TTRR_SALTY
ID TTRR_SALTY Reviewed; 206 AA.
AC Q7CQM8; Q7B2G4; Q7BK20;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Tetrathionate response regulatory protein TtrR;
GN Name=ttrR; OrderedLocusNames=STM1387;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=10027966; DOI=10.1046/j.1365-2958.1999.01190.x;
RA Hensel M., Egelseer C., Nikolaus T.;
RT "Molecular and functional analysis indicates a mosaic structure of
RT Salmonella pathogenicity island 2.";
RL Mol. Microbiol. 31:489-498(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=LT2;
RX PubMed=11274105; DOI=10.1128/jb.183.8.2463-2475.2001;
RA Price-Carter M., Tingey J., Bobik T.A., Roth J.R.;
RT "The alternative electron acceptor tetrathionate supports B12-dependent
RT anaerobic growth of Salmonella enterica serovar typhimurium on ethanolamine
RT or 1,2-propanediol.";
RL J. Bacteriol. 183:2463-2475(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [4]
RP FUNCTION.
RC STRAIN=LT2;
RX PubMed=10231485; DOI=10.1046/j.1365-2958.1999.01345.x;
RA Hensel M., Hinsley A.P., Nikolaus T., Sawers G., Berks B.C.;
RT "The genetic basis of tetrathionate respiration in Salmonella
RT typhimurium.";
RL Mol. Microbiol. 32:275-287(1999).
RN [5]
RP FUNCTION IN VIRULENCE.
RX PubMed=20864996; DOI=10.1038/nature09415;
RA Winter S.E., Thiennimitr P., Winter M.G., Butler B.P., Huseby D.L.,
RA Crawford R.W., Russell J.M., Bevins C.L., Adams L.G., Tsolis R.M.,
RA Roth J.R., Baumler A.J.;
RT "Gut inflammation provides a respiratory electron acceptor for
RT Salmonella.";
RL Nature 467:426-429(2010).
CC -!- FUNCTION: Member of the two-component regulatory system TtrR/TtrS,
CC which is required for synthesis of tetrathionate reductase. Positively
CC regulates transcription of the ttrBCA operon. During mice infection,
CC the ability to use tetrathionate as an electron acceptor is a growth
CC advantage for S.typhimurium over the competing microbiota in the lumen
CC of the inflamed gut. {ECO:0000269|PubMed:10231485,
CC ECO:0000269|PubMed:11274105, ECO:0000269|PubMed:20864996}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by TtrS. {ECO:0000250}.
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DR EMBL; AJ224978; CAB37412.1; -; Genomic_DNA.
DR EMBL; AF282268; AAG31755.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20311.1; -; Genomic_DNA.
DR RefSeq; NP_460352.3; NC_003197.2.
DR RefSeq; WP_000190927.1; NC_003197.2.
DR AlphaFoldDB; Q7CQM8; -.
DR SMR; Q7CQM8; -.
DR STRING; 99287.STM1387; -.
DR PaxDb; Q7CQM8; -.
DR EnsemblBacteria; AAL20311; AAL20311; STM1387.
DR GeneID; 1252905; -.
DR KEGG; stm:STM1387; -.
DR HOGENOM; CLU_000445_90_4_6; -.
DR OMA; DACEGGR; -.
DR PhylomeDB; Q7CQM8; -.
DR BioCyc; SENT99287:STM1387-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..206
FT /note="Tetrathionate response regulatory protein TtrR"
FT /id="PRO_0000417423"
FT DOMAIN 3..117
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 134..194
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT DNA_BIND 153..172
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT MOD_RES 52
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 206 AA; 22692 MW; 0A939DCE51CDE8E6 CRC64;
MATIHLLDDD TAVTNACAFL LESLGYDVKC WTQGADFLAQ ASLYQAGVVL LDMRMPVLDG
QGVHDALRQC GSTLAVVFLT GHGDVPMAVE QMKRGAVDFL QKPVSVKPLQ AALERALTVS
SAAVARREII LCYQQLTPKE RELASLVAKG FMNREIAEAM NIAVRTVEVH RARVMEKMQA
GSLAELIRRF EKMASPETRI RTTYEP
