ID   TTR_PSEAJ               Reviewed;         177 AA.
AC   P16966;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Acetyltransferase;
DE            EC=2.3.1.-;
DE   AltName: Full=Tabtoxin resistance protein;
GN   Name=ttr;
OS   Pseudomonas amygdali pv. tabaci (Pseudomonas syringae pv. tabaci).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas amygdali.
OX   NCBI_TaxID=322;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MAFF03-01075;
RX   PubMed=2336364; DOI=10.1093/nar/18.7.1890;
RA   Anzai H., Yoneyama K., Yamaguchi I.;
RT   "The nucleotide sequence of tabtoxin resistance gene (ttr) of Pseudomonas
RT   syringae pv. tabaci.";
RL   Nucleic Acids Res. 18:1890-1890(1990).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) IN COMPLEX WITH ACETYL-COA, AND
RP   FUNCTION.
RX   PubMed=12527305; DOI=10.1016/s0022-2836(02)01284-6;
RA   He H., Ding Y., Bartlam M., Sun F., Le Y., Qin X., Tang H., Zhang R.,
RA   Joachimiak A., Liu J., Zhao N., Rao Z.;
RT   "Crystal structure of tabtoxin resistance protein complexed with acetyl
RT   coenzyme A reveals the mechanism for beta-lactam acetylation.";
RL   J. Mol. Biol. 325:1019-1030(2003).
CC   -!- FUNCTION: Renders tabtoxin-producing pathogens tolerant to their own
CC       phytotoxins. {ECO:0000269|PubMed:12527305}.
CC   -!- MISCELLANEOUS: Tabtoxin causes wildfire disease of tobacco.
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DR   EMBL; X17150; CAA35037.1; -; Genomic_DNA.
DR   PIR; S09214; S09214.
DR   RefSeq; WP_002555402.1; NZ_RBSE01000043.1.
DR   PDB; 1GHE; X-ray; 1.55 A; A/B=1-177.
DR   PDB; 1J4J; X-ray; 2.55 A; A/B=1-177.
DR   PDBsum; 1GHE; -.
DR   PDBsum; 1J4J; -.
DR   AlphaFoldDB; P16966; -.
DR   SMR; P16966; -.
DR   GeneID; 61872015; -.
DR   KEGG; ag:CAA35037; -.
DR   BioCyc; MetaCyc:MON-20391; -.
DR   EvolutionaryTrace; P16966; -.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   Pfam; PF13673; Acetyltransf_10; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acyltransferase; Transferase.
FT   CHAIN           1..177
FT                   /note="Acetyltransferase"
FT                   /id="PRO_0000065680"
FT   DOMAIN          4..174
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
FT   BINDING         27
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /evidence="ECO:0000269|PubMed:12527305"
FT   BINDING         96..98
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   BINDING         104..109
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   BINDING         130..131
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   BINDING         141
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /evidence="ECO:0000269|PubMed:12527305"
FT   STRAND          5..8
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   TURN            11..13
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   HELIX           14..30
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   HELIX           43..51
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   HELIX           54..59
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   STRAND          60..69
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   STRAND          72..81
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   STRAND          90..98
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   HELIX           100..102
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   HELIX           107..121
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   STRAND          126..132
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   HELIX           136..143
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   STRAND          147..157
FT                   /evidence="ECO:0007829|PDB:1GHE"
FT   STRAND          163..172
FT                   /evidence="ECO:0007829|PDB:1GHE"
SQ   SEQUENCE   177 AA;  19235 MW;  8D278EC9AB27E9DF CRC64;
     MNHAQLRRVT AESFAHYRHG LAQLLFETVH GGASVGFMAD LDMQQAYAWC DGLKADIAAG
     SLLLWVVAED DNVLASAQLS LCQKPNGLNR AEVQKLMVLP SARGRGLGRQ LMDEVEQVAV
     KHKRGLLHLD TEAGSVAEAF YSALAYTRVG ELPGYCATPD GRLHPTAIYF KTLGQPT