; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0006970; P:response to osmotic stress; IMP:TAIR.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR044534; TTL1-4.
DR PANTHER; PTHR46050; PTHR46050; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13174; TPR_6; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Repeat; Stress response; TPR repeat.
FT CHAIN 1..682
FT /note="TPR repeat-containing thioredoxin TTL4"
FT /id="PRO_0000415945"
FT REPEAT 211..244
FT /note="TPR 1"
FT REPEAT 246..278
FT /note="TPR 2"
FT REPEAT 280..312
FT /note="TPR 3"
FT REPEAT 402..435
FT /note="TPR 4"
FT REPEAT 449..482
FT /note="TPR 5"
FT REPEAT 483..516
FT /note="TPR 6"
FT REPEAT 518..550
FT /note="TPR 7"
FT DOMAIN 587..674
FT /note="Thioredoxin"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9SIN1"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9SIN1"
SQ SEQUENCE 682 AA; 74387 MW; 75DF0DBE90F40F41 CRC64;
MSHYRRHSLE PSITSKFRDS LSFQRDDDVI NKPDFRELDF GSPLRPRGSS SAAATPAASG
SSSSSSGSAS GKPAVTSQFA RRSHSGELSG LSQTSPVKPG SVNRNLKPGH RRSASAGTPL
IYSGLGFSPV NNNNNSSRGG GSGATSPNPG VLPTGNICPS GRILKTGMAT RASVRPETLC
TGTANYGHGN IIRTGGKVSH ATKAAAEMSD SEEVKKAGNV MYRKGNYAEA LALYDRAISL
SPENPAYRSN RAAALAASGR LEEAVKECLE AVRCDPSYAR AHQRLASLYL RLGEAENARR
HLCVSGQCPD QADLQRLQTL EKHLRLCTEA RKIGDWRTVI SEIDAAIANG ADSSPQLVAC
KAEAFLRLHQ IKDSDLCISS IPRLDHHHTQ PPEKLFGIVC DAYVLCVQAQ VDMALGRFEN
AIVKVERAMT IDHSNSPEVV SVLNNVKNVA KARTRGNELF SSGRYSEASV AYGDGLKLDA
FNSVLYCNRA ACWFKLGMWE KSVDDCNQAL RIQPSYTKAL LRRAASYGKL GRWEDAVRDY
EVLRKELPGD SEVAESLQRA RNALSNKSEE PKYLGFNNEV EEVSTLDKFK TATSLPGISV
FHFKSSSNRQ SEAISPFVNT LCLRYPLVHF FKVDVEESLA LAKAESIKKI PTFKIYKKGE
KVKEMVCPSH QLLEDSVTHF LL
