TTN1_CAEEL
ID TTN1_CAEEL Reviewed; 18562 AA.
AC G4SLH0; A7DT28; G4SLD6; G5EDP1; G5EDT5; G5EF69; G5EFF0; Q65XY2; Q8ISF3;
AC Q8ISF4;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Titin homolog {ECO:0000303|PubMed:12381307};
DE EC=2.7.11.1 {ECO:0000269|PubMed:12381307, ECO:0000269|PubMed:18390597};
GN Name=ttn-1 {ECO:0000312|WormBase:W06H8.8g};
GN ORFNames=W06H8.8 {ECO:0000312|WormBase:W06H8.8g};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAN61517.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION OF ISOFORMS E; F; D; H
RP AND I, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, REGION,
RP AND REPEAT.
RX PubMed=12381307; DOI=10.1016/s0022-2836(02)00970-1;
RA Flaherty D.B., Gernert K.M., Shmeleva N., Tang X., Mercer K.B.,
RA Borodovsky M., Benian G.M.;
RT "Titins in C.elegans with unusual features: coiled-coil domains, novel
RT regulation of kinase activity and two new possible elastic regions.";
RL J. Mol. Biol. 323:533-549(2002).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16410549; DOI=10.1242/jcs.02728;
RA Zastrow M.S., Flaherty D.B., Benian G.M., Wilson K.L.;
RT "Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.";
RL J. Cell Sci. 119:239-249(2006).
RN [4] {ECO:0000305}
RP FUNCTION, CATALYTIC ACTIVITY, AND COFACTOR.
RX PubMed=18390597; DOI=10.1529/biophysj.108.130237;
RA Greene D.N., Garcia T., Sutton R.B., Gernert K.M., Benian G.M.,
RA Oberhauser A.F.;
RT "Single-molecule force spectroscopy reveals a stepwise unfolding of
RT Caenorhabditis elegans giant protein kinase domains.";
RL Biophys. J. 95:1360-1370(2008).
RN [5] {ECO:0000305}
RP FUNCTION, INTERACTION WITH ACTIN AND MYOSIN, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND REPEAT.
RX PubMed=20346955; DOI=10.1016/j.jmb.2010.03.032;
RA Forbes J.G., Flaherty D.B., Ma K., Qadota H., Benian G.M., Wang K.;
RT "Extensive and modular intrinsically disordered segments in C. elegans TTN-
RT 1 and implications in filament binding, elasticity and oblique striation.";
RL J. Mol. Biol. 398:672-689(2010).
CC -!- FUNCTION: Serine/threonine-protein kinase (PubMed:18390597,
CC PubMed:20346955). Key component in the assembly and functioning of
CC muscles. By providing connections at the level of individual
CC microfilaments, it contributes to the fine balance of forces between
CC the two halves of the sarcomere. The size and extensibility of the
CC cross-links are the main determinants of sarcomere extensibility
CC properties of muscle. In non-muscle cells, seems to play a role in
CC chromosome condensation and chromosome segregation during mitosis.
CC Might link the lamina network to chromatin or nuclear actin, or both
CC during interphase (By similarity). {ECO:0000250|UniProtKB:Q9I7U4,
CC ECO:0000269|PubMed:18390597, ECO:0000269|PubMed:20346955}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000269|PubMed:12381307, ECO:0000269|PubMed:18390597};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000269|PubMed:12381307,
CC ECO:0000269|PubMed:18390597};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000269|PubMed:18390597};
CC -!- SUBUNIT: Interacts (via C-terminus) with myosin. Interacts with actin.
CC {ECO:0000269|PubMed:20346955}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, A band
CC {ECO:0000269|PubMed:20346955}. Cytoplasm, myofibril, sarcomere, I band
CC {ECO:0000269|PubMed:20346955}. Nucleus membrane
CC {ECO:0000269|PubMed:16410549}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16410549}. Note=Localizes throughout the I-band
CC except for dense bodies and in the outer edge of the A-band
CC (PubMed:20346955). In embryo, co-localizes with lamin lmn-1 at the
CC nuclear membrane. The localization to the nuclear envelope is lmn-1-
CC dependent(PubMed:16410549). {ECO:0000269|PubMed:16410549,
CC ECO:0000269|PubMed:20346955}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=9;
CC Name=g {ECO:0000312|WormBase:W06H8.8g};
CC IsoId=G4SLH0-1; Sequence=Displayed;
CC Name=e {ECO:0000312|WormBase:W06H8.8e};
CC IsoId=G4SLH0-2; Sequence=VSP_058056, VSP_058057;
CC Name=f {ECO:0000312|WormBase:W06H8.8f};
CC IsoId=G4SLH0-3; Sequence=VSP_058055, VSP_058056, VSP_058057;
CC Name=d {ECO:0000312|WormBase:W06H8.8d};
CC IsoId=G4SLH0-4; Sequence=VSP_058052, VSP_058053, VSP_058054;
CC Name=c {ECO:0000312|WormBase:W06H8.8c};
CC IsoId=G4SLH0-5; Sequence=VSP_058050, VSP_058051;
CC Name=a {ECO:0000312|WormBase:W06H8.8a};
CC IsoId=G4SLH0-6; Sequence=VSP_058046, VSP_058047, VSP_058048,
CC VSP_058049;
CC Name=b {ECO:0000312|WormBase:W06H8.8b};
CC IsoId=G4SLH0-7; Sequence=VSP_058047, VSP_058048, VSP_058049;
CC Name=h {ECO:0000312|EMBL:AAN61520.1}; Synonyms=301kDa_1
CC {ECO:0000303|PubMed:12381307};
CC IsoId=G4SLH0-8; Sequence=VSP_058045, VSP_058056, VSP_058057;
CC Name=i {ECO:0000312|EMBL:AAN61521.1}; Synonyms=301kDa_1
CC {ECO:0000303|PubMed:12381307};
CC IsoId=G4SLH0-9; Sequence=VSP_058045, VSP_058055, VSP_058056,
CC VSP_058057;
CC -!- TISSUE SPECIFICITY: Expression is restricted to body wall, enteric and
CC vulval muscles. {ECO:0000269|PubMed:12381307,
CC ECO:0000269|PubMed:16410549, ECO:0000269|PubMed:20346955}.
CC -!- DEVELOPMENTAL STAGE: Expression begins at 2.5-fold stage and continues
CC throughout adulthood. {ECO:0000269|PubMed:12381307}.
CC -!- DOMAIN: The PEVK region may serve as an entropic spring to bear the
CC passive tension of the sarcomere. {ECO:0000303|PubMed:20346955}.
CC -!- DOMAIN: The BLUE region may serve as a force and thermal sensors.
CC {ECO:0000303|PubMed:20346955}.
CC -!- DOMAIN: The autoinhibitory domain may interact with the kinase
CC catalytic core thereby preventing its activation.
CC {ECO:0000303|PubMed:18390597}.
CC -!- MISCELLANEOUS: [Isoform e]: Produced by alternative splicing of isoform
CC g. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform f]: Produced by alternative splicing of isoform
CC g. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform d]: Produced by alternative splicing of isoform
CC g. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform c]: Produced by alternative splicing of isoform
CC g. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform a]: Produced by alternative splicing of isoform
CC g. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform b]: Produced by alternative splicing of isoform
CC g. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform h]: Produced by alternative promoter usage.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform i]: Produced by alternative promoter usage and
CC alternative splicing of isoform 301kDa_1. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AY130758; AAN61517.1; -; Genomic_DNA.
DR EMBL; AY130758; AAN61518.1; -; Genomic_DNA.
DR EMBL; AY130758; AAN61519.1; -; Genomic_DNA.
DR EMBL; AY130758; AAN61520.1; -; Genomic_DNA.
DR EMBL; AY130758; AAN61521.1; -; Genomic_DNA.
DR EMBL; BX284605; CCD72168.1; -; Genomic_DNA.
DR EMBL; BX284605; CCD72169.1; -; Genomic_DNA.
DR EMBL; BX284605; CCD72170.1; -; Genomic_DNA.
DR EMBL; BX284605; CCD72171.1; -; Genomic_DNA.
DR EMBL; BX284605; CCD72172.1; -; Genomic_DNA.
DR EMBL; BX284605; CCD72173.1; -; Genomic_DNA.
DR EMBL; BX284605; CCD72174.1; -; Genomic_DNA.
DR PIR; E89066; E89066.
DR PIR; T33247; T33247.
DR RefSeq; NP_001024198.1; NM_001029027.3.
DR RefSeq; NP_001024199.1; NM_001029028.3.
DR RefSeq; NP_001024200.1; NM_001029029.3. [G4SLH0-5]
DR RefSeq; NP_001024201.1; NM_001029030.3.
DR RefSeq; NP_001024202.1; NM_001029031.4.
DR RefSeq; NP_001024203.1; NM_001029032.3.
DR RefSeq; NP_001024204.1; NM_001029033.3.
DR IntAct; G4SLH0; 1.
DR STRING; 6239.W06H8.8g; -.
DR EPD; G4SLH0; -.
DR PaxDb; G4SLH0; -.
DR PeptideAtlas; G4SLH0; -.
DR PRIDE; G4SLH0; -.
DR EnsemblMetazoa; W06H8.8a.1; W06H8.8a.1; WBGene00006436.
DR EnsemblMetazoa; W06H8.8a.2; W06H8.8a.2; WBGene00006436.
DR EnsemblMetazoa; W06H8.8b.1; W06H8.8b.1; WBGene00006436.
DR EnsemblMetazoa; W06H8.8c.1; W06H8.8c.1; WBGene00006436. [G4SLH0-5]
DR EnsemblMetazoa; W06H8.8d.1; W06H8.8d.1; WBGene00006436.
DR EnsemblMetazoa; W06H8.8e.1; W06H8.8e.1; WBGene00006436.
DR EnsemblMetazoa; W06H8.8f.1; W06H8.8f.1; WBGene00006436.
DR EnsemblMetazoa; W06H8.8g.1; W06H8.8g.1; WBGene00006436.
DR GeneID; 266969; -.
DR UCSC; W06H8.8e.2; c. elegans.
DR CTD; 266969; -.
DR WormBase; W06H8.8a; CE52437; WBGene00006436; ttn-1. [G4SLH0-6]
DR WormBase; W06H8.8b; CE52423; WBGene00006436; ttn-1. [G4SLH0-7]
DR WormBase; W06H8.8c; CE36723; WBGene00006436; ttn-1. [G4SLH0-5]
DR WormBase; W06H8.8d; CE52449; WBGene00006436; ttn-1. [G4SLH0-4]
DR WormBase; W06H8.8e; CE52441; WBGene00006436; ttn-1. [G4SLH0-2]
DR WormBase; W06H8.8f; CE52428; WBGene00006436; ttn-1. [G4SLH0-3]
DR WormBase; W06H8.8g; CE52417; WBGene00006436; ttn-1. [G4SLH0-1]
DR eggNOG; KOG0613; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR GeneTree; ENSGT00940000163812; -.
DR InParanoid; G4SLH0; -.
DR OMA; QPEETKW; -.
DR OrthoDB; 592205at2759; -.
DR PRO; PR:G4SLH0; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00006436; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; G4SLH0; baseline and differential.
DR GO; GO:0031672; C:A band; IDA:WormBase.
DR GO; GO:0031674; C:I band; IDA:WormBase.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IPI:CAFA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017022; F:myosin binding; IMP:CAFA.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 11.
DR Gene3D; 2.60.40.10; -; 63.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00041; fn3; 9.
DR Pfam; PF07679; I-set; 37.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00060; FN3; 11.
DR SMART; SM00409; IG; 50.
DR SMART; SM00408; IGc2; 37.
DR SMART; SM00406; IGv; 4.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48726; SSF48726; 50.
DR SUPFAM; SSF49265; SSF49265; 6.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50853; FN3; 11.
DR PROSITE; PS50835; IG_LIKE; 38.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 1: Evidence at protein level;
KW Alternative promoter usage; Alternative splicing; ATP-binding; Coiled coil;
KW Cytoplasm; Disulfide bond; Immunoglobulin domain; Kinase; Magnesium;
KW Membrane; Metal-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW Repeat; Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..18562
FT /note="Titin homolog"
FT /evidence="ECO:0000305"
FT /id="PRO_0000435370"
FT DOMAIN 90..176
FT /note="Ig-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 406..493
FT /note="Ig-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 821..913
FT /note="Ig-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 943..1038
FT /note="Ig-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1135..1225
FT /note="Ig-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 1679..1762
FT /note="Ig-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3095..3177
FT /note="Ig-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3179..3264
FT /note="Ig-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3789..3878
FT /note="Ig-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 3897..3985
FT /note="Ig-like 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 4038..4125
FT /note="Ig-like 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT REPEAT 4599..4626
FT /note="PVET 1"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 4627..4665
FT /note="PVET 2"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 4666..4704
FT /note="PVET 3"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 4755..4787
FT /note="PVET 4"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 4788..4826
FT /note="PVET 5"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 4827..4865
FT /note="PVET 6"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 4917..4948
FT /note="PVET 7"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 4949..4987
FT /note="PVET 8"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 4988..5026
FT /note="PVET 9"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5027..5065
FT /note="PVET 10"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5066..5104
FT /note="PVET 11"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5105..5143
FT /note="PVET 12"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5144..5182
FT /note="PVET 13"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5183..5221
FT /note="PVET 14"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5273..5304
FT /note="PVET 15"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5305..5343
FT /note="PVET 16"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5344..5382
FT /note="PVET 17"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5434..5465
FT /note="PVET 18"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5466..5504
FT /note="PVET 19"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5505..5543
FT /note="PVET 20"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5544..5582
FT /note="PVET 21"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5583..5621
FT /note="PVET 22"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5622..5660
FT /note="PVET 23"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5661..5699
FT /note="PVET 24"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5700..5738
FT /note="PVET 25"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5739..5777
FT /note="PVET 26"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5778..5816
FT /note="PVET 27"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5817..5855
FT /note="PVET 28"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5856..5894
FT /note="PVET 29"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5895..5933
FT /note="PVET 30"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5934..5972
FT /note="PVET 31"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 5973..6011
FT /note="PVET 32"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6012..6050
FT /note="PVET 33"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6051..6089
FT /note="PVET 34"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6090..6128
FT /note="PVET 35"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6129..6167
FT /note="PVET 36"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6219..6250
FT /note="PVET 37"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6251..6289
FT /note="PVET 38"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6290..6328
FT /note="PVET 39"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6329..6367
FT /note="PVET 40"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6368..6406
FT /note="PVET 41"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6407..6445
FT /note="PVET 42"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6446..6484
FT /note="PVET 43"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6485..6523
FT /note="PVET 44"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6524..6562
FT /note="PVET 45"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6563..6601
FT /note="PVET 46"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6602..6640
FT /note="PVET 47"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6641..6679
FT /note="PVET 48"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6680..6718
FT /note="PVET 49"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6719..6757
FT /note="PVET 50"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6758..6796
FT /note="PVET 51"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6797..6835
FT /note="PVET 52"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6836..6874
FT /note="PVET 53"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6875..6913
FT /note="PVET 54"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6914..6952
FT /note="PVET 55"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6953..6991
FT /note="PVET 56"
FT /evidence="ECO:0000305|PubMed:12381307"
FT REPEAT 6992..6996
FT /note="BLUE 1"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 6997..7012
FT /note="BLUE 2"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7013..7028
FT /note="BLUE 3"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7029..7044
FT /note="BLUE 4"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7045..7060
FT /note="BLUE 5"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7061..7076
FT /note="BLUE 6"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7077..7092
FT /note="BLUE 7"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7093..7108
FT /note="BLUE 8"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7109..7124
FT /note="BLUE 9"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7125..7140
FT /note="BLUE 10"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7141..7156
FT /note="BLUE 11"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7157..7172
FT /note="BLUE 12"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7173..7188
FT /note="BLUE 13"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7189..7204
FT /note="BLUE 14"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7205..7220
FT /note="BLUE 15"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7221..7236
FT /note="BLUE 16"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7237..7252
FT /note="BLUE 17"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7253..7268
FT /note="BLUE 18"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7269..7284
FT /note="BLUE 19"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7285..7300
FT /note="BLUE 20"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7301..7316
FT /note="BLUE 21"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7317..7332
FT /note="BLUE 22"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7333..7348
FT /note="BLUE 23"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7349..7364
FT /note="BLUE 24"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7365..7380
FT /note="BLUE 25"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7381..7396
FT /note="BLUE 26"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7397..7412
FT /note="BLUE 27"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7413..7428
FT /note="BLUE 28"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7429..7444
FT /note="BLUE 29"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7445..7460
FT /note="BLUE 30"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7461..7476
FT /note="BLUE 31"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7477..7492
FT /note="BLUE 32"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7493..7508
FT /note="BLUE 33"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7509..7524
FT /note="BLUE 34"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7525..7540
FT /note="BLUE 35"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7541..7556
FT /note="BLUE 36"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7557..7572
FT /note="BLUE 37"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7573..7588
FT /note="BLUE 38"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7589..7604
FT /note="BLUE 39"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7605..7620
FT /note="BLUE 40"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7621..7628
FT /note="BLUE 41"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7629..7644
FT /note="BLUE 42"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7645..7652
FT /note="BLUE 43"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7653..7668
FT /note="BLUE 44"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7669..7684
FT /note="BLUE 45"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7685..7700
FT /note="BLUE 46"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7701..7716
FT /note="BLUE 47"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7717..7732
FT /note="BLUE 48"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7733..7748
FT /note="BLUE 49"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7749..7764
FT /note="BLUE 50"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7765..7772
FT /note="BLUE 51"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7773..7788
FT /note="BLUE 52"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7789..7804
FT /note="BLUE 53"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7805..7820
FT /note="BLUE 54"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7821..7836
FT /note="BLUE 55"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7837..7852
FT /note="BLUE 56"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7853..7868
FT /note="BLUE 57"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7869..7884
FT /note="BLUE 58"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7885..7900
FT /note="BLUE 59"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7901..7916
FT /note="BLUE 60"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7917..7932
FT /note="BLUE 61"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7933..7948
FT /note="BLUE 62"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7949..7964
FT /note="BLUE 63"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7965..7980
FT /note="BLUE 64"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7981..7996
FT /note="BLUE 65"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 7997..8012
FT /note="BLUE 66"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8013..8028
FT /note="BLUE 67"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8029..8044
FT /note="BLUE 68"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8045..8060
FT /note="BLUE 69"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8061..8076
FT /note="BLUE 70"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8077..8084
FT /note="BLUE 71"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8085..8100
FT /note="BLUE 72"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8101..8116
FT /note="BLUE 73"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8117..8132
FT /note="BLUE 74"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8133..8148
FT /note="BLUE 75"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8149..8164
FT /note="BLUE 76"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8165..8180
FT /note="BLUE 77"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8181..8196
FT /note="BLUE 78"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8197..8212
FT /note="BLUE 79"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8213..8228
FT /note="BLUE 80"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8229..8244
FT /note="BLUE 81"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8245..8260
FT /note="BLUE 82"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8261..8276
FT /note="BLUE 83"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8277..8292
FT /note="BLUE 84"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8293..8308
FT /note="BLUE 85"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8309..8324
FT /note="BLUE 86"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8325..8340
FT /note="BLUE 87"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8341..8356
FT /note="BLUE 88"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8357..8371
FT /note="BLUE 89"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8373..8388
FT /note="BLUE 90"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8389..8404
FT /note="BLUE 91"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8405..8420
FT /note="BLUE 92"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8421..8436
FT /note="BLUE 93"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8437..8452
FT /note="BLUE 94"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8453..8468
FT /note="BLUE 95"
FT /evidence="ECO:0000305|PubMed:20346955"
FT REPEAT 8469..8484
FT /note="BLUE 96"
FT /evidence="ECO:0000305|PubMed:20346955"
FT DOMAIN 8950..9041
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 10461..10553
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 12432..12547
FT /note="Ig-like 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 13963..14036
FT /note="Ig-like 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 14153..14247
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14253..14348
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14350..14448
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14451..14542
FT /note="Ig-like 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 14550..14634
FT /note="Ig-like 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 14638..14727
FT /note="Ig-like 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 14826..14920
FT /note="Fibronectin type-III 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 14937..15027
FT /note="Fibronectin type-III 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15180..15274
FT /note="Ig-like 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 15283..15371
FT /note="Ig-like 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 15383..15475
FT /note="Fibronectin type-III 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15503..15596
FT /note="Fibronectin type-III 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15599..15687
FT /note="Ig-like 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 15692..15786
FT /note="Ig-like 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 15791..15883
FT /note="Fibronectin type-III 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 15934..16189
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT DOMAIN 16268..16358
FT /note="Ig-like 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 16500..16575
FT /note="Ig-like 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 16605..16692
FT /note="Ig-like 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 16705..16789
FT /note="Ig-like 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 16829..16918
FT /note="Ig-like 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 16932..17025
FT /note="Ig-like 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 17037..17126
FT /note="Ig-like 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 17154..17245
FT /note="Fibronectin type-III 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 17249..17336
FT /note="Ig-like 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 17358..17447
FT /note="Ig-like 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 17457..17548
FT /note="Ig-like 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 17570..17661
FT /note="Ig-like 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 17676..17765
FT /note="Ig-like 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 17782..17873
FT /note="Ig-like 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 18008..18097
FT /note="Ig-like 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 18121..18213
FT /note="Ig-like 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 18224..18316
FT /note="Ig-like 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 18329..18417
FT /note="Ig-like 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 18429..18519
FT /note="Ig-like 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT REGION 384..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1336..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2155..2177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2298..2459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2614..2637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3362..3692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4553..4599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4634..4699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4750..4814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4826..4855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4912..4931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4950..4969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4989..5216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5267..5294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5306..5325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5345..5372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5428..6101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6127..6157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6214..6900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6930..8453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8599..8626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9079..9104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9147..9436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9481..9609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9702..10224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10239..10274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10539..11018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11030..11111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11123..11213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11225..11387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11420..11592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11624..11825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11872..11955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11996..12054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12397..12418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12537..12974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13026..13045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13065..13261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13283..13514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13553..13574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13594..13874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15011..15180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15470..15503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 16206..16264
FT /note="Autoinhibitory domain"
FT /evidence="ECO:0000269|PubMed:12381307"
FT REGION 16805..16827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 17121..17169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1766..1786
FT /evidence="ECO:0000255"
FT COILED 2011..2038
FT /evidence="ECO:0000255"
FT COILED 2065..2085
FT /evidence="ECO:0000255"
FT COILED 2205..2231
FT /evidence="ECO:0000255"
FT COILED 2606..2630
FT /evidence="ECO:0000255"
FT COILED 5212..5235
FT /evidence="ECO:0000255"
FT COILED 6984..7812
FT /evidence="ECO:0000255"
FT COILED 7876..8273
FT /evidence="ECO:0000255"
FT COILED 8316..8490
FT /evidence="ECO:0000255"
FT COILED 9371..9510
FT /evidence="ECO:0000255"
FT COILED 9577..9749
FT /evidence="ECO:0000255"
FT COILED 9822..9995
FT /evidence="ECO:0000255"
FT COILED 10046..10129
FT /evidence="ECO:0000255"
FT COILED 11018..11064
FT /evidence="ECO:0000255"
FT COILED 12408..12428
FT /evidence="ECO:0000255"
FT COILED 12797..12828
FT /evidence="ECO:0000255"
FT COILED 12980..13103
FT /evidence="ECO:0000255"
FT COILED 13237..13380
FT /evidence="ECO:0000255"
FT COILED 13455..13628
FT /evidence="ECO:0000255"
FT COMPBIAS 2307..2341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2355..2370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2402..2418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2429..2449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3384..3398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3458..3472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3603..3618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3642..3668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3669..3684
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4561..4582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4641..4661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4680..4699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4764..4783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5041..5056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5119..5134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5198..5216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5442..5461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5480..5495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5559..5578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5598..5617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5637..5656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5676..5695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5715..5734
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5754..5776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5793..5812
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5832..5851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5949..5971
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5988..6007
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6027..6049
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6066..6085
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6226..6246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6266..6285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6305..6324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6344..6363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6383..6402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6422..6441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6461..6480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6500..6519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6539..6561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6578..6597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6617..6636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6656..6678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6968..8453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8612..8626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9154..9183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9193..9214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9215..9230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9231..9267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9268..9296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9297..9347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9348..9369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9370..9436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9481..9550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9551..9573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9574..9609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9702..9797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9798..9819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9822..10021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10022..10041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10042..10150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10161..10195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10205..10224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10239..10253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10560..10604
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10610..10638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10639..10665
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10693..10750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10757..10771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10775..10789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10803..10826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10827..10887
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10905..10924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10946..10991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10995..11009
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11048..11065
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11087..11111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11134..11150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11156..11172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11187..11207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11225..11329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11351..11385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11422..11468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11476..11490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11501..11519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11550..11567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11577..11592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11624..11700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11721..11739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11740..11769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11776..11795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11811..11825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11895..11937
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11938..11955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11996..12013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12014..12028
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12398..12414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12551..12585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12586..12601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12607..12692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12725..12744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12766..12834
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12849..12878
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12887..12955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13065..13126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13135..13168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13178..13192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13202..13261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13283..13433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13434..13452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13455..13514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13594..13654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13655..13669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13672..13686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13700..13748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13760..13784
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13824..13851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15033..15056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15070..15116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15131..15180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17121..17154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 16055
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 15940..15948
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 15963
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT DISULFID 842..897
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1700..1751
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 3919..3969
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 4059..4109
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 14568..14618
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 16290..16342
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 16508..16571
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 16627..16677
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 16726..16778
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 17379..17431
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 17478..17530
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 17697..17754
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 18143..18195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 1..15826
FT /note="Missing (in isoform h and isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_058045"
FT VAR_SEQ 296
FT /note="V -> ERRTDGKLEKFQIEFKKKLVQI (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_058046"
FT VAR_SEQ 376..802
FT /note="DAASIVESRFHPQPPKPPRAGTSRRFLPEPPKFVTTLPSVITVNAEEKLVLS
FT VDVQAIPAAEFAWHVNGFEVKKSQSVVLLDEHNKSTLVLHPPVKQGKYKVTARNDVGSD
FT SVTTQVTRIGEVKDGAGSEPPDIVESAVTVTCSHEEDVGSHSSLQTVRRIQEMQEEDEV
FT DPIKPFIEATSPKVKESVEHPFANILNPKKREERLSPSGKGKHLLFAPRITAHPSESVF
FT KILDGSPLKLRVMASSLPPATFLWMLNNFELRSNQNVTIRNDEENSSEIEFQKAPNGNV
FT TVSAKNHLGEDRWTGKVILQYESPPPGQKITTIEKVTESWTLEEAVITQVVPTAADPGD
FT RIVIIVRFDENKTSNCQFNWTINGVNIEKLEENLVAVESTEFESSLIVEKLEEQLCGEV
FT VCVVKNQHGEVFSSSAHLRIR -> G (in isoform a and isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058047"
FT VAR_SEQ 1123..1129
FT /note="EEEDNQI -> VSLRLKI (in isoform a and isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058048"
FT VAR_SEQ 1130..18562
FT /note="Missing (in isoform a and isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058049"
FT VAR_SEQ 3178..3215
FT /note="KTERSEEQCEETIIPRGVVATIQCQTSEPQESIQWSKD -> SVCISNVEFR
FT VAHLCVNSLTSTLHALKRKRISNNSLHN (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_058050"
FT VAR_SEQ 3216..18562
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_058051"
FT VAR_SEQ 5409..5428
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_058052"
FT VAR_SEQ 10572..10598
FT /note="VSKKPENTKESEGHKKRDRKESEDHDE -> GKFRRNWKVTVNHRSLNLINV
FT ACCVIA (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_058053"
FT VAR_SEQ 10599..18562
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_058054"
FT VAR_SEQ 16191..16205
FT /note="Missing (in isoform f and isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_058055"
FT VAR_SEQ 18521..18534
FT /note="VLSMFYSSLFLVVF -> GSSAALPQRRTIRR (in isoform e,
FT isoform f, isoform h and isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_058056"
FT VAR_SEQ 18535..18562
FT /note="Missing (in isoform e, isoform f, isoform h and
FT isoform i)"
FT /evidence="ECO:0000305"
FT /id="VSP_058057"
SQ SEQUENCE 18562 AA; 2056723 MW; B0E1A953AE6231FB CRC64;
MEGNEKKGGG LPPTQQRHLN IDTTVGGSIS QPVSPSMSYS TDRETVMRSA SGHATVAETH
LIRSIGSQSQ SYTEEHWSSE ITSFVALAPP KFIQVIKAYR VHSTDTISLV VEVASDPPAI
FEWFYNEKSV LQDRDRFQVG HGINISRLKV SRPEQGVYKC VTRNPAGVST SYGYITVNAD
REHLSSSKED MRLQRQHSVT YHQAPRFLTQ VPNLFVTAGS NVIIDVEVDA NPPARFSWFV
NGKEYRDSIH GVEMFSPDVN RSVVRFSIPV AGEYKVVASN VHGSAMSCGH VDIQKVIELE
ESTLTTSTTA FDPMTTSMRA LGNNGRNSRQ AVNMFELNYT QRSSSVPRGV RHLESHIEVS
NMTGEEKKTQ QQTRTDAASI VESRFHPQPP KPPRAGTSRR FLPEPPKFVT TLPSVITVNA
EEKLVLSVDV QAIPAAEFAW HVNGFEVKKS QSVVLLDEHN KSTLVLHPPV KQGKYKVTAR
NDVGSDSVTT QVTRIGEVKD GAGSEPPDIV ESAVTVTCSH EEDVGSHSSL QTVRRIQEMQ
EEDEVDPIKP FIEATSPKVK ESVEHPFANI LNPKKREERL SPSGKGKHLL FAPRITAHPS
ESVFKILDGS PLKLRVMASS LPPATFLWML NNFELRSNQN VTIRNDEENS SEIEFQKAPN
GNVTVSAKNH LGEDRWTGKV ILQYESPPPG QKITTIEKVT ESWTLEEAVI TQVVPTAADP
GDRIVIIVRF DENKTSNCQF NWTINGVNIE KLEENLVAVE STEFESSLIV EKLEEQLCGE
VVCVVKNQHG EVFSSSAHLR IRDDDSSFEI VPPNLPEECA PKIVEPLHSA SFLDGQAMSL
RCKITANPSA AVVWSKDDVN VEDWVLNKDV TTTVLDGGVC ELLNPECFAE DAGLYKCTAT
NPHGTAETAA FINVEGAEYI KDHEEAEISE SVLTDDVHII LPPKFIETLT AETDNFQQLG
YVRMVATVRS VAPITVSWQK DGMDIYENEK YEVMQFADGA QILTIRAPTN LDSGVYTCTA
ESEHGVSNSS CQVELTISAE SSPESFEKVE ITPPEEVKET GIDDDIEVIL KEEVSGTAQI
EKREEEFKLL VKVADQVAST LVANVFLEAV HEAVKKIVET EDEEEDNQIE ATQEPRFETS
TDEYHVKENG TIKMAATISG HPTPFLEWYF GEEKLQVSQN VSMYYEAGTS AIILKNVQKR
QGGNYFLRAH NCHGESILPM KLTVDPIEAV THVLETSIPK VVVEQDAKEE EVRRAAEIIS
EQFAQLWVQD AQTEAVSAQA HQTPVVAEQA SEEPTLPEVV AALQEQKPSV EKAPQPQFEV
LETEDQDVVE QMQKQLPPVQ KSMSVQEEKA SSQRTPSPMN YEDKVKTIQS NLLRVNSHEA
MEPIEATNLL LNTALQLKNE HVCDETTTVI VTQQPQKYDQ LVTVVESNIE YHALRLSTSS
SSPLKFIDLE TIIQKPSTSC ESIDRMFVEK SKRTANAQHR IVVLQGMSNT FHNAITWSLK
KVKKLVGDAE AKAYADVEVV KQDETNEQVM TIIDNDTIVP QLLQVAAAAN KLKLENVSVA
LIKEGDRAHQ ELVIEYESSI DEPMFEPVHN TSHLTFHQQQ PTGPDQHVWS RRSKFEEDEA
HVVAVFVEVD ANCPDQSVEI VATVNAAYEG DNRQGIEDEP FTEVSQSLAT ESSAAPQAPK
FLRKLVNCFG RIGEPVQLKC LIAGMPQPEI EWTVDGDPIV PNDEYSIVYE DGVCILRIES
TLIEDEGEYC CTASNVAGTT FSKCYLKLSE ADDDAVDLLR QLSEIKIIDP TLSTGYPMSM
ISDEENTSHQ LLSNVLLTDK EVPITATYNE DLSRAESFRR FFESAETTVK VTELYQGESV
EAQFQQPEKR EQVSTSNTDV MFVNQKVDVM ESTVSTVGNA VRQSVSSSTN SWDYMFNDPF
PESQEINVIE NELYEPRVPL LPQKLSYKGQ EIFANTNTVE RNSKAGAKAK GEVENLKKCV
ETLLLFDAEM DMKDIKESSP KKEIISKKDQ QSLDDQIKVT QQILKDVERD LNKMERTSPG
KSLSPNKRTF APKDVEDIEA AIFSISDQLA DRQSSEEALR EALQEMILSN SSPMKELSRN
NETSKPEVLK SEIQKIPEVE TKISEVYPIV KLKQAISAIE NSLLEDTEVT EIMKRKGSDK
DKRKATRIKR VPSAHSARIT PITSNLRDRL NQLHQLTVSE DSGSLKQNEE AKEIQELFVK
IEKEINTIAE LCKEKMTKKG ADTVTHVLNS VLQHVASIIN VILVAQDHQP IEVHAETTKT
AEVSVWYSFD VHPESEDIIG IVDEEPTNRR PSSTPRGSTR SSNLTTSQDS QATTKMTVSS
EDTIEAPIAP PRKGRSLSRD AERLLEIQPR APPRRSRQSG DTLSPEPTPV LTLVKSDETP
APVRPPRSRS RHSGDELAET SPEAQPIRPP RSHSRHSGDE LEEVQPVRPP RSKSKTADAN
CLQIESMDES QYSLSCIHIQ KTNFAFTNST HETSNASVVV DLRNMAQLEC TVQSLDDLAS
IQMLCEESDY PSDTDRSLLL AGTVRYFNRA SPSLHEVSPS LNMESVSMDL KPETEPEEIV
QDVYVNVELH SVPSLSSLVE VNPNTLMQTL ASEKSSLKAA EEDEKEGEEE GEEEVTADVS
FIGRSVLSTE TLDVVLEEKD MSQMNSTLPL DYERAFSSNT IRETDILSDE SITVDSSYHK
SPEPTVDFAR SQVKSEEVTE NFSLIHKPAR RRVTGIVVNS LIYTIAANIA EDNTFDVDVV
QEPQRYNISI KVIEDIVDFT SLTIMSDCED DPPADVLVLK QDTSKLQALS YDDISVATTR
TGITVSIVAR SLNDGIYASL EEIAWGEVEM TVPDIMQMST EEKSSLQFNV TVSESNLEEA
KSLKSQVSFR SSQNSVSEMD NTISSTATIS IPSYVVKLES TATITCELNN YLPKNCTIDW
YCGKTKIIID HEQFDRISHD LLEVLIIRSV EAINGNLYSL KINEDLFPVA YLIVENTNLT
TSANILTRPE TQFVMEGQPT VITVELDDPN VIVNWLKDRR PLHENERIRL ETDGQGNHRV
IIPNTCVGDQ GTYLALTSSE SVAITLVVEE RIEEKEVMVI ASGTESEEDD VQEYLVPPGS
TATIACELEE CELKRSIRWL RDGKDIRFEQ GKTEHVQNGL KHYLVVHDAT SLDSGLYKTE
RSEEQCEETI IPRGVVATIQ CQTSEPQESI QWSKDGNIIP SDISRFEFRS LDNNQSHEMV
ISNISWSDAG VYSVLINGKS SFVSKIVVVE SELITQSVEE EPEAEPEIDV SLHIVESEQI
IELNVPQSPK LGASHETLVP IGQDDIEVID KQEAAPVVES IEETSSIGSE EFEIIEKFTE
EEVPKVAEPS EPTQADVPKI AAPLEQSQIQ QEVPTVAAPS EPTQADVPKE AAPSEPSQAD
VPKVAAPLEQ TQIQQEVPMV AAPLEPTQAD VPKVAAPLEQ SQIQQEVPTV AAPSEPTQAD
VPKEAAPSEP SQADVPKVAA PLEQTQIQQE VPMVAAPLEP IQEEVPKEAA PSEPTQEDVP
KGAAPLEPTQ EDVPKEAAPS GPTQEDVPKE EAPSEPTQED VPKEAAPSEP TQENVPKEAA
PSEPTKDVPK EAAPSEPIQE EVPKEATLSE PTQEQSEVSK RSEPVEPTQI QQAASEEETP
LEETNETVVQ TNEDVKEAEV PENAEAQKVV DSSDLQVAAS EIAHLAIDEA VLETSNQPSQ
FDSLQEQKPS VVHENEHVRS VCVDLTFSRD SEQIVSDVIV AEVGYDEDEC STIADTITSL
SSSPLYTAPV FTERLPSSAC FANSKLTLEV MFSGVPQPTI SWLIDDHELV SDGERISIKC
ENGVSAIRFF NVDRNAGGFL KCRATNCAGQ VETSCEIVAA DEISVISDSS ITSSTRPHFV
VPLPERVTHT VNDHITIKCK FSGQPLPAAM WEKDGVLLDL QKYQVTTEDG TSILKIESAS
LDDKAVYTCT IANEAGCEST SCTIDVVDDH LGLQQTGLHV MCERDQNDVE LDILVQSPNH
LGVTFNFPPV NRTLARQPPY FLLPLSDKVV IDEKCTLKCV VMGIPLVIVK WIVDGVVVTE
DDNHEIHFED GIALLRMKNI KKDKSVVQCE AINCKGKVTT SCVLTKCGVE ESEAGDLQKP
SFVLSLKDTC TTTDHATLKC IVVGTPLPDV SCSFNGVTDN SKIRSEDGIV LIQVNDVTEE
GIVVECTISN ETGSSTSNCV VKIIKQEEKN YQRPIIVFNQ AGSVNNEREL SVKVGVIASP
EPTLFWKHNG KSIEEGGDYY LIFEDGIGIL KVFNIQDGSH EFTCIAKNEY GQTTVEIPVE
IGLKTENKLT LVKTLNDIAV VDDIVQLKIV AEGDLPIEFK WFEDGQILED DSSHKITVDK
CISTLQLKLE ETGTRIITCE VSNSSSKVNA SCNVERVHNT VSDFVMTNDN STRFLAVGRK
CTRERNNTIL KAVVVARENI GDICEIDGEK IPDAYIEGNS LSIKVDTLSK KLSNVSFKVS
ASEGKVFETR KIEIAQEDTD EENFEINYSL RIDEQSGNTT YTFENSELYQ GNQSRELDNT
ERNFTVNKEK DESKKPSEVQ PAEIVEQKDV PVQETSAPTV EKLAPVESKE TPEVQAAEIV
EQKDVPVPET RAPTVEPTVE KHTPVDSKET SEVEPAEIVE QKDVPVPETS APTVEPTVEK
HTPVESKEKS EVQPAEIVEQ KDVTCEEEIK ELLTEVEVEL FFSQAEVFSG LELDLLMECS
EYVTTSIQKG STAAPAQEPT VEKLAPVESK ETSEVEPAEI VEQKDVPVPE TSAPSVEPTV
EKLAPVESKE TSEVQQAEIV EQKDVPVPET SAPSVEPTVE KLAPAESKET SEVQPAEIVE
QKDVTCEEEI KELLTEVEVE LFFSQAEVFS GLELDLLMEC SEYVTTSIQK GSTAAPAQEP
TVEKLAPVES KETSEVQQAE IIEQKDVPVP ETSAPTVEPT VEKLKPVESK ETSEVQQVEI
IEQKDVPVPE TSAPTVEPTV EKLAPVESKE TSEVQQAEII EQKDVPVPET SAPTVEPTVE
KLKPVESKET SEVQQVEIIE QKDVPVPETS APTVEPTVEK LAPVESKETS EVQQAEIIEQ
KDVPVPETSA PTVEPTVEKL KPVESKETSE VQQVEIIEQK DVPVPETSAP TVEPTVEKHA
PVESKETSEV QPAEIVEQKV VPVPETSAPT VEPTVEKLAP VESKETPEVQ PAEILEQKDV
TCEEEIKELL TEVEVELFFS KAEVFSGLEL DLLMECSEYV TTSIQKGSTA APAQEPTVEK
LAPVESKETS EVEPAEIVEQ KDVPVPETSA PTVEPTVEKL KSVESKETSE VQQAEIIEQK
DVPVPETSAP TVEPTVEKLA PVDSKETSEV EPAEIVEQKD VTCEEEIKEL LTEVEVELLF
SQAEVFSGLE LDLLMECSEY VTTSIQKGST AAPAQEPTVE KLAPVESKET SEVEPAEIVE
QKDVPVPETS APTVEPTVEK LKSVESKETS EVQQAEIIEQ KDVPVPETSA PTVEPTVEKH
APVESKETSE VQPAEIVEQK VVPVPETSAP TVEPTVEKLA PVESKETSEV EPAEIVEQKD
VPVPETSAPT VEPTVEKLAP VESKETSEVE PAEIVEQKDV PVPETSAPTV EPTIEKLAPV
ESKETSEVEP AEIVEQKDVS VPETSAPTVE PTIEKLAPVE SKETSEVEPA EIVEQKDVSV
PETSAPTVEP TVEKLAPVES KETSEVEPAE IVEQKDVPVP ETSAPTVEPT VEKLAPVESK
ETSEVQPAEI VEHKDVQVPE TSSPTVEPTV EKLAPVESKE TSEVEPAEIV EQKDVPVPET
SAPTVEPTVE KLAPVESKET SEVEPAEIVE QKDVPVPETS APTVEPTVEK LAPVESKETS
EVQPAEIVEQ KDVSVPETSA PTVEPTVEKL APVESKETSE VQPAEIVEQK DVPVPETSAP
TVEPTVEKLA PVESKETSEV QPAEIVEHKD VQVPETSSPT VEPTVEKLAP VESKETSEVE
PAEIVEQKDV PVPETSAPTV EPTVEKLAPV ESKETSEVQP AEIVEHKDVQ VPETSAPTVE
PTIEKLAPVE SKETSEVEPA EIVEQKDVSV PETSAPTVEP TIEKLAPVES KETSEVQPAE
IVEHKDVQVP ETSSPTVEPT VEKLAPVESK ETSEVQPAEI VEQKDVTCEE EIKELLTEVE
VELFFSQAEV FSGLELDLLM ECSEYVTTSI QKGSTAAPAH EPTVEKLAPV ESKETSEVEP
AEIVEQKDVP VPETSAPTVE PTVEKLAPVE SKETSEVEPA EIVEQKDLPV PETSAPTVEP
TVEKLAPVES KKTSEVEPAE IVEQKDVPVP ETSAPTVEPT VEKLAPVESK ETSEVEPAEI
VEQKDVPVPE TSAPTVEPTV EKLAPVESKE TSEVEPAEIV EQKDVPVPET SAPTVEPTIE
KLAPVESKET SEVEPAEIVE QKDVSVPETS APTVEPTIEK LAPVESKETS EVEPAEIVEQ
KDVSVPETSA PTVEPTVEKL APVESKETSE VEPAEIVEQK DVPVPETSAP TVEPTVEKLA
PVESKETSEV QPAEIVEHKD VQVPETSSPT VEPTVEKLAP VESKETSEVE PAEIVEQKDV
PVPETSAPTV EPTVEKLAPV ESKETSEVEP AEIVEQKDVP VPETSAPTVE PTVEKLAPVE
SKETSEVQPA EIVEHKDVQV PETTATTFEP TKEKLAPVDS KETSEVQTAE IVEQKDVPVP
ETSATTVEPT KEKLAPGESK ETSEVQQAAI VEQKDVAVPE TSATTVEPTK EKLAPVESKE
TSEIQTAEIV EQKDVPVPET STSYVEPTKE KLAPGESKET SEVQQAAIVE QKDVPVPETS
ATTVEPTKEK LAPVESKETS EIQQAAVVEQ KDVPVPETSA TTVEPTKEKL APVESKETSE
VQQAAIVEQK DVPVPEANAP TFEPTVEKLA PVESKETSEV QQAAIVEQKD VPVPEANAPT
VEPTVEKLAP VESKETSVES KETQADAKLK KEKDDKHKQE ADAKLQKEND DKLKQEADAK
LKKENDDKLK QEADAKLKKE NDDKLKQEAD AKLKKENDDK LKQEAAAKLK KENDDKLKQE
ADAKLKKEND DKLKQEADAK LQKENDDKLK QEADAKLQKE NDDKLKQEAD AKLQKENDDK
LKQEADAKLQ KENDDKLKQE ADAKLQKEND DKLKQEADAK LKKENDDKLK QEADAKLKKE
KHDKLKQEAD AKLQKENDDK LKQEADAKLQ KENDDKLKQE ADAKLQKEKD DKLKQEADAK
LKKEKDDKLK QDADAKLQKE KDDKLKQEAD AKLKKEKDDK LKHEADAKLQ KEKDDKLKQE
ADAKLKKEKD DRLKKDADAK LQKEKDDKLK QEADAKLKKE KDDKLKHEAD AKLQKEKDDK
LKQEADAKLK KEKDDKLKQE ADAKLQKEKD DKLKQEADAK LKKEKDDKLK QEADAKLQKE
KDDKLKQEAD AKLKKEKDDK LKQEADAKLQ KEKDDKLKQE ADAKLKKEKD DKLKQEADAK
LKKEKDDKLK QDADAKLQKE KDDKLKQEAD AKLKKEKDDK LKHEADAKLK KEKDDKLKQE
ADAKLKKEKD DKLKQDADAK LKKEKDDKLK HEADAKLQKE KDDNFKQEAN AKLQKEKDDK
LKQEKDDNFK QEANAKLQKE KDDKLKQEKD DKLKQEADAK LKKEKDDKLK QEADAKLKKE
KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE ADAKLKKDKD DKLKQEADAK
LKKDKDDKLK QEADAKLKKE KDDKLKQEKN DKLKQEADAK LKKEKDDKLK QEADAKLKKE
KDDKLKQETD AKLKKDKDDK LKQEADAKLK KDKDDKLKQE ADAKLKKDKD DKLKQEADGK
LKKEKDNKLK QEADGKLKKE KDNKLKQEAD AKLKKEKDDK LKQEADAKLK KEKDDKLKQE
ADAKLKKDKD DKLKQEADAK LKKEKDDKLK QEADAKLKKD KDDKLKQEAN AKLQKEKDDK
LKQEADAKLQ KEKDDKLKQE ADAKLKKEKD DKLKQEADAK LQKEKDDKLK QEADAKLKKE
KDDKLKQEAD AKLQKEKDDN FKQEANAKLQ KEKDDKLKQE KDDKLKQEAD AKLKKEKDDK
LKQEADAKLK KDKDDKLKQE ADAKLKKEKD DKLKQEADAK LKKEKDDKLK QEADAKLKKD
KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE TDAKLKKDKD DKLKQEADAK
LKKEKDDKLK QEADAKLKKE KDDKLKQEAD AKLKKEKDDK LKQEADAKLK KDKDDKLKQE
ADAKLKKDKD DKLKQEADGK LKKEKDNKLK QEADGKLKKE KDNKLKQEAD AKLKKEKDDK
LKQEADAKLK KDKDDKLKQE ADAKLKKEKD DKLKQEADAK LKKEKDDKLK QEADAKLKKD
KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE ADAKLKKDKD DKLKQEADAK
LKKDKDDKLK QEADAKLKKE KGDKLKLEDQ TNQSRIFEET SIEVTSLLKC KQQAIIVSKS
FALCERVVLN AEEPFTLEVF CNAVFVKQRT DKIGIGIIFE RSGASKKDES RPDRLDDNCV
LTDVTDGLSI LSPPPKAKKH LKKKKKHHKK EKIAVKETEQ DEKTVSHLKP EISGMERKRS
NSGSSDIFVD VDIEAGEESI HTDALVDLNF YDYDQMELSI FEDYDSDDDS ASIDCDVSLS
NVAADDGIDV FPSDGDTQEV EQKVTLPKKH QSDEDVISKE EENLETSVSY GSIEETVSFT
IGTGQSIIEH PKSHAVGQMN SEVIIKCKTS QPISDAKWFC NGMVLLPDEQ VNMTVTGCEA
VLRLVKFLPQ NKGNYHVLID GSIGSQPAIL SGPVPPVILN KLTKPITHQA GKSFTYKFNF
MGAPAPRLRV LSNGEPVSFD VKYEIYDNIA SLYIPKMSKR DGGEYTVVLE NKYGKDESDL
HITMVDTPLK PRKAQLVALT DTSATFKWLP PHTGESDILH YIVMRRSTES RRWRNIGHVQ
EKTFTAIELV PNEFYAFRIV AVNGFGEGAP SEIIEVNTLD YDQEESFDFA GEEELKLDDV
QVNNEVVTEI TIEESEVTIE EHRKLKKKSK KSKKTTDEPE LDSEIALEVS SDITSSLEIT
TESTIPDTAP ESQETLNVEI AVTETTVQKI TNPSDESAKK DVNEDTAVSS IVKKDDKDVN
KKSLPESGLT TKKEIQGKPE KKIMKKKTEK ADSSISETSE TLTKDLTQTK QSEPEPAKRT
TETSVQDEVK RKTETTSKSK QTTEEHPQPG GKSDSSISST SDASEVKQVQ QSESEAQKVT
EKPETAKLES KSKMTEDTTK ESDNKETVDE KPKKKVLKKK TEKSDSTISE TSETSAVESA
GPSESETQNV AAVDKEKKQK ETDEKQKLEA EIAGKKSTEQ KSKLEAEAKL KRAAEEDAAK
KQKEKTEAAS KKAAAEKLEL EKQAQINKAA EADAVKKQNE LDEQNKLEAT KKLAAEKLKL
EEQSAAKSKQ AAEEQAKLDA QTKAKAAEKQ TGLEKDEKSN KDSGSNETVE EKPKKKVLKK
KTEKSDSSIS QKSDTSKTVA ESAGSSESET QKVADATSKQ KETDKKQKLE AEITAKKSAD
EKSKLETESK LIKAAEDAAK KQKEKEDKLK LEADVASKKA AAEKLELEKQ AQIKKAAEAD
AVKKQKELAE KQKLESEAAT KKAAAEKLKL EEQAQINKAA EADAVKKQKE LDEKNKLEAN
KKSAAEKLKL EEESAAKSKQ TVEEQAKLDA QTKEKTAEKQ TGLEKDDKST KDSESKETVD
EKPKKKVLKK KTEKSDSSIS QKSVTSKTVV ESGGPSESET QKVADAARKQ KETDEKQKLE
AEITAKKSAD EKSKLEAESK LKKAAEVEAA KKQKEKDEQL KLDTEAASKK AAAEKLELEK
QAQIKKAAEA DAVKKEKELA EKQKLESEAA TKKAAAEKLK LEEQKKKDAE TASIEKQKEQ
EKLAQEQSKL EVDAKKSAEK QKLESETKSK KTEEAPKESV DEKPKKKVLK KKTEKSDSSI
SQKSDTAKTV AESAGQSDSE TQKVSEADKA HKQKESDEKQ KLESEIAAKK SAEQKSKLET
EAKTKKVIED ESAKKQKEQE DKKKGDDSAK KQKDQKEKQK LESEATSKKP TSEKQKDEKT
PQEKAKSENE TVMTTEPQQL EVKSEPKKSD KTETVEKEVA SSTEKSDDSK TKEPKEKKKI
IKKKKDTTKP QEASKELSSD ESRIDLESDI SLSLDTVTES DDLSTASTIK LQKESDESGI
DSRMGQTSEA EDSPFISQPV SATVTEMAGE AKFTVKFSRK PIYVKWMRDD REIRVAYGKA
SVETTDDSSV LVIKNIDGKD VGNIYAVFDS EYRSAMARLD LRVPCKITLE SSSNAPEIVA
GKNLDLSFKI SGYPLPTNIE LLHNNENLRT RSDVTDFDDS ISIRMKRLKL EDSGEIKIIG
KNDSSEDQLR IPINVIEVTS KPTSLQVTST ERETVTLTWS LPTELNGSNV NEYLVERKTV
DGGRWRHACT VTDSRAVVDG LFSGTEYVFR VVAVNGAGQS APSDTIEATT QAEEEIDETV
PTSPVEKVKE PVSKKPENTK ESEGHKKRDR KESEDHDENN LGKSGKDEFA TSGESGTSNQ
NEESAQLNTS FTSTEQHGQT EKQVRKGTRK SLTRSLNIRE SDIDADVVEV EYDEQGDDIP
SDPTTSGTYA FDKIEEEPAR TSGEMAMAEK DSDAMEVRGL NKKLSKKGGK EGTSTEKSSS
KTKKQEKSAL SVQEMNKSLK KKGEKGEAET AASDFIENAD QTGMSIQDLN KSMKKKVESG
EATGQINDAS NNKDADELSI QDSQQSLKKK SENESVTGEQ LDKSQEVEDD KMTIQSLKKS
IKKKPESREV SGGKSEKSKE KESDEMSIQQ LNKSVKKKPE NEAVTQGKSG KSQEQESDKM
SIQALNKSMK KKDGVDGVEG NINIGRSDGD QLSVNDIDAE LSTSEQVENA SQNLGATADS
DGDSLSLQTL KKRISKKGIH GEAESKLGEK QSGSDSFTLQ DLYEELKAKE DAVEAGAETS
NADQSAEKTS LEVRDMKKKM KKKQVSGTAE NLIGESNRDE TSMEIRDLNT QHSNQTGEDE
SSTFNFGQKD QEQYSMVMKD VSKKLARQNA EEIQSGKLIP TTNEEKTGLA LTGKNKNLKK
GEENEKTKFE AKHLGSSSAS DSLAESTLRS KKTKKGEVEK SELSIDMKNQ DKTTLATTLL
EDDLAKTTSA EESEAEHLVA LQNKEKTSLA MRRKRVSFDS STKSESIEDV IPDKNRDSDK
MSITGIKKKM SQKSESAEAQ KNESPEVKEI SSFEEKTLKS KKKSKADRNQ GTEANLGDKT
IDKDYLSVTD KNQSLEKSEA SGQAEKSIKA PNKSKVTTSF ADESLTSELD RLMADEEMAE
MMFAEEEKAA DLLNVMNKNK GLNKSEQEES QEISLKSQSK VKDSDSLSST DKKIGLKKSD
KDQKLGTSKI FGSKDQESVG YEEKTSNFSK QRRGVSDLGS DAMTDQKNVQ ESQYAEISAD
DHMSKTGADG EISATRTIVD GSDAAQGSEY AEISKKRKFK RAEQIGEAET SLCDSRENTH
DSLSISDVNP ELRRSNVEIS AFGQIDLTAE EVTSLTDINK DAQLTKKQDE NDAKKSVSKN
LKAGAKKDSD TLSITSKKDK FGKRQDSREA SATVEQQGEE KVTKNLKGSR GKKEKLGDAG
IDVNFENQEE FASTTGDIES IVSEKGHDTY SEKTVKSSKK KSPQTAGAEY GGSESLNASS
ALSTTDVDAQ LKNQEKDGVA ESSIGKSNQK DSYSEQELNV NKKKKQAVGA AMNQGSGSTK
ESDNLAVASV ESNLAKDSAN QEASLHGLVD NDATSLSQLD SEHRLKKRDD ELSAHTKLGK
HTQSENIALT ETDDSLVKGD SEESAELNIK QQGETAEDKY VESRKKTTLK KKPEQKQVTD
TLSAVDGRHD TTSLSVADSG ISFDKSMENE LAGSGDGTAS ASVSAKVRGA DGNAKTNLIS
SFEKPGQESK TSKTLSGKQK KQEKSSFAEK NAGFDLSMGE GKNDESVESS LQKNRDADSL
ALQGTDLAFS KPSDSSANAH LDMPQRELTL RICQAETVDW SDDSEVEEGT RTSAPGEVKK
KKKFIISAIS QDGEFSDAES ITFDENGVRV EKRRRKKRDP KEYMGAGELA MRIPAFAKKM
QYIGCIEGDV VVFTIKVVSD DVPLIRMYRN DFPVANFDKM AFEGFTKGSE HSFNVTINDI
RKLDGGKLVF EAKNDYGVDK CTILLDVRDS GSFIEDYSEI HRSAEIQNSV GDVQVKEGET
AKLTGRVDGF PLPELIWIKN GKEIDMMVPS TKYQLDYHSD GEFEARIANC TFEDDDDYSL
LVENLAGVDS CNFQVFVDCN EYPDDEHFNR RRRLQRGRRV MEASSDSELD DAKKRKKRRI
KRVVERRNPN APRLTQLIPP RFDKILSDHD AIEGENVVMM VETLGEPEPQ VRFYRDGKLI
DDGSGDRMEV RHEDEMRKHW LILKDICKDE EAEYACQAIN VAGEAWCFSD VVVHMSEESR
DDDKSVDEVD DSTVLEEKKD DGDDKSKPKT KKKIIKKKET PESEQVTAAE PEQQKISEVD
VQSVAETEVG AKKKPDAEKP TDLSKAKKDS KSKKSDEPEA STEEKSTTEK PTNDKTSKKS
AEKKTVKPKK EVTGKPLEAK KPVEDKKDAS QPSSSKESSP PTDGKKKKQI PKALFIPDEI
SSRFGDPSTM HSETNITTTI RGREGSADAK TPLVEPLSAS VSMKVESAKE KAEFSFKRRS
ETPDDKSRKK EGLPPAKKSE KKDEVTAEKQ STEALIESKK KEVDESKISE QQPSDKNKSE
VVGVPEKAAG PETKKDVSEI EEVPKKKTIK KKTEKSDSSI SQKSNVLKPA DDDKSKSDDV
TDKSKKTTED QTKVATDSKL EKAADTTKQI ETETVVDDKS KKKVLKKKTE KSDSFISQKS
ETPPVVEPTK PAESEAQKIA EVNKAKKQKE VDDNLKREAE VAAKKIADEK LKIEAEANIK
KTAEVEAAKK QKEKDEQLKL ETEVVSKKSA AEKLELEKQA QIKKAAEADA VKKQKELNEK
NKLEAAKKSA ADKLKLEEES AAKSKKVSEE SVKFGEEKKT KAGEKTVQVE SEPTSKKTID
TKDVGATEPA DETPKKKIIK KKTEKSDSSI SQKSATDSEK VSKQKEQDEP TKPAVSETQM
VTEADKSKKQ KETDEKLKLD AEIAAKTKQE ADEKSKLDAQ EKIKKVSEDD AARKEKELND
KLKLESEIAT KKASADKLKL EEQAQAKKAA EVEAAKKQKE KDEQLKLDTE AASKKAAAEK
LELEKQAQIK KAAGADAVKK QKELDEKNKL EANKKSAAGK LKIEEESAAK SKQTVEEQAK
LDAQTKAKTA EKQTKLEKDE KSTKESESKE TVDEKPKKKV LKKKTEKSDS SISQKSETSK
TVVESAGPSE SETQKVADAA RKQKETDEKQ KLEAEITAKK SADEKSKLEA ESKLKKAAEV
EAAKKQKEKD EQLKLDTEAA SKKAAAEKLE LEKQSHIKKA AEVDAVKKQK ELEEKQRLES
EAATKKADAE KLKLEEQKKK AAEIALIEIQ KEQEKLAQEQ SRLEDEAKKS AEKQKLESET
KSKQTEEAPK ESVDEKPKKK VLKKKTEKSD SSISQKSKSA KSTVDAAETL ESDFNLVEKK
TVQKVEQSPD ESTSATIKRD PAQKTEEISK QDDGDEKKTT TDGKPPKPED SEATPKKRVV
KKKTQKSDSV ASDASLADVS KLSDDVEEKP KKKVLKKKTE KSDSVISETS SVDTIKPESV
EIPTEKAEQM ILHNRFSTDS AVESEPKNAH KDDTEKTTDD MMTRRKSSAI FSDDEQSISS
KTSSEGRRRR RRTGFASKFA SDTLALRGDN VEIEAELLAE DDTVTWKVNG KDADLNSRCH
EMSHTFFRTL IIDEVEPTDS GMEITATCGT ESHTTILKVE ELPVDFVKYL PRKTSGKEGQ
EVTISVTLNH PIDISKVVWL KDGKPLEINK DYSIDTVGCS VSLTLRRAKY EDSGKYKVVC
DGVDCSTHLS IQGKPVLKNV SETKPVITVD KDDQFSLLVA YDSNPEASFS MTVDGKDLEF
DGRSRIDVVD DGLKLTKRGV SKTDAGEYEV KLKNEFGEVA QKFDVKVNDT PSAPGDVSVV
KAESDCLHIE WTAPTEDNGA EVTSYVIEKK ESGRRKFHKV ATVNGKKTSY VVDDLEIETP
YIVRIAAVNK FGTGEFIETK PVQTGSPFQV PTVEFPPTID NVTSTSCSLS WPKPIEDGGS
PVYGYDVYKR ENEGEWQKMN GEELVFTESF NVRALSSGKE YEFKIEACNE AGLRSNSNVV
SKKLTVEGLV PEIILDMPMV KVLDNDKVEV TWKSDGEKEF VVQYKSDGSS IWASVDIGGP
RSESAATSKC IIDGLREGIP YVFRVAARNQ HGTGEFSEPT IPVVVLADDA PRVLKAIKPV
KIPKKGELRL ECHAAGHPAP EYIWYKDGKE IIPTDENTEI VNEGSMSALI IHELAGEDVG
LYKVLVENIH GTAESEAEVG ISDVRAHFNS SFSELTEIEE GHDIELTCEV SDEEAVVNWY
KDGKKLVASD RVQFYAMARK RTLRIKGSTD ADSGVYKCET TDGRSRTEGE VIVNEQEPHI
LVGPQDAIVK DFGETMVLFC ETSKPVRKVK WFKNGVEIWP QMNKAIMEND GKRATLEIKN
FDKHDIGAYT ASVSEKETSA PAKLVFEVAP NLIIPTEIRD GVTVHAGNEF DFAVEFSGFP
IPTIHLTNNG TPLKAIAVVT EYDDSVSVRM KDVTLDNSGT VRVIAESPLG QCIKEIPLKI
IDKPSAPCDL QFKEVTEDSV FLSWQPPLET NGAPLTGYVI ERKAVDNNRW RPCGQVKPTK
LTFVAEDLFC NQVYGFRILA VNEVGESEPC DTVDVLTLES SEPVSESSEL FVPKIAILRT
PQVTVAVDET KVTLRWEECP ETSLYKVERK KVGDSDWLEI ANTDRNKFKD RSLTESGEYV
YQVTATGIHA VSSPSEETNP VKILVPGSEM PASKTEKKTD AAKSESEQKS AEEIVAEKQV
DQSQASESTT EAVEEKKTKK VVKKKVAENK GEETLQEVKE KLKKGKAVEK VQDESRRGSL
QASSDNESVT TTSEKRSEAE LEKNSEKSAE KKSTSADLEA ADKAETEKSE TGKETTEKKK
KVVKKVAKKG LVKADKSKIE LTAGKEGEIS AQVAETGVSV EWKKDGKALD ASYTVTSTGG
VSTVKIPIVD VNTSGVFTCK VKSSEGDEEE VSIAVTVKLP EVPKVEAEQS IVEVKVGDVA
KLSAKISEPA SSVNWTKDDK PIKEDGNVKA QLSPDGTAQL TISKTDSAHS GIYKLNVEND
AGKGKVEIAL RIKGAAKGAP GIPTGPIVFD DVTESSAEFS WKAPENNGGC EITGYNVERK
ESKNKGWKQC GKTKELKFKA DGLEEGTDYD VKVSAVNTMG TGSALEGKIT TLKKKEETGK
QKSEKSESDE KKSESDKVSE LKQIGKPEYV SSTATSIALK WTSDNDEVTY TVQMKEANSK
RPWAVVAKEI SECSATIAQL KEGTSYLFRV IAQNKTGQTV TSEQSESIEC KDTTESKKPA
FTNAPTDLTA VKNGKTKITA EFTGHPAPEI HWFKNKKEIF SGKRQWIENI AGATSLTIGE
MREDDEGEYK IVVKNTAGSV EHSCKLTMDQ LPEINRVDRY ASTLVFDKGE TVKLRLSFSG
RPQPEVIWID NNGKVIEESR KMKIEKTVLN TVLTINSIDS QDQGEFALKI KNRCGEDKYA
IGIQVTDRPA APGKPAVEDQ NVDSVRLRWA APTNDGGSPV RNYTVEMCTE KGKTWTKAEV
TKQAFITLFN LVPGESYRFR VRADNTFGQS EPSDESELVV VKNVSRVVEE PKKKEVKVKE
QESVDYERVA KDSEPSEYKT IDIHRLPNDL QAKYIIHEEL GKGAYGTVYR ATEKATGKTW
AAKMVQVRPG VKKENVIHEI SMMNQLHHEK LLNLHEAFDM GNEMWLIEEF VSGGELFEKI
LEDDSLMSEE EVRDYMHQIL LGVSHMHKNQ IVHLDLKPEN ILLKAKNSNE LKIIDFGLAR
KLDPKKSVKL LFGTPEFCAP EVVNYQPVGL STDMWTVGVI SYVLLSGLSP FLGDSDEDTL
ANVSASDWDF DDPSWDDVSD LAKDFICRLM IKDKRKRMSV QDALRHPWIT GPLLSAFNDL
SEYVKKMQPK LDKSGVPARQ KRNFLSLKRW SDDLLPIGRL AKRGAIFRRL TMDGVFERNI
AFDTDAAPSV KKQLEDIVAN VGDLIATLSC DVDGVPSPKV QWYKDDKELT VPSMKYDSFY
NEGLAELTVK NIVESDAGKY TCRATNDLGS IMTHAKLSVK ADEKKKKKSK TSPAVIEKKK
DRKTSKVVVI EEMIDMPPNF HHLLQDDEAK IGEPKILVVT NTTLPEPTVD WYHNGEHISI
NDSNYLRKHD KGRYELHILS VDSTDEGKWK AVGKNAFGEC ESEAKLTVVI PDGQYAPSFG
KQLSDVKCSE SDILKLEVNI QANPAPEINW FRNESEIEHS QHHRLQFDDG SGNYSLTIID
AYAEDSGEYK CVAKNKIGKA HTVCCVRIEE LLSKRSKKID GSKAPRFRMQ LPTPREVPQG
ADLTLVCSVS GTPHPNIKWT KDDKPIDMSN KQVRHENGVC TLHIIGARDD DQGRYVCEAE
NIHGVAQSFS VVEIKEAVDK DHVRPKFLEP LVNCSTCEGN EMVLECCVTG KPIPTITWYK
DGLKLIIENR MLQYTDRKGV SRLNIMNVVM NDDGEYTCEA VNSLGKDFTH CTVKVVDMGL
SKTRLTPVRS RSRSRSRSPS VVGGEIQRPP VVTRPLADAT VTEGNRELLE VEVDGFPTPT
IEWYHDGKLV AESRTLRTYF DGRVAFLKIY EAHEEHNGQY VCKVSNKLGA VETRAIVVVE
APDAAEHVTQ MPTFVKKLQD VVLKTAGETA TFTCQSYANP AAQVVWLHNG KALQQTKSNY
KTRLFDDNTA TLVIENVTDE LCGTYTAVAN NQFGDVHTSA QLTISGSEAK KIAASLPYFI
IELKPKINVV EGATLSIQAD LNGSPIPEVV WLKDNSELVE SDRIQMKCDG VNYQLLVRDV
GLEDEGTYTI TAENEKGKIR QNTEVSVTKS KEVKEKKEKK KVEKKDEGKK KPGRPGLPRP
SGASKTEQVT MAFDAPSEGP ADSYEVERRC PDQREWVSCG STKSLELEIK GLTPNTEYIF
RVAGKNKQGL GEWSEMTSTL KTASVGQAPQ FTISPQSKII ANRDDEFEIA VEFSGTPTPS
VKWYKENLQI VPDEKIDVAT TSTSSILNLK SQEENGTFNC LIENELGQAS ASCQVTIFNK
PASLQSTPDH SLERNLVPTL QKALNNESAQ AGQQIMLTCR ISSRSESTVA WFKDDERIES
AGRYELSSDK KSNHKLVCHA VQSQDTGKYR CVVTNKYGYA ESECNVAVED VTKFIAPSFS
ATLSDSTAIL GHNITLECKV EGSPAPEVSW TKDGERISTT RRIRQTQDEN GNCKLSISKA
ESDDMGVYVC SATSVAGVDS TSSMVMIAKT TGTDSHLVIA QTADEKHEKP RFTRAPPSLI
EVNESGQFTL IAKAVGEPKP TVTWLKDGRE ILRTNRIYHH FVTGDGESHL IAECVVSKTS
GIFSCKAENP NGTVIAETQV IVQRMKPANQ LANVAPKFTI PLTDMGIVNG HPTTLSCNVT
GSPEPTLEWI YIDDSGHKIN LTSSTTDWTE CRFGKVAELK SERVLREQRG TYQCIATNSS
GQATTQCYLL VGELSDEPAG PPRFVKCLQD TWTPLKESIE FSVELAGFPT PDLTWYHNEK
KINEGKDVKI TFPSDTTSVL SIKNVSLASL GMYFVEASNI HGVLRTAGRL NVSDERRKAE
PPQFKHVLEP VLAVQPKVAF SEEHPRASSS AATARVKKGA APMFLQGLED MDLKAGASAA
VAGKLGRKLR PHRSTTNDAD KLAKALAQSL RLDEPRASID SRPESAANAA LDEVRAAINS
RNKRVCRPKF MVKPKPRKVL EEYKSLRLKT AISGNPMPQV HWDKEGIILE TGNKYSIYND
GDFYYLEVHH VSTFDKGFYN CTAANNEGII TCTSEIDVLP NKEDSAAQVA KRKSRKEAKA
PNFIEVLPGR SQANLNESLC VECSVSAYPC ASIIWTRNSV RLLPQADRYT MSYDGECASL
KFISVTPGDE GTYACEAVNE LGSAVTNMNL QVSGVDPNAA EGIPPLFRFE KIKSVRKVVD
GSRVELAAEL VQASEPLQIR WLRNKVTIVD SPSFSYSRSE NMVFLTIADV FPEDGGEYTV
EAKNQSGIAR CTMQLDVRNN ERSVADEAPR VFDFEPTTRS DPGVSVELRA KVIGHPDPVI
SWTKAGQKLN NEEKYMMRNE GDKFILRIAN VTRADAGKYE LTAINPSGQA NAELELTVVQ
STKTVGAKPK FNESPISVQT CEKNRAELRA SFSGTPAPAC RWFYNGNELI DGLDGYTITS
SDTNSSLLIN SVDKKHFGEY LCTIRNQNGE ELANAMILSE VLSMFYSSLF LVVFVDIVAQ
CHVARLLHFL NEERFVGRNI FA
