TTMP_MOUSE
ID TTMP_MOUSE Reviewed; 218 AA.
AC Q8C5C9; Q91YJ8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=TPA-induced transmembrane protein homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Single-pass type I membrane protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16579.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK078878; BAC37438.1; -; mRNA.
DR EMBL; BC016579; AAH16579.1; ALT_INIT; mRNA.
DR CCDS; CCDS49862.1; -.
DR RefSeq; NP_663364.2; NM_145389.2.
DR AlphaFoldDB; Q8C5C9; -.
DR STRING; 10090.ENSMUSP00000037651; -.
DR iPTMnet; Q8C5C9; -.
DR PhosphoSitePlus; Q8C5C9; -.
DR PaxDb; Q8C5C9; -.
DR PRIDE; Q8C5C9; -.
DR DNASU; 212998; -.
DR GeneID; 212998; -.
DR KEGG; mmu:212998; -.
DR MGI; MGI:2384848; BC016579.
DR eggNOG; ENOG502S6A0; Eukaryota.
DR InParanoid; Q8C5C9; -.
DR OrthoDB; 1078323at2759; -.
DR PhylomeDB; Q8C5C9; -.
DR BioGRID-ORCS; 212998; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8C5C9; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8C5C9; protein.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR033223; TTMP.
DR PANTHER; PTHR14636; PTHR14636; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..218
FT /note="TPA-induced transmembrane protein homolog"
FT /id="PRO_0000248025"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 113
FT /note="T -> M (in Ref. 2; AAH16579)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="G -> E (in Ref. 2; AAH16579)"
FT /evidence="ECO:0000305"
FT CONFLICT 143
FT /note="S -> A (in Ref. 2; AAH16579)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 218 AA; 24709 MW; C3C224679D981A9C CRC64;
MEEGSRSQSP REELELSMLD GPQEELTPLN NDLRIQPNSA EDPSPAQVGK ESPWSPCNKS
VVGKCKLWMV IVTIFLCFII VIVISLCLVG VTYIDEDENE ILELSSNKTF FITLKIPEEC
ANEEGLHHLL TERLTDTYRQ SPSLSRFFTS ADILDFSVEN ATVTYHLQFG VPSEDDDFMK
YMMSEELVLG IMRQSFHDKN ISTCESLGLD PESLLLYE
