TTMP_HUMAN
ID TTMP_HUMAN Reviewed; 217 AA.
AC Q5BVD1; B4DNV2; B4E0Z2; Q96AJ4; Q9H5Q1;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=TPA-induced transmembrane protein;
GN Name=TTMP; Synonyms=C3orf52;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, AND VARIANT SER-144.
RC TISSUE=Colon;
RX PubMed=15737651; DOI=10.1016/j.bbrc.2005.02.037;
RA Chan C.-Y., Salabat M.R., Ding X.-Z., Kelly D.L., Talamonti M.S.,
RA Bell R.H. Jr., Adrian T.E.;
RT "Identification and in silico characterization of a novel gene: TPA induced
RT trans-membrane protein.";
RL Biochem. Biophys. Res. Commun. 329:755-764(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 11-217 (ISOFORM 3), AND VARIANT SER-144.
RC TISSUE=Lung, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-144.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5BVD1; Q86Y34: ADGRG3; NbExp=3; IntAct=EBI-10243654, EBI-17979264;
CC Q5BVD1; Q15109: AGER; NbExp=3; IntAct=EBI-10243654, EBI-1646426;
CC Q5BVD1; Q8IVF2-3: AHNAK2; NbExp=3; IntAct=EBI-10243654, EBI-12078468;
CC Q5BVD1; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-10243654, EBI-19125216;
CC Q5BVD1; Q13520: AQP6; NbExp=3; IntAct=EBI-10243654, EBI-13059134;
CC Q5BVD1; Q9UN42: ATP1B4; NbExp=3; IntAct=EBI-10243654, EBI-12894731;
CC Q5BVD1; Q13323: BIK; NbExp=3; IntAct=EBI-10243654, EBI-700794;
CC Q5BVD1; O00585: CCL21; NbExp=3; IntAct=EBI-10243654, EBI-953695;
CC Q5BVD1; Q9Y258: CCL26; NbExp=3; IntAct=EBI-10243654, EBI-7783416;
CC Q5BVD1; P20138: CD33; NbExp=3; IntAct=EBI-10243654, EBI-3906571;
CC Q5BVD1; Q8NET6: CHST13; NbExp=3; IntAct=EBI-10243654, EBI-11599701;
CC Q5BVD1; O95471: CLDN7; NbExp=3; IntAct=EBI-10243654, EBI-740744;
CC Q5BVD1; Q8IUN9: CLEC10A; NbExp=3; IntAct=EBI-10243654, EBI-2873246;
CC Q5BVD1; O75829-2: CNMD; NbExp=3; IntAct=EBI-10243654, EBI-10696063;
CC Q5BVD1; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-10243654, EBI-18013275;
CC Q5BVD1; O95424: DEXI; NbExp=3; IntAct=EBI-10243654, EBI-724515;
CC Q5BVD1; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10243654, EBI-781551;
CC Q5BVD1; P30040: ERP29; NbExp=3; IntAct=EBI-10243654, EBI-946830;
CC Q5BVD1; Q96AP7: ESAM; NbExp=3; IntAct=EBI-10243654, EBI-4314670;
CC Q5BVD1; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10243654, EBI-18304435;
CC Q5BVD1; O15552: FFAR2; NbExp=3; IntAct=EBI-10243654, EBI-2833872;
CC Q5BVD1; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-10243654, EBI-12142257;
CC Q5BVD1; Q04609-8: FOLH1; NbExp=3; IntAct=EBI-10243654, EBI-13060980;
CC Q5BVD1; P21217: FUT3; NbExp=3; IntAct=EBI-10243654, EBI-12839380;
CC Q5BVD1; P48165: GJA8; NbExp=3; IntAct=EBI-10243654, EBI-17458373;
CC Q5BVD1; P08034: GJB1; NbExp=3; IntAct=EBI-10243654, EBI-17565645;
CC Q5BVD1; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-10243654, EBI-3917143;
CC Q5BVD1; Q9UM44: HHLA2; NbExp=3; IntAct=EBI-10243654, EBI-2867874;
CC Q5BVD1; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-10243654, EBI-18053395;
CC Q5BVD1; P23276: KEL; NbExp=3; IntAct=EBI-10243654, EBI-746662;
CC Q5BVD1; P43628: KIR2DL3; NbExp=3; IntAct=EBI-10243654, EBI-8632435;
CC Q5BVD1; P26715: KLRC1; NbExp=3; IntAct=EBI-10243654, EBI-9018187;
CC Q5BVD1; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-10243654, EBI-17490413;
CC Q5BVD1; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-10243654, EBI-2820517;
CC Q5BVD1; Q8N386: LRRC25; NbExp=3; IntAct=EBI-10243654, EBI-11304917;
CC Q5BVD1; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-10243654, EBI-11956541;
CC Q5BVD1; Q99735: MGST2; NbExp=3; IntAct=EBI-10243654, EBI-11324706;
CC Q5BVD1; O14880: MGST3; NbExp=3; IntAct=EBI-10243654, EBI-724754;
CC Q5BVD1; Q96LB0: MRGPRX3; NbExp=3; IntAct=EBI-10243654, EBI-17958655;
CC Q5BVD1; P15941-11: MUC1; NbExp=3; IntAct=EBI-10243654, EBI-17263240;
CC Q5BVD1; Q68D85: NCR3LG1; NbExp=3; IntAct=EBI-10243654, EBI-14061804;
CC Q5BVD1; O14524-2: NEMP1; NbExp=3; IntAct=EBI-10243654, EBI-10969203;
CC Q5BVD1; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-10243654, EBI-748927;
CC Q5BVD1; Q9Y328: NSG2; NbExp=3; IntAct=EBI-10243654, EBI-7101695;
CC Q5BVD1; P15151: PVR; NbExp=3; IntAct=EBI-10243654, EBI-3919694;
CC Q5BVD1; Q9NXS2-3: QPCTL; NbExp=3; IntAct=EBI-10243654, EBI-13336719;
CC Q5BVD1; Q6NUK4: REEP3; NbExp=3; IntAct=EBI-10243654, EBI-7545786;
CC Q5BVD1; Q9ULK6-3: RNF150; NbExp=3; IntAct=EBI-10243654, EBI-23640835;
CC Q5BVD1; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-10243654, EBI-3920694;
CC Q5BVD1; O43765: SGTA; NbExp=6; IntAct=EBI-10243654, EBI-347996;
CC Q5BVD1; Q8N7X8: SIGLECL1; NbExp=3; IntAct=EBI-10243654, EBI-18052611;
CC Q5BVD1; Q12908: SLC10A2; NbExp=3; IntAct=EBI-10243654, EBI-18114847;
CC Q5BVD1; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-10243654, EBI-12898013;
CC Q5BVD1; Q9H741: SPRING1; NbExp=3; IntAct=EBI-10243654, EBI-2836158;
CC Q5BVD1; Q8NDV1: ST6GALNAC3; NbExp=3; IntAct=EBI-10243654, EBI-12947081;
CC Q5BVD1; P27105: STOM; NbExp=3; IntAct=EBI-10243654, EBI-1211440;
CC Q5BVD1; Q8N205: SYNE4; NbExp=3; IntAct=EBI-10243654, EBI-7131783;
CC Q5BVD1; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-10243654, EBI-6268651;
CC Q5BVD1; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-10243654, EBI-11724423;
CC Q5BVD1; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-10243654, EBI-10982110;
CC Q5BVD1; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-10243654, EBI-3923061;
CC Q5BVD1; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-10243654, EBI-18178701;
CC Q5BVD1; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-10243654, EBI-11742770;
CC Q5BVD1; O15393-2: TMPRSS2; NbExp=5; IntAct=EBI-10243654, EBI-12345267;
CC Q5BVD1; Q9Y320: TMX2; NbExp=3; IntAct=EBI-10243654, EBI-6447886;
CC Q5BVD1; O00526: UPK2; NbExp=3; IntAct=EBI-10243654, EBI-10179682;
CC Q5BVD1; Q9ULT6: ZNRF3; NbExp=3; IntAct=EBI-10243654, EBI-949772;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Single-pass type I membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5BVD1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5BVD1-2; Sequence=VSP_036120;
CC Name=3;
CC IsoId=Q5BVD1-3; Sequence=VSP_036121;
CC -!- INDUCTION: Up-regulated following treatment with 12-O-
CC tetradecanoylphorbol-13-acetate (TPA) in the pancreatic cancer cell
CC line HPAF-II. The up-regulation by TPA is triggered at the promoter
CC level. {ECO:0000269|PubMed:15737651}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH17064.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB15569.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAG60364.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY830714; AAX21411.1; -; mRNA.
DR EMBL; AK026839; BAB15569.1; ALT_FRAME; mRNA.
DR EMBL; AK298076; BAG60364.1; ALT_INIT; mRNA.
DR EMBL; AK303588; BAG64604.1; -; mRNA.
DR EMBL; AC024887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017064; AAH17064.1; ALT_INIT; mRNA.
DR CCDS; CCDS46887.1; -. [Q5BVD1-1]
DR CCDS; CCDS54620.1; -. [Q5BVD1-3]
DR RefSeq; NP_001165218.1; NM_001171747.1. [Q5BVD1-3]
DR RefSeq; NP_078892.2; NM_024616.2. [Q5BVD1-1]
DR AlphaFoldDB; Q5BVD1; -.
DR BioGRID; 122794; 302.
DR IntAct; Q5BVD1; 74.
DR STRING; 9606.ENSP00000399392; -.
DR iPTMnet; Q5BVD1; -.
DR PhosphoSitePlus; Q5BVD1; -.
DR BioMuta; C3orf52; -.
DR DMDM; 317373287; -.
DR jPOST; Q5BVD1; -.
DR MassIVE; Q5BVD1; -.
DR MaxQB; Q5BVD1; -.
DR PaxDb; Q5BVD1; -.
DR PeptideAtlas; Q5BVD1; -.
DR PRIDE; Q5BVD1; -.
DR Antibodypedia; 2367; 19 antibodies from 9 providers.
DR DNASU; 79669; -.
DR Ensembl; ENST00000264848.10; ENSP00000264848.5; ENSG00000114529.13. [Q5BVD1-1]
DR Ensembl; ENST00000431717.6; ENSP00000399392.2; ENSG00000114529.13. [Q5BVD1-3]
DR Ensembl; ENST00000480282.5; ENSP00000420539.1; ENSG00000114529.13. [Q5BVD1-2]
DR Ensembl; ENST00000642661.1; ENSP00000495747.1; ENSG00000285394.3. [Q5BVD1-2]
DR Ensembl; ENST00000643248.3; ENSP00000495807.1; ENSG00000285394.3. [Q5BVD1-1]
DR Ensembl; ENST00000646545.1; ENSP00000493652.1; ENSG00000285394.3. [Q5BVD1-3]
DR GeneID; 79669; -.
DR KEGG; hsa:79669; -.
DR MANE-Select; ENST00000264848.10; ENSP00000264848.5; NM_024616.3; NP_078892.3.
DR UCSC; uc003dyq.5; human. [Q5BVD1-1]
DR CTD; 79669; -.
DR DisGeNET; 79669; -.
DR GeneCards; C3orf52; -.
DR HGNC; HGNC:26255; C3orf52.
DR HPA; ENSG00000114529; Tissue enhanced (pancreas, skin).
DR MIM; 611956; gene.
DR neXtProt; NX_Q5BVD1; -.
DR OpenTargets; ENSG00000114529; -.
DR PharmGKB; PA143485328; -.
DR VEuPathDB; HostDB:ENSG00000114529; -.
DR eggNOG; ENOG502S6A0; Eukaryota.
DR GeneTree; ENSGT00390000014574; -.
DR HOGENOM; CLU_1815206_0_0_1; -.
DR InParanoid; Q5BVD1; -.
DR OMA; GFMKYMM; -.
DR OrthoDB; 1078323at2759; -.
DR PhylomeDB; Q5BVD1; -.
DR TreeFam; TF330754; -.
DR PathwayCommons; Q5BVD1; -.
DR SignaLink; Q5BVD1; -.
DR BioGRID-ORCS; 79669; 8 hits in 1073 CRISPR screens.
DR GenomeRNAi; 79669; -.
DR Pharos; Q5BVD1; Tdark.
DR PRO; PR:Q5BVD1; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q5BVD1; protein.
DR Bgee; ENSG00000114529; Expressed in skin of leg and 96 other tissues.
DR ExpressionAtlas; Q5BVD1; baseline and differential.
DR Genevisible; Q5BVD1; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR033223; TTMP.
DR PANTHER; PTHR14636; PTHR14636; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..217
FT /note="TPA-induced transmembrane protein"
FT /id="PRO_0000248024"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 133..217
FT /note="LTDVYSTSPSLGRYFTSVEIVDFSGENATVTYDLQFGVPSDDENFMKYMMSE
FT ELVLGILLQDFRDQNIPGCESLGLDPTSLLLYE -> EVGLKPNPEALVGFE (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036120"
FT VAR_SEQ 133..217
FT /note="LTDVYSTSPSLGRYFTSVEIVDFSGENATVTYDLQFGVPSDDENFMKYMMSE
FT ELVLGILLQDFRDQNIPGCESLGLDPTSLLLYE -> NEVMEAGLCLKAVLYQVLEMKG
FT IHSVLQKRFCGLIQKHQQHQRGGDSFLSRFYSLALSPVKQLPSTASAGSSLDKGRKPAR
FT VGAIGSAGMSHCWRSLVFCLFLFCFVLFFETGSRSVA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036121"
FT VARIANT 66
FT /note="L -> P (in dbSNP:rs16859172)"
FT /id="VAR_059736"
FT VARIANT 111
FT /note="I -> V (in dbSNP:rs16859190)"
FT /id="VAR_027203"
FT VARIANT 144
FT /note="G -> S (in dbSNP:rs340167)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:15737651"
FT /id="VAR_027204"
FT CONFLICT 1
FT /note="M -> V (in Ref. 2; BAB15569)"
FT /evidence="ECO:0000305"
FT CONFLICT 123
FT /note="E -> K (in Ref. 2; BAB15569)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 24295 MW; 9240342865DBD743 CRC64;
MDLAQPSQPV DELELSVLER QPEENTPLNG ADKVFPSLDE EVPPAEANKE SPWSSCNKNV
VGRCKLWMII TSIFLGVITV IIIGLCLAAV TYVDEDENEI LELSSNKTFF IMLKIPEECV
AEEELPHLLT ERLTDVYSTS PSLGRYFTSV EIVDFSGENA TVTYDLQFGV PSDDENFMKY
MMSEELVLGI LLQDFRDQNI PGCESLGLDP TSLLLYE
