TTR33_CAEEL
ID TTR33_CAEEL Reviewed; 143 AA.
AC Q8I7H9;
DT 22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Transthyretin-like protein 33 {ECO:0000312|WormBase:C37C3.13};
DE Flags: Precursor;
GN Name=ttr-33 {ECO:0000303|PubMed:29346382, ECO:0000312|WormBase:C37C3.13};
GN ORFNames=C37C3.13 {ECO:0000312|WormBase:C37C3.13};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND MUTAGENESIS OF GLY-27 AND LEU-72.
RX PubMed=29346382; DOI=10.1371/journal.pgen.1007125;
RA Offenburger S.L., Ho X.Y., Tachie-Menson T., Coakley S., Hilliard M.A.,
RA Gartner A.;
RT "6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is
RT promoted by the engulfment pathway and inhibited by the transthyretin-
RT related protein TTR-33.";
RL PLoS Genet. 14:E1007125-E1007125(2018).
CC -!- FUNCTION: Protects dopaminergic neurons from degeneration caused by
CC oxidative stress. {ECO:0000269|PubMed:29346382}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29346382}.
CC -!- TISSUE SPECIFICITY: Expressed in head cells next to and anterior of the
CC first pharyngeal bulb, the pharynx, and the hypodermis.
CC {ECO:0000269|PubMed:29346382}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development
CC (PubMed:29346382). First expressed in the embryonic pretzel stage
CC (PubMed:29346382). In L1 stage larvae, expressed next to the pharyngeal
CC bulb, between the mouth and first pharyngeal bulb, in the pharynx and
CC in cells posterior to the second pharyngeal bulb (PubMed:29346382).
CC {ECO:0000269|PubMed:29346382}.
CC -!- SIMILARITY: Belongs to the nematode transthyretin-like family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284605; CCD66955.1; -; Genomic_DNA.
DR RefSeq; NP_872192.1; NM_182392.6.
DR AlphaFoldDB; Q8I7H9; -.
DR SMR; Q8I7H9; -.
DR STRING; 6239.C37C3.13.2; -.
DR EPD; Q8I7H9; -.
DR PaxDb; Q8I7H9; -.
DR PeptideAtlas; Q8I7H9; -.
DR EnsemblMetazoa; C37C3.13.1; C37C3.13.1; WBGene00016505.
DR GeneID; 259631; -.
DR KEGG; cel:CELE_C37C3.13; -.
DR UCSC; C37C3.13.1; c. elegans.
DR CTD; 259631; -.
DR WormBase; C37C3.13; CE32820; WBGene00016505; ttr-33.
DR eggNOG; ENOG502S1IK; Eukaryota.
DR HOGENOM; CLU_121109_4_1_1; -.
DR InParanoid; Q8I7H9; -.
DR OMA; MQIEFES; -.
DR OrthoDB; 1464564at2759; -.
DR PhylomeDB; Q8I7H9; -.
DR PRO; PR:Q8I7H9; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00016505; Expressed in larva and 3 other tissues.
DR GO; GO:0009986; C:cell surface; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.3330; -; 1.
DR InterPro; IPR001534; Transthyretin-like.
DR InterPro; IPR038479; Transthyretin-like_sf.
DR PANTHER; PTHR21700; PTHR21700; 1.
DR Pfam; PF01060; TTR-52; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..143
FT /note="Transthyretin-like protein 33"
FT /evidence="ECO:0000255"
FT /id="PRO_5004308455"
FT MUTAGEN 27
FT /note="G->E: In gt1983; increased sensitivity to the
FT neurotoxin 6-hydroxydopamine (6-OHDA) during the first
FT three larval stages resulting in the degeneration of
FT dopaminergic head neurons. Reduced survival and
FT developmental defects in response to oxidative stress-
FT induced by paraquat. No defects in the rate of axonal
FT regrowth, reconnection or fusion after injury. No
FT degeneration of dopaminergic head neurons in a dat-1
FT (ok157) mutant background in response to 6-OHDA.
FT Dopaminergic neurodegeneration is partially suppressed in a
FT ced-6 (n1813) or ced-10 (n3246) mutant background in
FT response to 6-OHDA."
FT /evidence="ECO:0000269|PubMed:29346382"
FT MUTAGEN 72
FT /note="L->F: In gk567379; increased sensitivity to the
FT neurotoxin 6-hydroxydopamine (6-OHDA) during the first
FT three larval stages resulting in the degeneration of
FT dopaminergic head neurons."
FT /evidence="ECO:0000269|PubMed:29346382"
SQ SEQUENCE 143 AA; 15684 MW; C49D4DF6FC818124 CRC64;
MSRLACISSL FILCAIGSEA VFTQSAGVKG VLMCGDKPLA NTKVKLYDDD TGPDLDDLLA
EGTTDSLGQF LLTGHTSEVM TIDPKLNIYH DCDDGLKPCQ RRVTFNIPKS FVSSGENPKT
FFNIGTINMQ IEFESESRDC LHR
