TTPAL_HUMAN
ID TTPAL_HUMAN Reviewed; 342 AA.
AC Q9BTX7; E1P5X3; Q5QPC1; Q9H1G2; Q9NQG8;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Alpha-tocopherol transfer protein-like;
GN Name=TTPAL; Synonyms=C20orf121;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: May act as a protein that binds a hydrophobic ligand.
CC {ECO:0000305}.
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DR EMBL; AL132772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z97053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75918.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW75919.1; -; Genomic_DNA.
DR EMBL; BC003071; AAH03071.2; -; mRNA.
DR CCDS; CCDS13332.2; -.
DR RefSeq; NP_001034288.1; NM_001039199.2.
DR RefSeq; NP_077307.2; NM_024331.4.
DR RefSeq; XP_011527345.1; XM_011529043.2.
DR RefSeq; XP_011527346.1; XM_011529044.2.
DR AlphaFoldDB; Q9BTX7; -.
DR SMR; Q9BTX7; -.
DR BioGRID; 122598; 13.
DR IntAct; Q9BTX7; 1.
DR STRING; 9606.ENSP00000361995; -.
DR iPTMnet; Q9BTX7; -.
DR PhosphoSitePlus; Q9BTX7; -.
DR BioMuta; TTPAL; -.
DR DMDM; 76803550; -.
DR EPD; Q9BTX7; -.
DR jPOST; Q9BTX7; -.
DR MassIVE; Q9BTX7; -.
DR MaxQB; Q9BTX7; -.
DR PaxDb; Q9BTX7; -.
DR PeptideAtlas; Q9BTX7; -.
DR PRIDE; Q9BTX7; -.
DR ProteomicsDB; 79028; -.
DR Antibodypedia; 51852; 60 antibodies from 13 providers.
DR DNASU; 79183; -.
DR Ensembl; ENST00000262605.9; ENSP00000262605.4; ENSG00000124120.11.
DR Ensembl; ENST00000372904.7; ENSP00000361995.3; ENSG00000124120.11.
DR GeneID; 79183; -.
DR KEGG; hsa:79183; -.
DR MANE-Select; ENST00000262605.9; ENSP00000262605.4; NM_001039199.3; NP_001034288.1.
DR UCSC; uc002xmc.3; human.
DR CTD; 79183; -.
DR DisGeNET; 79183; -.
DR GeneCards; TTPAL; -.
DR HGNC; HGNC:16114; TTPAL.
DR HPA; ENSG00000124120; Tissue enhanced (liver).
DR neXtProt; NX_Q9BTX7; -.
DR OpenTargets; ENSG00000124120; -.
DR PharmGKB; PA162407296; -.
DR VEuPathDB; HostDB:ENSG00000124120; -.
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00940000155407; -.
DR InParanoid; Q9BTX7; -.
DR OMA; KEHPNLR; -.
DR OrthoDB; 1031056at2759; -.
DR PhylomeDB; Q9BTX7; -.
DR PathwayCommons; Q9BTX7; -.
DR SignaLink; Q9BTX7; -.
DR BioGRID-ORCS; 79183; 11 hits in 1079 CRISPR screens.
DR ChiTaRS; TTPAL; human.
DR GenomeRNAi; 79183; -.
DR Pharos; Q9BTX7; Tdark.
DR PRO; PR:Q9BTX7; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BTX7; protein.
DR Bgee; ENSG00000124120; Expressed in decidua and 177 other tissues.
DR ExpressionAtlas; Q9BTX7; baseline and differential.
DR Genevisible; Q9BTX7; HS.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IBA:GO_Central.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF03765; CRAL_TRIO_N; 1.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Transport.
FT CHAIN 1..342
FT /note="Alpha-tocopherol transfer protein-like"
FT /id="PRO_0000210772"
FT DOMAIN 117..282
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 278
FT /note="A -> G (in dbSNP:rs59069332)"
FT /id="VAR_061788"
SQ SEQUENCE 342 AA; 38515 MW; 56EDFC06C6D85CFB CRC64;
MSEESDSLRT SPSVASLSEN ELPPPPEPPG YVCSLTEDLV TKAREELQEK PEWRLRDVQA
LRDMVRKEYP NLSTSLDDAF LLRFLRARKF DYDRALQLLV NYHSCRRSWP EVFNNLKPSA
LKDVLASGFL TVLPHTDPRG CHVVCIRPDR WIPSNYPITE NIRAIYLTLE KLIQSEETQV
NGIVILADYK GVSLSKASHF GPFIAKKVIG ILQDGFPIRI KAVHVVNEPR IFKGIFAIIK
PFLKEKIANR FFLHGSDLNS LHTNLPRSIL PKEYGGTAGE LDTATWNAVL LASEDDFVKE
FCQPVPACDS ILGQTLLPEG LTSDAQCDDS LRAVKSQLYS CY
