TTPAL_MOUSE
ID TTPAL_MOUSE Reviewed; 343 AA.
AC Q9D3D0; A6PW51; Q3U0R3; Q7TS94;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Alpha-tocopherol transfer protein-like;
GN Name=Ttpal;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Brain cortex, Cecum, Embryonic head, Spinal cord, Spleen, and
RC Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryonic brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May act as a protein that binds a hydrophobic ligand.
CC {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D3D0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D3D0-2; Sequence=VSP_006032, VSP_006033;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC28381.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC30352.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC31654.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC38289.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK018052; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK033600; BAC28381.1; ALT_INIT; mRNA.
DR EMBL; AK039450; BAC30352.1; ALT_INIT; mRNA.
DR EMBL; AK043791; BAC31654.1; ALT_INIT; mRNA.
DR EMBL; AK081680; BAC38289.1; ALT_INIT; mRNA.
DR EMBL; AK156641; BAE33788.1; -; mRNA.
DR EMBL; AL591488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052389; AAH52389.3; -; mRNA.
DR CCDS; CCDS38317.1; -. [Q9D3D0-1]
DR RefSeq; NP_001292732.1; NM_001305803.1.
DR RefSeq; NP_083788.2; NM_029512.2. [Q9D3D0-1]
DR RefSeq; NP_859423.2; NM_181734.3. [Q9D3D0-1]
DR RefSeq; XP_006500424.1; XM_006500361.1. [Q9D3D0-1]
DR RefSeq; XP_006500425.1; XM_006500362.1. [Q9D3D0-1]
DR AlphaFoldDB; Q9D3D0; -.
DR SMR; Q9D3D0; -.
DR BioGRID; 217950; 1.
DR STRING; 10090.ENSMUSP00000128922; -.
DR iPTMnet; Q9D3D0; -.
DR PhosphoSitePlus; Q9D3D0; -.
DR SwissPalm; Q9D3D0; -.
DR EPD; Q9D3D0; -.
DR MaxQB; Q9D3D0; -.
DR PaxDb; Q9D3D0; -.
DR PeptideAtlas; Q9D3D0; -.
DR PRIDE; Q9D3D0; -.
DR ProteomicsDB; 298023; -. [Q9D3D0-1]
DR ProteomicsDB; 298024; -. [Q9D3D0-2]
DR Antibodypedia; 51852; 60 antibodies from 13 providers.
DR DNASU; 76080; -.
DR Ensembl; ENSMUST00000109405; ENSMUSP00000105032; ENSMUSG00000017679. [Q9D3D0-2]
DR Ensembl; ENSMUST00000109408; ENSMUSP00000105035; ENSMUSG00000017679. [Q9D3D0-1]
DR Ensembl; ENSMUST00000171696; ENSMUSP00000128922; ENSMUSG00000017679. [Q9D3D0-1]
DR GeneID; 76080; -.
DR KEGG; mmu:76080; -.
DR UCSC; uc008ntc.1; mouse. [Q9D3D0-1]
DR UCSC; uc008ntf.1; mouse. [Q9D3D0-2]
DR CTD; 79183; -.
DR MGI; MGI:1923330; Ttpal.
DR VEuPathDB; HostDB:ENSMUSG00000017679; -.
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00940000155407; -.
DR HOGENOM; CLU_046597_1_3_1; -.
DR InParanoid; Q9D3D0; -.
DR OMA; KEHPNLR; -.
DR OrthoDB; 1031056at2759; -.
DR PhylomeDB; Q9D3D0; -.
DR BioGRID-ORCS; 76080; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Ttpal; mouse.
DR PRO; PR:Q9D3D0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D3D0; protein.
DR Bgee; ENSMUSG00000017679; Expressed in esophagus and 220 other tissues.
DR ExpressionAtlas; Q9D3D0; baseline and differential.
DR Genevisible; Q9D3D0; MM.
DR GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IBA:GO_Central.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF03765; CRAL_TRIO_N; 1.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Transport.
FT CHAIN 1..343
FT /note="Alpha-tocopherol transfer protein-like"
FT /id="PRO_0000210773"
FT DOMAIN 118..283
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 150..168
FT /note="DRWIPSNYPITENIRAVYL -> GWLPHSDKSSSHSERTSDI (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_006032"
FT VAR_SEQ 169..343
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_006033"
SQ SEQUENCE 343 AA; 38836 MW; 67D38F0799FD81B2 CRC64;
MSEESDSLRT SPSVASLSEN ELPLPPPDPP GYVCSLTEDL VTKAREELQE KPEWRLRDVQ
ALRDMVRKEY PYLSTSLDDA FLLRFLRARK FDYDRALQLL VNYHGCRRSW PEVFSNLRPS
ALKDVLNSGF LTVLPHTDPR GCHVLCIRPD RWIPSNYPIT ENIRAVYLTL EKLIQSEETQ
VNGIVILADY KGVSLSKASH FGPFIAKKVI GILQDGFPIR IKAVHIVNEP RIFKGIFAII
KPFLKEKIAN RFFLHGSDLN SLHTNLPRNI LPKEYGGTAG ELDTASWNAV LLASEEDFVK
EFCQPMPACD NLLGQPLLPE GLISDAQCDD SMRAMKSQLY SCY
